Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurological condition. The rising prevalence of AD necessitates the rapid development of efficient therapy options. Despite substantial study, only a few medications are capable of delaying the disease. Several substances with pharmacological activity, derived from plants, have been shown to have positive benefits for the treatment of AD by targeting various enzymes, such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), β-secretase, γ-secretase, and monoamine oxidases (MAOs), which are discussed as potential targets. Medicinal plants have already contributed a number of lead molecules to medicine development, with many of them currently undergoing clinical trials. A variety of medicinal plants have been shown to diminish the degenerative symptoms associated with AD, either in their raw form or as isolated compounds. The aim of this review was to provide a brief summary of AD and its current therapies, followed by a discussion of the natural compounds examined as therapeutic agents and the processes underlying the positive effects, particularly the management of AD.     

Investigation Driven by Network Pharmacology on Potential Components and Mechanism of DGS,a Natural Vasoprotective Combination,for the Phytotherapy of Coronary Artery Disease

Phytotherapy offers obvious advantages in the intervention of Coronary Artery Disease (CAD), but it is difficult to clarify the working mechanisms of the medicinal materials it uses. DGS is a natural vasoprotective combination that was screened out in our previous research, yet its potential components and mechanisms are unknown. Therefore, in this study, HPLC-MS and network pharmacology were employed to identify the active components and key signaling pathways of DGS. Transgenic zebrafish and HUVECs cell assays were used to evaluate the effectiveness of DGS. A total of 37 potentially active compounds were identified that interacted with 112 potential targets of CAD. Furthermore, PI3K-Akt, MAPK, relaxin, VEGF, and other signal pathways were determined to be the most promising DGS-mediated pathways. NO kit, ELISA, and Western blot results showed that DGS significantly promoted NO and VEGFA secretion via the upregulation of VEGFR2 expression and the phosphorylation of Akt, Erk1/2, and eNOS to cause angiogenesis and vasodilation. The result of dynamics molecular docking indicated that Salvianolic acid C may be a key active component of DGS in the treatment of CAD. In conclusion, this study has shed light on the network molecular mechanism of DGS for the intervention of CAD using a network pharmacology-driven strategy for the first time to aid in the intervention of CAD.     

6σ管理和统计技术

从6σ名称,绿带、黑带的评定标准和培训内容都体现了统计技术是6σ管理的核心技术。DMAIC统计技术应用模式虽有不足,最大功绩是使应用统计技术简单化,实际应用者认识了统计技术的重要性。     

云桌面技术在高职院校的运用与推广分析

基于计算机信息技术的高速发展,高校实验室对协同作业与资源自适应调配等个性化需求日益增加.针对传统计算机实验室在建设与维护过程中的存在一些弊端,如:前期投入成本高、设备整体利用率低、管理效率低、数据安全性与网络传输效率较差等客观问题,文章将对现有教学资源及需求进行分析,结合云桌面技术优势,论证云桌面技术可行性研究,推动实...     

改进的MEA-WNN图像复原方法

模糊图像复原是计算机视觉和图像处理领域的重要任务。针对思维进化算法(mind evolutionary algorithm,MEA)和小波神经网络(wavelet neural network,WNN)相结合的图像复原模型中,MEA的得分函数相对差别小、选优功能较弱等问题,提出了一种改进的MEA-WNN图像复原方法。该方法采用逻辑回归函数进行幂律变换,增加得分之间的差别,从而增强MEA的选优功能。将改进的模型与传统的基于WNN和MEA-WNN的图像复原模型进行对比,改进的模型把复原图像峰值信噪比(peak signal-to-noise ratio,PSNR)分别提高15%和6.5%、结构相似性(structural similarity,SSIM)提高了6.1%和5%,实验结果证明改进模型的有效性和优越性。     

电信网络风险评估指标体系研究及应用

为评估电信网的风险,可通过分析风险与安全事件的关系,以安全事件的组成元素构建电信网的风险评估指标体系,并进行风险的分级量化.本文分析了电信网的风险模糊综合评估方法,并进行了实例计算.该方法可作为电信网风险评估的一种有效方法.     

测量平衡器件混合模S参数的数学巴伦法

由于传统网络分析仪各测量端口都是单端的,无法通过直接测量得到平衡器件混合模散射参数(S参数).数学巴伦法是一种数学上的处理方法,在实际测量时将每个差分端口的两端分别与地看作一个单端(非平衡)端口,用普通网络分析仪测量出多端口非平衡S参数,再经过数学处理得到平衡器件的混合模S参数,而不需外加物理巴伦.文章给出了数学巴伦法的基本理论,推导了混合模S参数与实测非平衡多端口S参数之间的关系,以一个双定向耦合器作为例验证了理论的正确性,所得混合模S参数处理结果与直接测量结果吻合很好.     

基于NTP协议的网络时间服务系统的实现

本文介绍了网络时间协议的基本工作原理,简要分析了在网络路径对称和不对称两种情况下的网络时延问题.论述了网络时间服务器的构建方法和网络授时软件的设计流程.应用数据统计,对网络时延和时差作了详细分析,给出了在软件设计中处理与网络时延和时差相关问题的方法.最后阐明了建立网络时间服务体系的必要性.     

基于单片机的网络电表数据集中器的开发

本文旨在开发一种基于单片机的新型智能网络电表数据集中器,实现HFC智能网络电表系统项目的技术要求。本文提出了硬件设计方案并给出了单片机和网络处理器的选型。在软件系统中采用Keil C51的集成开发工具设计了数据集中器软件。该软件主要由三大功能模块构成,分别为数据集中器模块,串行数据通讯模块,网络通讯模块。根据项目的总体要求,遵循上位机与电表数据集中器的协议规范,以及数据集中器和下位机电表的协议规范进行设计。通过调试表明了该数据集中器可靠的运行。     

光传输网规划中光缆芯数及光纤类型确定的影响因素

光传输网是电信网的基础,由于光缆线路系统的特殊性,决定了光传输网规划中光缆芯数及光纤类型的确定尤其重要。