肾小球滤过率活体实时监测荧光示踪剂的研究进展

急性肾损伤是一种临床常见的急性疾病. 通过外源性的荧光示踪剂对肾小球滤过率进行非侵入性的实时监测, 对于及时了解易患病人的肾脏功能具有重要的临床价值和应用前景. 本文综合评述了用于活体检测肾小球滤过率的外源性荧光示踪剂的近期研究进展, 重点介绍了荧光示踪剂的设计策略及其活体成像应用效果, 并对相应检测装置的发展进行了阐述, 同时对该领域的挑战与发展前景进行了展望.     

振荡抽滤-pH计指示电位滴定法快速测定土壤样品中阳离子交换总量

为了提高土壤中阳离子交换量(CEC)分析效率及分析准确度,采用乙酸铵或氯化铵-乙酸铵溶液对土壤样品进行处理,并采用振荡交换、抽滤分离的方式进行离子交换、铵离子清洗.土壤饱和吸附的铵离子用甲醛-C aC l2溶液交换后,采用氢氧化钠溶液滴定,并用p H计准确指示滴定终点,由此测定C EC含量.选用5个国家一级有效态标准物...     

Graded Differential Equations and Dirac Type Operators

Singularities of solutions of graded differential equations as filtrations are studied. Symbols and the transfer operator associated with the h-adic filtration are computed. The condition that the transfer operator is a differential operator over the characteristic manifold of codimension 1 for this filtration is given. The Dirac operator is introduced by using the De Broglie principle: singularities of wave-like solutions move as material points. Use of the transfer operator associated with the h-adic filtration implies an invariant definition of the Pauli operator. A natural parallel translation arises as quantum analog of the Levi-Civita connection.     

Optimizing air purification for household particulate matters using sensor-based and time-based intervention strategies

Filtration efficiency of portable air cleaner (PAC) is affected by resident perceptions and adherences to when and how to operate the PAC. Incorporating PAC with smart control and sensor technology holds the promise to effectively reduce indoor air pollutants. This study aims to evaluate the efficiency of a PAC at removing indoor fine particulate matters (PM_2.5) exposure under two automated operation settings: (1) a time-based mode in which the operation time is determined based on perceived time periods of indoor pollution by residents; (2) a sensor-based mode in which an air sensor monitor is used to determine the PAC based on the actual PM_2.5 level against the indoor air quality guideline. The study was conducted in a residential room for 55 days with a rolling setting on PAC (no filtration, sensor-based, time-based filtrations) and a continuous measurement of PM_2.5. We found that the PAC operated with sensor-based mode removed PM_2.5 concentrations by 47% and prolonged clean air (<35 μg/m³) period by 23% compared to the purifications with time-based mode which reduced PM_2.5 by 29% and increased clean air period by 13%. The sensor-based filtration identified indoor pollution episodes that are hardly detected by personal perceptions. Our study findings support an automated sensor-based approach to optimize the use of PAC for effectively reducing indoor PM_2.5 exposure.     

ad-NILPOTENT ELEMENTS, QUASI-NILPOTENT ELEMENTS AND INVARIANT FILTRATIONS OF INFINITE DIMENSIONAL LIE ALGEBRAS OF CARTAN TYPE

Let F be an arbitrary field of characteristic p≠2, and L be an infinite Lie, algebra ofCartan type (graded or complete). When p>3 (or p is arbitrary), the set of ad-nilpotent(or quasi-nilpotent) elements of L is determined. Consequently, it is proved that the naturalfiltration and the noncontractible filtration of L are invariant.     

Methylated arsenic species in estuarine porewaters

Inorganic arsenic, monomethylarsenic and dimethylarsenic species have been observed in samples of sediment porewater collected from the Tamar Estuary in South-West England. Porewater samples were collected using in situ dialysis. The arsenic species were separated by hydride generation and concentrated by liquid nitrogen trapping, prior to analysis by directly coupled gas chromatography-atomic absorption spectroscopy. The predominant dissolved arsenic species present was inorganic arsenic (5-62 m?g dm^?3). However, this is the first time significant concentrations of methylated arsenic species have been quantified in estuarine porewaters (0.04–0.70 m?g dm^?3), accounting for between 1 and 4% of the total dissolved arsenic. The presence of methylated arsenic compounds in porewaters is attributed to in situ environmental methylation, although the possibility of methylated arsenic species being derived from biological debris cannot be excluded.     

Conditioned stochastic differential equations: theory, examples and application to finance

We generalize the notion of Brownian bridge. More precisely, we study a standard Brownian motion for which a certain functional is conditioned to follow a given law. Such processes appear as weak solutions of stochastic differential equations that we call conditioned stochastic differential equations. The link with the theory of initial enlargement of filtration is made and after a general presentation several examples are studied: the conditioning of a standard Brownian motion (and more generally of a Markov diffusion) by its value at a given date, the conditioning of a geometric Brownian motion with negative drift by its quadratic variation and finally the conditioning of a standard Brownian motion by its first hitting time of a given level. As an application, we introduce the notion of weak information on a complete market, and we give a “quantitative” value to this weak information.     

Tangential flow filtration for virus purification

Purification of virus particles and viral vectors for viral vaccines and gene therapy applications is a major large-scale separations challenge. Purification of parvovirus particles such as adeno-associated virus, the leading candidate for gene therapy applications, is particularly challenging given their small size, typically 18–26 nm. We have investigated the use of ultrafiltration for purification of Aedes aegypti densonucleosisvirus, a mosquito parvovirus.     

Modeling and optimization of membrane lifetime in dead-end ultra filtration

In this paper, a membrane lifetime model is developed and experimentally validated. The lifetime model is based on the Weibull probability density function. The lifetime model can be used to determine an unambiguous characteristic membrane lifetime. Experimental results showed that membrane lifetime shortens if the average membrane fouling status increases. The lifetime modeling results are then used to determine the economic lifetime of membranes. Subsequently, the economic lifetime of a membrane is used to optimize membrane lifetime, i.e. minimizing the total costs. Based on the experimental results it can be concluded that the total costs are minimal if the average membrane fouling status is approximately 1.7× the membrane resistance.