Effective synthesis of bicyclodienes via palladium-catalyzed asymmetric allylic alkylation and ruthenium-catalyzed cycloisomerization

[n.3.0]Bicycles (n = 3–6) can be synthesized using palladium-catalyzed asymmetric allylic alkylation followed by ruthenium-catalyzed cycloisomerization. New types of triarylphosphino-1,2-diaminooxazoline ligands show the same high levels of enantioselectivity observed with Trost ligand when employed in Pd-catalyzed allylic alkylation reactions. The enyne products of these allylic alkylation reactions were further elaborated using a Ru-catalyzed redox isomerization process, for which a mechanism is proposed.     

电信运营商市场监控告警系统的构建和应用

本文针对电信运营商之间激烈的市场竞争,提出了深挖企业内部资源,建立电信运营商市场监控告警系统的必要性.文章提出了建立电信企业市场发展指标体系,重点介绍了如何针对指标的发展变化进行跟踪监控,并利用基于偏差的异常数据检测方法设置指标告警门限,对异常情况进行告警.最后介绍了电信运营商市场监控告警系统的架构和主要功能模块.     

电子信息产品环境适应性标准的现状及需求

环境适应性是电子信息产品重要的质量属性之一。通过对环境适应性技术及其标准发展的概况阐述,介绍了国内外电子信息产品环境适应性领域标准的现状和现有标准的需求情况。     

微流控芯片计算机辅助设计、辅助制造方法研究

介绍了一种采用计算机辅助制造中快速成型技术实现微流控芯片快速制作的方法。采用VB二次开发工具(VBA),在计算机辅助设计(CAD)二次开发平台上建立微流控芯片三维CAD立体模型,并通过计算机软件算法对CAD模型进行分层切片,为实现微流控芯片计算机辅助制造提供加工数据。文中针对微流控芯片加工精度要求高的特点,提出了采用位图数据图像格式(BMP)数据格式取代快速成型分层切片中常用的三角面片数据格式(STL),并对具体实现方法进行了详细介绍。     

光纤陀螺的发展现状

介绍了光纤陀螺的原理特点和发展过程,着重描述和总结了光纤陀螺在国内外发展的技术趋势和产业化情况。可以看到,随着现代微电子技术、光电子技术和信号处理技术的发展,光纤陀螺在未来惯性测量领域中占据越来越重要的位置。     

2005年我国LED显示屏产业发展综述

文章总结了2005年国内LED显示屏产业发展总体情况,对LED显示屏产业和市场发展进行了分析,介绍了LED显示屏产业技术和标准化进展,展望了LED显示屏产业的未来发展趋势。     

国内外三坐标雷达发展现状

三坐标雷达可获得目标距离、方位及仰角等参数．和两坐标雷达相比具有更大的探测范围和更好的目标分辨能力。当代新型三坐标雷达具有搜索范围大、数据率高、反应时间短等特点。介绍了三坐标雷达普遍采用的技术,并列举了国内外几种三坐标雷达。     

GaN薄膜制备及脉冲激光沉积法的研究进展

介绍了国内外制备GaN材料的历史和现状。分析了GaN材料及其薄膜的各种制备工艺的特点,并详细介绍了采用激光沉积工艺制备GaN薄膜的研究进展。     

Development and Validation of a Reliable UHPLC-MS/MS Method for Simultaneous Quantification of Macrocyclic Lactones in Bovine Plasma

A fast, accurate and reliable ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS) method was developed for simultaneous quantification of ivermectin (IVER), doramectin (DORA), and moxidectin (MOXI) in bovine plasma. A priority for sample preparation was the eradication of possible infectious diseases to avoid travel restrictions. The sample preparation was based on protein precipitation using 1% formic acid in acetonitrile, followed by Ostro^® 96-well plate pass-through sample clean-up. The simple and straightforward procedure, along with the short analysis time, makes the current method unique and suitable for a large set of sample analyses per day for PK studies. Chromatographic separation was performed using an Acquity UPLC HSS-T3 column, with 0.01% acetic acid in water and methanol, on an Acquity H-Class ultra-high performance liquid chromatograph (UHPLC) system. The MS/MS instrument was a Xevo TQ-S^® mass spectrometer, operating in the positive electrospray ionization mode and two multiple reaction monitoring (MRM) transitions were monitored per component. The MRM transitions of m/z 897.50 > 753.4 for IVER, m/z 921.70 > 777.40 for DORA and m/z 640.40 > 123.10 for MOXI were used for quantification. The method validation was performed using matrix-matched calibration curves in a concentration range of 1 to 500 ng/mL. Calibration curves fitted a quadratic regression model with 1/x2 weighting (r ≥ 0.998 and GoF ≤ 4.85%). Limits of quantification (LOQ) values of 1 ng/mL were obtained for all the analytes, while the limits of detection (LOD) were 0.02 ng/mL for IVER, 0.03 ng/mL for DORA, and 0.58 ng/mL for MOXI. The results of within-day (RSD < 6.50%) and between-day (RSD < 8.10%) precision and accuracies fell within acceptance ranges. No carry-over and no peak were detected in the UHPLC-MS/MS chromatogram of blank samples showing good specificity of the method. The applicability of the developed method was proved by an analysis of the field PK samples.