Temperature and pH dual‐sensitive polyaspartamide derivatives for antitumor drug delivery

The pH‐sensitive tertiary amino groups were introduced to synthesize temperature and pH dual‐sensitive degradable polyaspartamide derivatives (phe/DEAE‐g‐PHPA) containing pendant aromatic structures and ionizable tertiary amino groups. The thermo/pH‐responsive behavior of phe/DEAE‐g‐PHPA polymer can be tuned by adjusting the graft copolymer composition. Due to the pH sensitivity of the phe/DEAE‐g‐PHPA‐g‐mPEG polymer with hydrophilic long PEG chain, the micelles and the anticancer drug‐loaded micelles were prepared by a quick pH‐changing method without using toxic organic solvent. The obtained polymeric micelles, paclitaxel‐loaded micelles and doxorubicin‐loaded micelles were stable under physiological conditions. Both the drug‐loaded micelles showed much faster release at pH 5 than at pH 7.4. The doxorubicin‐loaded micelles showed obvious and better anticancer activity against both HepG2 and HeLa cells than free doxorubicin. Thus these nontoxic, dual thermo‐ and pH‐sensitive phe/DEAE‐g‐PHPA‐g‐mPEG micelles may be a promising anticancer drug delivery system. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54, 879–888     

基于DID模型的ITS对北京交通拥堵改善的研究:评价期的视角

采用双重差分模型,基于智能交通系统(ITS)效用发挥滞后时间为3年,选择2010年和2014年作为评价时点对ITS实施效果和北京交通拥堵之间的相关性进行分析.DID模型计量分析的最终结果显示,ITS效果的发挥明显改善了北京交通拥堵问题.为了验证评价结果的可信度,通过改变评价时点这一参数对评价结果进行稳健性检验,结果仍显示ITS效应发挥对北京交通拥堵改善有很大的促进作用.     

Construction and application of photoresponsive smart nanochannels

In living organisms, many biological processes are inextricably linked with light, such as the photosynthesis systems and rhodopsin. Hence, construction of light-sensitive biomimetic-nanochannels, which can realize the functions of cells and other membrane structures with high degree of spatial and temporal control, is particularly attractive and challenging. As a cornerstone of light-sensitive nanochannels, the photoresponsive materials are a big family and at their mature stage after several decades of development, which can provide different strategies to construct biomimetic photoresponsive nanochannels. In this review, we mainly summarize the construction and applications of photoresponsive nanochannels on the basis of various photoresponsive materials. The construction of photoresponsive nanochannels can be classified into four categories: photoresponsive inorganic nanochannels based on inorganic-compound-based photonic sensitive materials; photoresponsive organic nanochannels based on organic-compound-based photonic sensitive materials; photoresponsive polymers nanochannel based on photoresponsive polymers materials and potential photoresponsive nanochannels based on other photoresponsive materials. After introducing the construction of photoresponsive nanochannels, the review highlights some of the most recent applications of photoresponsive nanochannels in separation, energy conversion and storage, drug delivery and so on.     

数据整合技术在水路运政业务中的研究与应用

本文主要从信息化的角度，在水路运政中进行数据整合技术的研究与应用。     

带凹性生产成本运输问题的新随机规划模型及其求解

提出了一种新的能反映决策者满意度的随机变量序关系,并据此研究了随机不等式的确定性等价类,方法被称为满意度方法.最后将其应用于带凹性生产成本运输问题的求解中,并将方法与常用的机会约束方法进行比较,说明满意度法不仅合理可行,而且当决策者对约束条件的要求越高时,它所得最优值越优于机会约束法所得最优值.     

Corresponding Angle Feedback in an innovative weighted transportation system

The optimal information feedback has a significant effect on many socioeconomic systems like stock market and traffic systems aiming to make full use of resources. In this Letter, we study dynamics of traffic flow with real-time information. The influence of a feedback strategy named Corresponding Angle Feedback Strategy (CAFS) is introduced, based on a two-route scenario in which dynamic information can be generated and displayed on the board to guide road users to make a choice. Our model incorporates the effects of adaptability into the cellular automaton models of traffic flow and simulation results adopting this optimal information feedback strategy have demonstrated high efficiency in controlling spatial distribution of traffic patterns compared with the other three information feedback strategies, i.e., vehicle number and flux.     

基于智能手机的移动学习系统开发技术研究

移动学习逐步成为成人远程教育重要的学习方式,本文针对开发基于智能手机的移动学习系统,在探讨移动学习及其网络架构的基础上,采用实例分析法,对现阶段开发移动学习系统的各种技术进行了分析,重点剖析了现阶段开发移动学习系统的开发模式及其技术架构的实现。这些技术和方法,对技术人员进行移动学习系统的开发具有指导和借鉴意义。     

太阳能多功能控氧家居系统

介绍了以STC15F2K61S2为控制核心,通过太阳能或者可充电电池供电,并采集蓝牙模块、氧气传感器、DS18B20温度传感器等传感器数据数据,然后经过处理芯片对数据进行进行数据处理及分析,将相关数据显示在12864液晶显示屏上,同时在安卓手机安装手机通信助手软件,或者结合电脑利用RS232串口与单片机进行通信,便可对家电进行相应的操作,从而实现家居智能化控制的目的.     

基于LabVIEW的车辆监测系统的设计

基于National Instructionals公司的LabVIEW虚拟仪器技术,设计和搭建了车辆监测系统。利用车载GPS/北斗定位接收系统获取定位信息,通过GPRS将定位信息传递至监控台,监控台将信息汇总后返回至每一车辆,将所有车辆的位置信息共享并显示。监测及显示软件通过LabVIEW编写,以期实现车辆运行状况的实时监控。实验结果表明,该系统能够精确有效地监测和显示车辆的运行状况。     

社交网络智慧搜索研究进展与发展趋势

在以社交网络为代表的Web 2.0时代,搜索需求已经远超出Web 1.0搜索引擎的能力范畴,数据具有模式多态、快速产生、动态交互、碎片化、变化演绎等特点,这些新特点给搜索引擎技术带来了革命性和颠覆性的挑战。归纳了在线社交网络智慧搜索研究进展和技术要点,分析了研究发展过程将面临3个主要问题：在线社交网络中智慧与知识的发掘与推演、用户真实搜索意图的理解与表示以及满足用户真实意图的智慧解答在线响应,并以解决此3个问题为目标讨论了相关技术发展。