Classifying G-protein coupled receptors with bagging classification tree

G-protein coupled receptors (GPCRs) play a key role in different biological processes, such as regulation of growth, death and metabolism of cells. They are major therapeutic targets of numerous prescribed drugs. However, the ligand specificity of many receptors is unknown and there is little structural information available. Bioinformatics may offer one approach to bridge the gap between sequence data and functional knowledge of a receptor. In this paper, we use a bagging classification tree algorithm to predict the type of the receptor based on its amino acid composition. The prediction is performed for GPCR at the sub-family and sub-sub-family level. In a cross-validation test, we achieved an overall predictive accuracy of 91.1% for GPCR sub-family classification, and 82.4% for sub-sub-family classification. These results demonstrate the applicability of this relative simple method and its potential for improving prediction accuracy.     

Factorization of Markov Chains

Existence of following factorization is proved:

深沪股市收益率分布特征的统计分析

本文通过对深沪两地股票市场的股指收益率数据进行分析,发现两地股票收益率分布均呈现"尖峰厚尾"反正态特征,本文通过引入Laplace分布代替过去人们常用的正态分布去刻画收益率分布,结果显示Laplace分布比正态分布拟合效率有了明显的提高。     

On the Almost Intersections of Transient Brownian Motions

Let {B ₁ ^d (t)} and {B ^d ₂(t)} be independent Brownian motions in R ^d starting from 0 and nx respectively, and let w ^d _i (a,b) ={xR ^d : B ^d _i (t)=x for some t(a,b)}, i=1,2. Asymptotic expressions as n for the probability of dist(w ^d ₁(n ² t ₁, n ² t ₂), w ₂ ^d (0,n ² t ₃))1 with d4, respectively for the probability of dist(w ₁ ⁴(n ² t ₁,n ² t ₂),w ₂ ⁴(0,n ² t ₃))1 are obtained. As an application, an improvement of a result due to M. Aizenman concerning the intersections of Wiener sausages in R ⁴ is presented.     

Explicit Expressions for the Ruin Probabilities of Erlang Risk Processes with Pareto Individual Claim Distributions

In this paper we first consider a risk process in which claim inter-arrival times and the time untilthe first claim have an Erlang (2) distribution.An explicit solution is derived for the probability of ultimateruin,given an initial reserve of u when the claim size follows a Pareto distribution.Follow Ramsay,Laplacetransforms and exponential integrals are used to derive the solution,which involves a single integral of realvalued functions along the positive real line,and the integrand is not of an oscillating kind.Then we showthat the ultimate ruin probability can be expressed as the sum of expected values of functions of two differentGamma random variables.Finally,the results are extended to the Erlang(n) case.Numerical examples aregiven to illustrate the main results.     

Two-Parametric Compound Binomial Approximations

We consider two-parametric compound binomial approximation of the generalized Poisson binomial distribution. We show that the accuracy of approximation essentially depends on the symmetry or shifting of distributions and construct asymptotic expansions. For the proofs, we combine the properties of norms with the results for convolutions of symmetric and shifted distributions. In the lattice case, we use the characteristic function method. In the case of almost binomial approximation, we apply Steins method.__________Published in Lietuvos Matematikos Rinkinys, Vol. 44, No. 4, pp. 443–466, October–December, 2004.     

The Halász Inequality for Additive Function of Rational Argument

We obtain an upper bound for the quantity . Here I is an interval, is the set of rational numbers q=m/n I such that nx, and f(q) is an arbitrary real-valued additive function of rational argument. The interval I and function f may depend on x3.     

Infinitesimal Liouville Distributions for Teichmuller space

We consider an arbitrary Riemann surface X, possibly of infinitehyperbolic area. The Liouville measure of the hyperbolic metricdefines a measure on the space of geodesics of the universal covering of X. As we vary the Riemann surface structure,this gives an embedding from the Teichmuller space of X intothe Fréchet space of Hölder distributions on G. We show that the embedding is continuouslydifferentiable. In particular, we obtain an explicit integralrepresentation of the tangent map. 2000 Mathematics SubjectClassification 30F60, 32G15 (primary), 46F99 (secondary).     

A complete description of Golay pairs for lengths up to 100

In his 1961 paper, Marcel Golay showed how the search for pairs of binary sequences of length with complementary autocorrelation is at worst a problem. Andres, in his 1977 master's thesis, developed an algorithm which reduced this to a search and investigated lengths up to 58 for existence of pairs. In this paper, we describe refinements to this algorithm, enabling a search at length 82. We find no new pairs at the outstanding lengths 74 and 82. In extending the theory of composition, we are able to obtain a closed formula for the number of pairs of length generated by a primitive pair of length . Combining this with the results of searches at all allowable lengths up to 100, we identify five primitive pairs. All others pairs of lengths less than 100 may be derived using the methods outlined.

     

Tail Calculus with Remainder,Applications to Tail Expansions for Infinite Order Moving Averages,Randomly Stopped Sums,and Related Topics

We derive asymptotic expansions for tails of infinite weighted convolutions of some heavy-tailed distributions. Applications are given to tail expansion of the marginal distribution of ARMA processes, randomly stopped sums, as well as limiting waiting time distribution. AMS 2000 Subject Classifications. Primary—62E99, Secondary—41A60, 44A35, 60G50, 60K25