Direct high-performance liquid chromatography enantioseparation of terazosin on an immobilised polysaccharide-based chiral stationary phase under polar organic and reversed-phase conditions

High-performance liquid chromatography (HPLC) enantioseparation of terazosin (TER) was accomplished on the immobilised-type Chiralpak IC chiral stationary phase (CSP) under both polar organic and reversed-phase modes. A simple analytical method was validated using a mixture of methanol–water–DEA 95:5:0.1 (v/v/v) as a mobile phase. Under reversed-phase conditions good linearities were obtained over the concentration range 8.76–26.28 μg mL⁻¹ for both enantiomers. The limits of detection and quantification were 10 and 30 ng mL⁻¹, respectively. The intra- and inter-day assay precision was less than 1.66% (RSD%). The optimised conditions also allowed to resolve chiral and achiral impurities from the enantiomers of TER. The proposed HPLC method supports pharmacological studies on the biological effects of the both forms of TER and analytical investigations of potential drug formulations based on a single enantiomer. At the semipreparative scale, 5.3 mg of racemic sample were resolved with elution times less than 12 min using a mobile phase consisting of methanol–DEA 100:0.1 (v/v) and both enantiomers were isolated with a purity of ≥99% enantiomeric excess (ee). The absolute configuration of TER enantiomers was assigned by comparison of the measured specific rotations with those reported in the literature.     

柠檬酸试剂中痕量无机阴阳离子的离子色谱法测定

选用柱容量较高、亲水性较强的阴离子分析柱IonPac AS18,以30mmol／L KOH为淋洗液,等度淋洗分析了高浓度柠檬酸中的痕量无机阴离子。选用柱容量较高的阳离子分析柱IonPac CS12A,以H2SO4作淋洗液分析了柠檬酸试剂中的痕量阳离子。在所选色谱条件下,无需样品前处理,直接进样,电导检测,高浓度柠檬酸不影响痕量阴离子或阳离子的测定。方法具有良好的线性(r=0．9941～1．000),样品中所测离子峰面积的相对标准偏差(RSD)均在9．0％以下(n=7),回收率在82．7％～110％之间,检出限低于3．7μg/L。     

基于IP核开发模式的高校集成电路设计发展策略研究

针对当前集成电路领域企业缺少原始技术积累、高校成果转化困难的问题，提出一种以IP核合作方式促进高校集成电路设计加快发展、实现高校企业双赢的创新机制。高校作为我国IC产业链中不可缺少的一部分，以西安交通大学SoC设计中心近十年来的发展历程为案例进行分析，提出基于IP核开发的高校集成电路设计发展的具体策略。     

PECL标准光收发器接口及应用

本文简介ＰＥＣＩ接口电路的最基本的技术，并给出一些 ＰＨＹ　ＩＣ与光收发器接口实例。     

Placement of Substrate Contacts to Minimize Substrate Noise in Mixed-Signal Integrated Circuits

The placement of substrate contacts in epi and non-epi technologies is analyzed in order to control and reduce the substrate noise amplitude and spreading. The choice of small or large substrate contacts or rings for each of the two major technologies is highlighted. Design guidelines for placing substrate contacts so as to improve the noise immunity of digital circuits in mixed-signal smart-power systems are also presented.     

New BIST Schemes for Structural Testing of Pipelined Analog to Digital Converters

Two alternative BIST schemes are proposed for structural testing of pipelined Analog-to-Digital Converters (ADC). They are oriented to fault detection in the converter stages rather than to measure the whole ADC electrical performance parameters. The operational principle of both strategies relies on testing every ADC stage reconfigured as an A/D-D/A block and applying as input a simple DC stimuli set which is easily obtained, without strong precision requirements, by a resistive network. The main differences between both strategies relate to the way the output response is evaluated. In the BIST#1 scheme, analog and digital outputs are compared with reference levels generated with a reference D/A converter and a counter. In the BIST#2 strategy, only digital outputs are available and they are compared with fault-free values previously stored in an on-chip register. The new techniques are intended to be used in pipelined converters of an arbitrary number of conversion stages and with a digital self-correction mechanism.     

磁场对反应离子刻蚀速率影响的研究

本文简要报道了P型衬底1.5μm隐埋新月型激光器的制备和特性,激光器在室温下连续工作的典型阈值电流为20mA低的为15mA,发射波长为1.53μm,最高连续工作温度105℃.     

PCB用高频（毫米波）材料与技术概述

文章概述了商用毫米波PCB材料的选择与技术。目前,商用微波设计走向毫米波体系并强烈要求薄型、高性能的基板材料。     

Direct separation of the enantiomers of ramosetron on a chlorinated cellulose‐based chiral stationary phase in hydrophilic interaction liquid chromatography mode

Ramosetron is an enantiopure active pharmaceutical ingredient marketed in Japan since 1996 and later in a few Southeast Asian countries predominantly as an antiemetic for patients receiving chemotherapy. In this study, a simple and rapid high‐performance liquid chromoatography method for the separation of ramosetron and its related enantiomeric impurity by using hydrophilic interaction liquid chromatography mode is presented. Chiral resolution was performed on an analytical column (100 mm × 4.6 mm id) packed with 3 μm particles of cellulose‐based Chiralpak IC‐3 chiral stationary phase. Using a mobile phase containing acetonitrile–water–diethylamine (100:10:0.1, v/v/v) and setting the column temperature at 35°C, the resolution value was 7.35. At a flow rate of 1 mL/min, the enantioseparation was completed within 5 min. The proposed method was partially validated and it has proven to be sensitive with limit of detection and limit of quantitation of the (S)‐enantiomer impurity of 44.5 and 133.6 ng/mL.     

Measurement selection for parametric IC fault diagnosis

This article presents experimental results which show feedforward neural networks are well-suited for analog IC fault diagnosis. Boundary band data (BBD) measurement selection is used to reduce the computational overhead of the FFN training phase. We compare the diagnostic accuracy between traditional statistical classifiers and feedforward neural networks trained with various measurement selection criteria. The feedforward networks consistently perform as well as or better than the other classifiers in term of accuracy. Training using BBD consistently reduces the FFN training efforts without degrading the performance. Experimental results suggest that feedforward networks provide a cost efficient method for IC fault diagnosis in a large scale production testing environment.This work is supported by NSF-IUC CDADIC, Project 90-1.