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841.
Jnos Vetter 《Molecules (Basel, Switzerland)》2022,27(19)
Previous studies related to the ptaquiloside molecule, a carcinogenic secondary metabolite known from the world of ferns, are summarised. Ptaquiloside (PTA) belongs to the group of norsesquiterpenes of the illudane type. The name illudane refers to the fungal taxa from which the first representatives of the molecular group were identified. Ptaquiloside occurs mainly in Pteridium fern species, although it is also known in other fern taxa. The species of the genus Pteridium are common, frequent invasive species on all continents, and PTA is formed in smaller or larger amounts in all organs of the affected species. The effects of PTA and of their derivatives on animals and humans are of great toxicological significance. Its basic chemical property is that the molecule can be transformed. First, with the loss of sugar moiety, ptaquilosine is formed, and then, under certain conditions, a dienone derivative (pteridienone) may arise. The latter can alkylate (through its cyclopropane groups) certain molecules, including DNA, in animal or human organisms. In this case, DNA adducts are formed, which can later have a carcinogenic effect through point mutations. The scope of the PTA is interdisciplinary in nature since, for example, molecules from plant biomass can enter the body of animals or humans in several ways (directly and indirectly). Due to its physico-chemical properties (excellent water solubility), PTA can get from the plant into the soil and then into different water layers. PTA molecules that enter the soil, but mainly water, undergo degradation (hydrolytic) processes, so it is very important to clarify the toxicological conditions of a given ecosystem and to estimate the possible risks caused by PTA. The toxicoses and diseases of the animal world (mainly for ruminant farm animals) caused by PTA are briefly described. The intake of PTA-containing plants as a feed source causes not only various syndromes but can also enter the milk (and meat) of animals. In connection with the toxicological safety of the food chain, it is important to investigate the transport of carcinogenic PTA metabolites between organisms in a reassuring manner and in detail. This is a global, interdisciplinary task. The present review aims to contribute to this. 相似文献
843.
Tuoc Phan & Yannick Sire 《分析论及其应用》2020,36(2):111-127
We establish local and global well-posedness of the 2D dissipative quasi-geostrophic equation in critical mixed norm Lebesgue spaces. The result demonstrates
the persistence of the anisotropic behavior of the initial data under the evolution of
the 2D dissipative quasi-geostrophic equation. The phenomenon is a priori nontrivial
due to the nonlocal structure of the equation. Our approach is based on Kato's method
using Picard's iteration, which can be adapted to the multi-dimensional case and
other nonlinear non-local equations. We develop time decay estimates for solutions of
fractional heat equation in mixed norm Lebesgue spaces that could be useful for other
problems. 相似文献
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A trust-region sequential quadratic programming (SQP) method is developed and analyzed for the solution of smooth equality constrained optimization problems. The trust-region SQP algorithm is based on filter line search technique and a composite-step approach, which decomposes the overall step as sum of a vertical step and a horizontal step. The algorithm includes critical modifications of horizontal step computation. One orthogonal projective matrix of the Jacobian of constraint functions is employed in trust-region subproblems. The orthogonal projection gives the null space of the transposition of the Jacobian of the constraint function. Theoretical analysis shows that the new algorithm retains the global convergence to the first-order critical points under rather general conditions. The preliminary numerical results are reported. 相似文献
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本文研究了一个P0非线性互补问题.利用信赖域技术获得了求解该问题的光滑Levenberg-Marquardt算法,该算法在一定条件下具有全局性.利用局部误差界还获得了该算法的超线性和二次收敛.数值结果表明该算法是有效的. 相似文献