The Behaviors of Ferro-Magnetic Nano-Particles In and Around Blood Vessels under Applied Magnetic Fields

In magnetic drug delivery, therapeutic magnetizable particles are typically injected into the blood stream and magnets are then used to concentrate them to disease locations. The behavior of such particles in-vivo is complex and is governed by blood convection, diffusion (in blood and in tissue), extravasation, and the applied magnetic fields. Using physical first-principles and a sophisticated vessel-membrane-tissue (VMT) numerical solver, we comprehensively analyze in detail the behavior of magnetic particles in blood vessels and surrounding tissue. For any blood vessel (of any size, depth, and blood velocity) and tissue properties, particle size and applied magnetic fields, we consider a Krogh tissue cylinder geometry and solve for the resulting spatial distribution of particles. We find that there are three prototypical behaviors (blood velocity dominated, magnetic force dominated, and boundary-layer formation) and that the type of behavior observed is uniquely determined by three non-dimensional numbers (the magnetic-Richardson number, mass Péclet number, and Renkin reduced diffusion coefficient). Plots and equations are provided to easily read out which behavior is found under which circumstances ( Fig. 5, Fig. 6, Fig. 7 and Fig. 8). We compare our results to previously published in-vitro and in-vivo magnetic drug delivery experiments. Not only do we find excellent agreement between our predictions and prior experimental observations, but we are also able to qualitatively and quantitatively explain behavior that was previously not understood.     

X光辐射在泡沫介质中超声速传输研究进展

X光辐射输运过程通过光子的发射与吸收使能量在介质内进行再分配,而光子的辐射和吸收过程对从介质内出射的能谱产生十分显著的影响。辐射输运由积分-微分方程来描述,得到它的解极其困难,这是因为此方程依赖于局域和非局域的条件。当外加的非局域的X光辐射场作用在介质上一个强的X光辐射能流时,介质的局域温度和密度将影响X光的吸收和发射。本文将对辐射输运的方程和基本理论进行阐述,并对辐射超声速传输的实验结果进行评述。首先,介绍辐射在介质中的传输的理论基础以及简化分析模型;其次,对辐射在介质中扩散超声速输运进行解析分析,我们首次导出辐射的超声速传输条件下的辐射能流与物质能流之比与马赫数和光学厚度的定量关系;最后,介绍国外的主要实验结果,同时也给出我们近期的研究结果。我们的实验结果表明,不同能区的光子因辐射不透明度不同使得在介质中的传播时间不同,并且实验测出光学厚度。     

共聚焦拉曼测量中激光焦点在球形液滴中的穿透深度

针对在共聚焦拉曼测量中激光在球形液滴中的聚焦问题建立理论模型, 推导出激光焦点在球形液滴中的穿透深度公式, 将激光焦点在球形液滴中的实际穿透深度和拉曼平台的垂直移动距离关联起来. 研究表明, 平台移动距离和激光焦点移动距离是非线性的, 激光焦点分别聚焦于液滴上表面和球心处时, 激光焦点的移动距离等于平台移动距离, 而当激光焦点在液滴上表面和液滴球心之间时, 激光焦点的移动距离大于平台移动距离. 并利用此结论初步获得MgSO₄球形液滴胶态结构的空间分布信息. 发现MgSO₄液滴在低湿度下形成的胶态结构是具有一定厚度的壳状结构, 且其厚度与液滴所处环境的相对湿度有关.     

Preparation of polyurethane elastomers (PUEs) in a high‐throughput workflow

High‐throughput experimentation (HTE) represents a promising and versatile approach for polyurethane (PU) research as a tool to rapidly screen and characterize a large number of samples in an automated way. To realize a unique HTE workflow for the research and development of PU elastomers (PUEs), the use of parallel automated formulation and coating platforms at Flamac were explored. To evaluate the applicability of HTE for PUEs, four different PU systems were investigated with different reactivities and viscosities. All prepared PUEs were evaluated by conventional physical testing methods measuring the E‐modulus, tensile‐elongation and the hardness properties revealing similar trends as conventionally prepared PUEs indicating the viability of the HTE approach. In addition, the properties of the PUEs were also investigated using downscaled microtensile bars as well as depth‐sensing indentation, again, revealing similar trends. With this proof of principle study, we demonstrated for the first time that HTE can also be extended to polymeric materials based on high reactive and viscous raw materials in combination with complex technologies. The reported results provide a basis for the use of HTE approaches for preparing, screening and characterizing large numbers of PUEs for R&D purposes. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011     

基于光学厚度的云红外辐射计算

 为了研究不同物理厚度和不同波段下云的红外辐射特性,提出了基于光学厚度的云红外辐射计算方法。综合考虑云的红外辐射的各个因素,建立了较为完善的云的红外辐射模型,引入光学厚度经验计算公式,并根据光学厚度针对中波和长波红外分别计算了云的发射率、反射率和透过率,进而得到云的红外辐射亮度分布。利用该计算方法,计算了中波和长波红外云的辐射亮度数值,计算结果表明：随着光学厚度增大,云的发射率和反射率增大,探测器接收到的云红外辐射增强。比较发现,该计算结果与实测数据有较好的一致性,该计算模型可以为云背景的红外特性分析、探测及仿真提供参考数据。     

一维矩形刻槽相位栅的减反特性与结构优化

 为了得到一种结构简单、便于制作的可应用于可见光波段的减反射膜,利用等效介质理论研究了表面具有矩形刻槽周期分布形式的介质膜的减反射特性,比较了4种不同基底材料的减反特性,选用聚甲基丙烯酸甲酯（PMMA）作为基底分析了一维单层矩形光栅结构的减反射膜的占空比、蚀刻深度、入射波长和入射角度对减反射特性的影响;给出了可见光波段的减反射膜的结构设计参数。研究结果表明：当入射角小于30°时,可见光中的短波段（0.4 μm～0.55 μm）反射率低于2%;当入射角小于10°时,该减反射膜可以使0.4 μm～0.8 μm可见光的反射率低于2%。     

多视点与深度视频编码技术研究综述

多视点与深度视频(MVD)可以有效表示自由视点视频,减少了需传输视点的个数,该表达形式正受到越来越多的关注,如何对MVD进行高效编码尤为重要.介绍了自由视点视频的发展现状及国内外研究概况,详细讨论了深度图像的高效编码技术及多视点与深度联合编码技术,并对多视点与深度视频编码技术进行了总结及展望.     

生长条件对InGaN/GaN多量子阱表面v型缺陷的影响

我们研究了生长温度、TMIn/TEGa和Ⅴ/Ⅲ比对 InGaN/GaN多量子阱表面v型缺陷的影响。当TMIn的流量从180sccm增加到200sccm,v型缺陷的密度也从2.7210¹⁸/cm² 增加到了5.2410¹⁸ /cm², v型缺陷的深度和宽度也随着TMIn流量的增加而增加。当生长温度从748℃增加到758℃, v型缺陷的密度分别是2.0510⁸/cm², 2.7210⁸/cm² 和 4.2310⁸/cm²,V型缺陷的密度随着生长温度的增加而增加。当NH3的流量从5000sccm增加到8000sccm, v型缺陷的密度分别为 6.3410¹⁸/cm², 2.7210¹⁸/cm², 4.1310¹⁸/cm²。我们在753℃, TMIn 流量为180sccm, NH3 流量为6600sccm时,得到了晶体质量最好的InGaN/GaN 多量子阱,表面平整,v型缺陷的密度也比较少。V型缺陷的深度从10nm到30nm,宽度从100nm到200nm,为了抑制v型缺陷对GaN基LEDs反向电流(IR)和静电放电 (ESD) 的影响,我们需要生长更厚的p-GaN来填充这些v型缺陷。     

一种特殊阶梯板制作工艺技术的开发

近年来,随着PCB的迅猛发展,PCB的设计也日新月异。对于阶梯板的制作,目前业界通常是采用low-flow PP压合+控深铣开盖工艺或内层开槽填充硅胶等缓冲材料的工艺生产。介绍了一种采用机械控深铣+CO2激光工艺的特殊阶梯板制作方法。该工艺可缓解常规方法对层压控制的特别要求,而且在运作流程上也得到了一定简化,拓展了常规方法所无法实现的特殊订单制作。     

Error analysis on dihedral angle of corner-cube reflectors in Fourier transform spectrometer北大核心CSCD

Fourier transform spectrometer is an important spectral analysis instrument. To research the influence of the dihedral angle error of corner-cube reflectors on interference quality of oscillating Fourier transform spectrometer, the theoretical analysis and computer simulation were carried out. According to the oscillating Fourier transform spectrometer model, the mathematical expressions of the interference intensity and modulation depth with dihedral angle error were deduced. The tolerance of dihedral angle was determined by the modulation depth criterion. The optical design software Zemax was used to establish the model for simulation and verify the results of theoretical derivation. According to the modulation depth criterion, the tolerance of dihedral angle obtained by the theoretical model is 2.52″, and that obtained by the Zemax simulation is 2.38″. The error is 0.14″, which is acceptable. The analysis results show that the established theoretical model is reasonable, which has certain reference value for the design and installation of oscillating Fourier transform spectrometers. © 2022 Editorial office of Journal of Applied Optics. All rights reserved.