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51.
工业化发展导致了脆弱的土地进一步沙漠化,沙漠地区政府应综合考虑经济发展与土地沙漠化导致的生态质量降低。通过构建两个沙漠化地区微分博弈模型,研究了两个地区的沙漠治理问题。研究结果表明,提高工业生产排放技术或沙漠治理技术均能够提高均衡经济产出水平,在工业生产收益系数较高的情况下也能够提高沙漠治理投入水平,并且两种技术提高存在交互效应;只有对生产排放技术水平和沙漠治理技术水平较高的地区,延长地方政府领导任期有利于沙漠治理;实现沙漠完全治理情况下控制土地再沙化的治理投入低于控制沙漠稳定在一定规模的治理投入。 相似文献
52.
Jue Ling Tingting Huang Ronghua Wu Chao Ma Ge Lin Zhihao Zhou Junpei Wang Qifeng Tu Xiaoxuan Tang Yan Liu Mei Liu Liu Yang Yumin Yang 《Advanced functional materials》2023,33(14):2213342
Due to the complex spatial-temporal pathophysiology of spinal cord injury (SCI), effective modulation of SCI-specific inflammatory pathogenesis to achieve desirable therapeutic effects on functional recovery still remains challenging. Herein, cell-enhanced photocrosslinked silk fibroin hydrogels with extracellular matrix-mimicking cues of mechanical properties and RGD (Arg-Gly-Asp) signals are gelled in situ to fill the lesion site to modulate injury-induced neuroinflammation and promote neurite regrowth after SCI. The bionic hydrogel system provides biomimetic mechanical cues to promote neuronal differentiation of neural stem/progenitor cells (NPCs) and neurite growth by activating YAP nuclear expression. Importantly, favored by the strong capacity of silk fibroin hydrogels on macrophage/microglia recruitment, NPCs encapsulated hydrogel (NPCs@SFRGD0.1) effectively promotes recruited macrophages/microglia to M2 polarization in the lesion site by releasing S100A4 and thereby remodels the inflammatory microenvironment after SCI. Moreover, NPCs@SFRGD0.1 successfully reduces glial scar formation and accelerates corticospinal tract axon regrowth to improve locomotor recovery. Overall, this work contributes to illustrating the therapeutic mechanism of NPCs development based biomaterial therapies on modulating inflammatory microenvironment and this NPCs enhanced silk fibroin hydrogel provides a promising therapeutic strategy for SCI. 相似文献
53.
Erji Gao Yao Wang Pengli Wang Qianyi Wang Yuxuan Wei Daiying Song Huangfang Xu Jinghao Ding Yong Xu Huitang Xia Ru Chen Liang Duan 《Advanced functional materials》2023,33(14):2212830
A highly biomimetic neotrachea with C-shaped cartilage rings has promising clinical applications in the treatment of circumferential tracheal defects (CTDs) owing to its structure and physiological function. However, to date, most fabricated tracheal cartilages are O-shaped. In this study, finite element analysis demonstrates C-shaped cartilage rings that exhibit better compliance than O-shaped. Hydrogel is developed using methacryloyl-modified decellularized Wharton's jelly matrix (DWJMA) for the regeneration of C-shaped cartilage rings. This novel hydrogel possesses adjustable physicochemical properties and favorable cytocompatibility. When loaded with chondrocytes, DWJMA hydrogels support the optimal cartilage regeneration both in vitro and in vivo. More importantly, a highly biomimetic neotrachea simultaneously simulating the structural and physiological properties of the normal trachea is regenerated via modular assembly of several individual C-shaped cartilage rings. The results demonstrate the highly biomimetic neotrachea have better patency (88.6 ± 6.1% vs 74.4 ± 9.4%, p < 0.05), improve the survival rate, alleviate weight loss and mucoid impaction, than its O-shaped counterpart when used for the treatment of CTDs in a rabbit model. Therefore, this study proposes a novel hydrogel for the regeneration of C-shaped cartilage and provides new insights into the treatment of CTDs using a highly biomimetic neotrachea with C-shaped cartilage rings. 相似文献
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微量元素对胎儿发育影响的临床研究 总被引:6,自引:0,他引:6
为了解小于胎龄儿的血锌、铜、铅的变化 ,对 3 8例小于胎龄儿 (其中 1 2例有先天缺陷 )进行了血锌、铜、铅三种微量元素检测 ,并与 3 1例健康足月适于胎龄儿比较。结果表明 ,3 8例小于胎龄儿血锌、铜、铅结果分别为 49 4± 1 9 88μmol/L、 1 0 7± 3 3 μmol/L、 1 5± 0 83 μmol/L ;与正常对照组 (分别为 62 3 9± 1 5 2 9μmol/L、 1 1 0 2± 1 73 μmol/L、 0 82± 0 3 9μmol/L)比较 ,血锌明显低于正常组 ,t=-2 88,P <0 0 1 ;血铅明显高于对照组 ,t =4 6,P <0 0 1 ,有显著性差异。两组血铜无明显差异。小于胎龄儿血锌降低 ,血铅增高 ,而且其先天性缺陷者占3 5 .5 8% ,证明胎儿的低锌高铅状态对其生长发育有重要影响。 相似文献
57.
微量元素锌促进儿童生长发育临床研究 总被引:1,自引:0,他引:1
报道以微量元素锌治疗缺锌患儿118例并与114例作对照观察.结果发现,衡量生长发育与营养的敏感指标:身高、体重、血清白蛋白及血色素等参数,治疗组比对照组都显著提高(P值<0.01).证明锌制剂对缺锌儿童有显著的促进生长发育及改善营养状态作用,作者并对锌的作用机理作了论述. 相似文献
58.
为分析铁缺乏症(IDD)对婴幼儿智能发育的影响,随机抽取了6个月至3岁婴幼儿200例,按有否铁缺乏分组,比较了其与智能的关系。结果表明,铁缺乏症检出率为17.5%,铁缺乏组婴幼儿智能发育商(DQ)明显下降,与正常组比较差异有显著性,铁缺乏程度越重,DQ值越低。可见铁缺乏症对婴幼儿大脑发育造成不良影响,对该症无贫血阶段及轻度缺铁性贫血期(IDA)应予重视。 相似文献
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《Arabian Journal of Chemistry》2022,15(11):104262
This review critically evaluates the plastic accumulation challenges and their environmental (primarily) and human (secondarily) impacts. It also emphasizes on their degradation and fragmentation phenomena under marine conditions. In addition, it takes into account the leachability of the various chemical substances (additives) embedded in plastic products to improve their polymeric properties and extend their life. Regardless of their effectiveness in enhancing the polymeric function of plastic products, these additives can potentially contaminate air, soil, food, and water. Several findings have shown that, regardless of their types and sizes, plastics can be degraded and/or fragmented under marine conditions. Therefore, the estimation of fragmentation and degradation rates via a reliable developed model is required to better understand the marine environmental status. The main parameter, which is responsible for initiating the fragmentation of plastics, is sunlight/UV radiation. Yet, UV- radiation alone is not enough to fragment some plastic polymer types under marine conditions, additional factors are needed such as mechanical abrasion. It should be also mentioned that most current studies on plastic degradation and fragmentation centered on the primary stages of degradation. Thus, further studies are needed to better understand these phenomena and to identify their fate and environmental effects. 相似文献