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61.
Tayel A. Al Hujran Mousa K. Magharbeh Almeqdad Y. Habashneh Rasha S. Al-Dmour Ashraf Aboelela Hesham M. Tawfeek 《Molecules (Basel, Switzerland)》2022,27(14)
The study aims to assess the interaction between fluconazole and sulfonatocalix[4]naphthalene towards enhancing its dissolution performance and antimycotic activity. A solubility study was carried out at different pH conditions, and the results revealed the formation of a 1:1 molar ratio fluconazole-sulfonatocalix[4]naphthalene inclusion complex with an AL type phase solubility diagrams. The solid powder systems of fluconazole-sulfonatocalix[4]naphthalene were prepared using kneaded and co-evaporation techniques and physical mixtures. DCS, PXRD, TGA-DTG, FT-IR, and in vitro dissolution performance characterize the prepared systems. According to physicochemical characterization, the co-evaporation approach produces an amorphous inclusion complex of the drug inside the cavity of sulfonatocalix[4]naphthalene. The co-evaporate product significantly increased the drug dissolution rate up to 93 ± 1.77% within 10 min, unlike other prepared solid powders. The antimycotic activity showed an increase substantially (p ≤ 0.05, t-test) antimycotic activity of fluconazole co-evaporate mixture with sulfonatocalix[4]naphthalene compared with fluconazole alone against clinical strains of Candida albicans and Candida glabrata. In conclusion, sulfonatocalix[4]naphthalene could be considered an efficient complexing agent for fluconazole to enhance its aqueous solubility, dissolution performance, and antimycotic activity. 相似文献
62.
63.
Noether-Mei Symmetry of Mechanical System in Phase Space 总被引:1,自引:0,他引:1
In this paper, a new kind of symmetry and its conserved
quantities of a mechanical system in phase space are studied.
The definition of this new symmetry, i.e., a Noether-Mei symmetry,
is presented, and the criterion of this symmetry is also given.
The Noether conserved quantity and the Mei conserved quantity
deduced from the Noether-Mei symmetry of the system are obtained.
Finally, two examples are given to illustrate the application of the results. 相似文献
64.
65.
钾明矾(KAl(SO4)2·12H2O)有较高的潜热和良好的导热性(熔化热232.4kJ/kg,导热系数为0.55W/m·K),熔点为91℃,是中低温相变材料中较有开发价值的一种.但是它的过冷度高达19.8℃,并且由于相变过程伴随着结晶水的蒸发使无机盐的使用寿命大大降低.本文通过冷指法及添加成核剂的方法对硫酸铝钾的过冷现象进行了研究,结果表明成核剂NiSO4·6H2O、MgCl2·6H2O能较好的改善过冷现象,当MgCl2·6H2O的添加量为2;时可使过冷度降为零,且能保持钾明矾的相变温度而不使其降低.利用MgCl2·6H2O具有很强的吸湿性,可以补充相变过程中损失的水分,使相变材料的使用寿命大大提高. 相似文献
66.
在太赫兹通信的超宽带应用场景下,太赫兹载波是通过多次倍频实现,因而导致相噪严重恶化。基于太赫兹频率下的多极/零相位噪声模型,在传统的盲相位估计算法的基础上,提出了一种全并行化的相位估计算法。该算法通过在每个并行数据中插入导频,将导频相噪信息作为初始相位对并行数据进行相位扩展及旋转鉴相。借鉴传统盲相位估计算法的最佳相位估计值的判决选择思路,同时利用前一时刻导频和当前时刻导频,对当前并行数据从前后两个方向进行相位估计并对前后两个估计相位基于距离前后导频的位置进行加权求和以获得最佳相位估计信息。经过仿真验证,通过该算法后残余相噪在1 MHz和10 MHz处分别降低10 dBc/Hz和25 dBc/Hz。 相似文献
67.
This paper reports the development and validation of an assay for the determination of acetonitrile in the recycled mobile phase using high performance liquid chromatography(HPLC). The method is based on that the retention in reversed-phase liquid chromatography increases with decreasing concentration of organic phase in the mobile phase. The natural logarithm of the capacity ratio for a given solute is linearly related to the volume fraction of the organic modifier in the mobile phase. For dimethylphthalate and diethylphthalate, the linearity range is 30%--60%, and for biphenyl and terphenyl, the range is 60%--95%. Precision values(RSD) were both 〈1% and the accuracy(RE) was in the range of ±1%. The assay was successfully applied to the determination of acetonitrile concentration of recycled mobile phase after the distillation of the column eluent in our laboratory. 相似文献
68.
The 8-iso-prostaglandin F2α (8-iso-PGF2α) biomarker is used as the gold standard for tracing lipid oxidative stress in vivo. The analysis of urinary 8-iso-PGF2α is challenging when dealing with trace amounts of 8-iso-PGF2α and the complexity of urine matrixes. A packed-fiber solid-phase extraction (PFSPE)–coupled with HPLC-MS/MS–method, based on polystyrene (PS)-electrospun nanofibers, was developed for the specific determination of 8-iso-PGF2α in urine and compared with other newly developed LC-MS/MS methods. The method, which simultaneously processed 12 samples within 5 min on a self-made semi-automatic array solid-phase extraction processor, was the first to introduce PS-electrospun nanofibers as an adsorbent for the extraction of 8-iso-PGF2α and was successfully applied to real urine samples. After optimizing the PFSPE conditions, good linearity in the range of 0.05–5 ng/mL with R2 > 0.9996 and a satisfactory limit of detection of 0.015 ng/mL were obtained, with good intraday and interday precision (RSD < 10%) and recoveries of 95.3–103.8%. This feasible method is expected to be used for the batch quantitative analysis of urinary 8-iso-PGF2α. 相似文献
69.
70.
提出了一种产生高消光比超短光脉冲的新方法.利用相位调制器调制连续光生成啾啁光,而后利用M-Z强度调制器的倍频调制抑制对压缩不利的啁啾部分的影响,再通过等效啁啾光纤光栅进行压缩产生光脉冲.理论和仿真结果表明,该方法可以很好地消除光脉冲的基底及减小旁辦,产生消光比大于30 dB、波形理想的光脉冲,具有很强的可实现性.最后利用实际制作的色散系数为-380 ps/nm的等效啁啾光纤光栅对该方法进行了实验验证,结果表明,在重复频率为2.5 GHz、相位调制系数为9时,可产生脉宽小于18 ps的高质量光脉冲. 相似文献