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961.
962.
The macroscopic dynamics of a kinetic equation involving a model wave-particle collision operator of plasma physics is investigated.
The Chapman-Enskog asymptotics is first considered in the framework of a hydrodynamic scaling. The obtained macroscopic model
still involves a kinetic variable, the particle energy in the rest frame of the fluid, but shares similarities with the compressible
Navier-Stokes equation of gas dynamics. Then a diffusive scaling is examined under the hypothesis of small perturbations of
a global equilibrium. In this case, the macroscopic model couples the usual incompressible Navier-Stokes with a diffusion
equation for the energy distribution function of the particles, constrained by an extended version of the Boussinesq relation.
In both cases, the effect of a Lorentz force term is developed, in the perspective of plasma physical modelling.
Received June 16, 1997 相似文献
963.
Cobalt‐Catalyzed Allylation of Heterobicyclic Alkenes: Ligand‐Induced Divergent Reactivities
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Yuan Huang Chao Ma Yi Xin Lee Rui‐Zhi Huang Prof. Yu Zhao 《Angewandte Chemie (International ed. in English)》2015,54(46):13696-13700
The allylation of heterobicyclic alkenes is presented for the first time. By using an inexpensive cobalt salt as the catalyst and easy‐to‐handle potassium allyltrifluoroborate as the reagent, an unprecedented formal hydroallylation of the bicyclic alkenes is realized in high efficiency. When a chiral cobalt/bis(phosphine) complex is used instead, the alternative ring‐opening products can be obtained in high yield and excellent enantioselectivity. 相似文献
964.
Carotenoids are essential pigments in natural photosynthesis. They absorb in the blue–green region of the solar spectrum and transfer the absorbed energy to (bacterio-)chlorophylls, and so expand the wavelength range of light that is able to drive photosynthesis. This process is an example of singlet–singlet energy transfer and so carotenoids serve to enhance the overall efficiency of photosynthetic light reactions. Carotenoids also act to protect photosynthetic organisms from the harmful effects of excess exposure to light. In this case, triplet–triplet energy transfer from (bacterio-)chlorophyll to carotenoid plays a key role in this photoprotective reaction. In the light-harvesting pigment–protein complexes from purple photosynthetic bacteria and chlorophytes, carotenoids have an additional role, namely the structural stabilization of those complexes. In this article we review what is currently known about how carotenoids discharge these functions. The molecular architecture of photosynthetic systems will be outlined to provide a basis from which to describe the photochemistry of carotenoids, which underlies most of their important functions in photosynthesis. Then, the possibility to utilize the functions of carotenoids in artificial photosynthetic light-harvesting systems will be discussed. Some examples of the model systems are introduced. 相似文献
965.
Ana M. Geer Ángel L. Serrano Prof. Bas de Bruin Prof. Miguel A. Ciriano Dr. Cristina Tejel 《Angewandte Chemie (International ed. in English)》2015,54(2):472-475
Complexes with terminal phosphanido (M? PR2) functionalities are believed to be crucial intermediates in new catalytic processes involving the formation of P? P and P? C bonds. We showcase here the isolation and characterization of mononuclear phosphanide rhodium complexes ([RhTp(H)(PR2)L]) that result from the oxidative addition of secondary phosphanes, a reaction that was also explored computationally. These compounds are active catalysts for the dehydrocoupling of PHPh2 to Ph2P? PPh2. The hydrophosphination of dimethyl maleate and the unactivated olefin ethylene is also reported. Reliable evidence for the prominent role of mononuclear phosphanido rhodium species in these reactions is also provided. 相似文献
966.
Back Cover: Cofactor‐Free Light‐Driven Whole‐Cell Cytochrome P450 Catalysis (Angew. Chem. Int. Ed. 3/2015)
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967.
Cytochrome P450s are a superfamily of heme monooxygenases which catalyze a wide range of biochemical reactions. The reactions involve the introduction of an oxygen atom into an inactivated carbon of a compound which is essential to produce an intermediate of a hydroxylated product. The diversity of chemical reactions catalyzed by cytochrome P450s has led to their increased demand in numerous industrial and biotechnology applications. A recent study showed that a gene sequence encoding a CYP was found in the genome of Bacillus lehensis G1, and this gene shared structural similarity with the bacterial vitamin D hydroxylase (Vdh) from Pseudonocardia autotrophica. The objectives of present study was to mine, for a novel CYP from a new isolate B. lehensis G1 alkaliphile and determine the biological properties and functionalities of CYP in this bacterium. Our study employed the usage of computational methods to search for the novel CYP from CYP structural databases to identify the conserved pattern, functional domain and sequence properties of the uncharacterized CYP from B. lehensis G1. A computational homology model of the protein’s structure was generated and a docking analysis was performed to provide useful structural knowledge on the enzyme’s possible substrate and their interaction. Sequence analysis indicated that the newly identified CYP, termed CYP107CB2, contained the fingerprint heme binding sequence motif FxxGxxxCxG at position 336-345 as well as other highly conserved motifs characteristic of cytochrome P450 proteins. Using docking studies, we identified Ser-79, Leu-81, Val-231, Val-279, Val-383, Ala-232, Thr-236 and Thr-283 as important active site residues capable of stabilizing interactions with several potential substrates, including vitamin D3, 25-hydroxyvitamin D3 and 1α-hydroxyvitamin D3, in which all substrates docked proximally to the enzyme’s heme center. Biochemical analysis indicated that CYP107CB2 is a biologically active protein to produce 1α,25-dihydroxyvitamin D3 from 1α-hydroxyvitamin D3. Based on these results, we conclude that the novel CYP107CB2 identified from B. lehensis G1 is a putative vitamin D hydroxylase which is possibly capable of catalyzing the bioconversion of parental vitamin D3 to calcitriol, or related metabolic products. 相似文献
968.
Rücktitelbild: Cofactor‐Free Light‐Driven Whole‐Cell Cytochrome P450 Catalysis (Angew. Chem. 3/2015)
969.
Electrodeposition and characterization of Zn–Sn alloy coatings from a deep eutectic solvent based on choline chloride for corrosion protection
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S. Fashu C. D. Gu J. L. Zhang W. Q. Bai X. L. Wang J. P. Tu 《Surface and interface analysis : SIA》2015,47(3):403-412
With the aim of obtaining high corrosion resistant Zn–Sn alloy coatings from an ionic liquid, the effects of electrodeposition potential and electrolyte composition on the electrodeposition behavior, film composition, morphology and corrosion performance were investigated. Cyclic voltammograms indicate that Zn and Sn were co‐deposited at distinct reduction potentials as pure Zn and Sn elements. In addition, the phase composition analysis also showed that the obtained Zn–Sn alloy deposits (8 wt.%–45 wt.% Zn) consist of a two‐phase mechanical mixture of small aggregates of Zn and Sn metals. The Zn content of the alloy significantly increases as the electrodeposition potential and electrolyte Zn (II)/Sn (II) ratio increase. The corrosion performance study of the obtained Zn–Sn coatings showed that they have a passivation behavior and their corrosion resistance increases as the alloy‐Sn content increases. To improve their morphological properties, ethylene diamine tetraacetic acid additive was introduced into the electrolyte and greatly improved the morphology and corrosion resistance of the deposits. For the first time, it was shown that high corrosion resistance Zn–Sn coatings can be obtained from ionic liquids. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
970.
QM/MM modeling of the hydroxylation of the androstenedione substrate catalyzed by cytochrome P450 aromatase (CYP19A1)
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Ignacio Viciano Raquel Castillo Sergio Martí 《Journal of computational chemistry》2015,36(23):1736-1747
CYP19A1 aromatase is a member of the Cytochrome P450 family of hemeproteins, and is the enzyme responsible for the final step of the androgens conversion into the corresponding estrogens, via a three‐step oxidative process. For this reason, the inhibition of this enzyme plays an important role in the treatment of hormone‐dependent breast cancer. The first catalytic subcycle, corresponding to the hydroxilation of androstenedione, has been proposed to occur through a first hydrogen abstraction and a subsequent oxygen rebound step. In present work, we have studied the mechanism of the first catalytic subcycle by means of hybrid quantum mechanics/molecular mechanics methods. The inclusion of the protein flexibility has been achieved by means of Free Energy Perturbation techniques, giving rise to a free energy of activation for the hydrogen abstraction step of 13.5 kcal/mol. The subsequent oxygen rebound step, characterized by a small free energy barrier (1.5 kcal/mol), leads to the hydroxylated products through a highly exergonic reaction. In addition, an analysis of the primary deuterium kinetic isotopic effects, calculated for the hydrogen abstraction step, reveals values (~10) overpassing the semiclassical limit for the C? H, indicating the presence of a substantial tunnel effect. Finally, a decomposition analysis of the interaction energy for the substrate and cofactor in the active site is also discussed. According to our results, the role of the enzymatic environment consists of a transition state stabilization by means of dispersive and polarization effects. © 2015 Wiley Periodicals, Inc. 相似文献