Efficient monooleoyl glycerol synthesis employing hybrid ultrasonic-infrared-wave promoted reactor: Concurrent catalytic and noncatalytic esterification kinetics

For the first time, intensification of monooleoyl glycerol (MOG) synthesis has been investigated in an ultrasonic-infrared-wave (USIRW) promoted batch reactor. Esterification of octadecanoic acid (ODA) with glycerol (Gl) has been conducted [using Amberlyst 36 wet catalyst] in three different reactors, namely traditional batch reactor (TBR), infrared wave promoted batch reactor (IRWPBR), and USIRW-promoted batch reactor (USIRWPBR) to assess the relative efficacy. The energy-efficient USIRWPBR remarkably intensifies the ODA-Gl esterification as manifested through superior ODA conversion (92.5 ± 1.25%) compared to that achieved in IRWPBR (79.8 ± 1.2%) and TBR (36.39 ± 1.25%). The most favorable reaction condition for optimum ODA conversion and maximum MOG yield was identified through statistical optimization over a selected parametric range, namely 3-5 Gl/ODA mole ratio, 0.004-0.006 g/mL Amberlyst 36 catalyst concentration, 300-700 rpm impeller speed, and 333-353 K reaction temperature. The present study also reports the formulation and validation of an innovative reaction kinetics, that is, concurrent noncatalytic and heterogeneously catalyzed (CNCHC) reaction mechanism in addition to the conventional heterogeneous kinetic models (LH and Eley-Rideal mechanisms). Under combined USIRW, the CNCHC esterification mechanism could best describe ODA-Gl esterification (R² = 0.98) compared to LH (R² = 0.97) and Eley-Rideal (R² = 0.88) mechanisms. The optimal product (MOG) was characterized by differential scanning calorimetry and thermogravimetric analysis to assess its crystallization property and thermal stability for possible application as plasticizer/fuel additives.     

一种高效群签名方案的设计与分析

基于ElGamal密码体制及其签名算法,构造了一个高效安全的群签名方案。在签名初始化阶段,把群管理者分成两个部分T1和T2, T1负责签名群成员的加入,删除和密钥发行。如果发生争端需要仲裁,那么可由T2负责打开群签名并进行追踪,这种方法有效地实现了签名群中成员的动态管理,具有一定的高效性、安全性和实用性。方案给出了详细的设计过程,并对其高效性和安全性进行了分析,为群签名方案的设计与实现提供了一种参考。     

高效的无证书广义指定验证者聚合签名方案

研究无证书广义指定验证者聚合签名的安全模型,基于双线性映射提出无证书广义指定验证者聚合签名方案。在随机预言模型和计算Diffie-Hellman困难问题假设下,证明方案不仅可以抵抗无证书广义指定验证者聚合签名的3类伪造攻击,而且满足指定验证性和不可传递性。方案的聚合签名长度和单用户签名长度相当,签名公共验证和指定验证需要的双线性对数固定。     

LabWindows/CVI多线程技术的应用

LabWindows/CVI多线程技术可保证并发任务的顺利执行。多线程技术解决了并发任务之间的冲突问题,能大幅提高工作效率。针对多个线程之间数据共享与传递,提供了良好的数据保护机制。文中对数据保护的机制与具体实现方法进行了阐述,结合多线程技术完成了仪器自动控制界面开发,试验证明,多线程技术的优势在并发任务系统中得到良好的体现。     

基于SIM卡的金融应用移动数字签名业务研究

随着智能终端和移动互联网的快速发展,在网上银行等行业应用中使用移动终端进行用户认证的方式愈发普及.传统的USB key用户认证方式逐渐被基于移动终端的用户认证方式取代.从移动运营商角度出发,研究分析了利用移动终端和SIM卡实现金融类应用用户数字签名认证的技术要求,梳理了基于智能终端和智能卡的安全技术,提出了基于电信智能卡的金融类应用用户签名和身份认证的技术架构和业务流程.     

In Vitro Effects of Sulforaphane on Interferon-Driven Inflammation and Exploratory Evaluation in Two Healthy Volunteers

Interferonopathies are rare genetic conditions defined by systemic inflammatory episodes caused by innate immune system activation in the absence of pathogens. Currently, no targeted drugs are authorized for clinical use in these diseases. In this work, we studied the contribution of sulforaphane (SFN), a cruciferous-derived bioactive molecule, in the modulation of interferon-driven inflammation in an immortalized human hepatocytes (IHH) line and in two healthy volunteers, focusing on STING, a key-component player in interferon pathway, interferon signature modulation, and GSTM1 expression and genotype, which contributes to SFN metabolism and excretion. In vitro, SFN exposure reduced STING expression as well as interferon signature in the presence of the pro-inflammatory stimulus cGAMP (cGAMP 3 h vs. SFN+cGAMP 3 h p value < 0.0001; cGAMP 6 h vs. SFN+cGAMP 6 h p < 0.001, one way ANOVA), restoring STING expression to the level of unstimulated cells. In preliminary experiments on healthy volunteers, no appreciable variations in interferon signature were identified after SFN assumption, while only in one of them, presenting the GSTM1 wild type genotype related to reduced SFN excretion, could a downregulation of STING be recorded. This study confirmed that SFN inhibits STING-mediated inflammation and interferon-stimulated genes expression in vitro. However, only a trend towards the downregulation of STING could be reproduced in vivo. Results obtained have to be confirmed in a larger group of healthy individuals and in patients with type I interferonopathies to define if the assumption of SFN could be useful as supportive therapy.     

两种环签名方案的安全性分析及其改进

通过对Xu(2004)和Zhang(2004)提出的两种环签名方案进行分析,指出了这两种环签名方案都容易受到群成员改变攻击(group-changing attack),并给出了攻击方法;另外,Zhang的方案还容易受到多已知签名存在伪造(multiple-known-signature existential forgery)攻击。为防范这两种攻击,对这两种环签名方案进行了改进,改进后的方案在最强的安全模型(Joseph, 2004提出)中仍是安全的。     

Improvement of nonrepudiable threshold multi-proxy threshold multi-signature scheme with shared verification

In 2005, Bao, et al. [Appl. Math. and Comput., vol.169, No.2, 2005] showed that Tzeng, et al.’s nonrepudiable threshold multi-proxy multi-signature scheme with shared verification was insecure, and proposed an improved scheme with no Share Distribution Center (SDC). This paper shows that Bao, et al.’s scheme suffers from the proxy relationship inversion attack and forgery attack, and pro- poses an improvement of Bao, et al.’s scheme.     

对一种群签名方案的伪造攻击

王晓明等人提出一种群签名方案(2003),并称可以抵抗各种伪造攻击,而且可以进行群成员的注销,但是经过认真分析,该方案存在安全隐患:首先,无法进行有效注销群成员。其次,攻击者可以伪造签名通过验证而使群权威无法识别。本文提出一种有效的攻击方案,并给出安全群签名方案的应具备的两个要素。     

Development of a Genus-Universal Nucleotide Signature for the Identification and Supervision of Ephedra-Containing Products

Ephedra plants generally contain ephedrine alkaloids, which are the critical precursor compounds of methamphetamine (METH). METH could cause serious physical and mental damage, and therefore Ephedra materials are strictly in supervision internationally. However, unlawful utilization of Ephedra herbs and its products still exist. Thus, it is imperative to establish a universal method for monitoring Ephedra ingredients in complex mixtures and processed products. In this study, 224 ITS2 sequences representing 59 taxa within Ephedra were collected, and a 23-bp genus-level nucleotide signature (GTCCGGTCCGCCTCGGCGGTGCG) was developed for the identification of the whole genus. The specific primers MH-1F/1R were designed, and 125 individuals of twelve Ephedra species/varieties were gathered for applicability verification of the nucleotide signature. Additionally, seven batches of Chinese patent medicines containing Ephedra herbs were used to test the application of the nucleotide signature in complex and highly processed materials. The results demonstrated that the 23-bp molecular marker was unique to Ephedra and conserved within the genus. It can be successfully utilized for the detection of Ephedra components in complex preparations and processed products with severe DNA degradation. The method developed in this study could undoubtedly serve as a strong support for the supervision of illegal circulation of Ephedra-containing products.