空穴阻挡层对有机发光二极管寿命的影响

为研究空穴阻挡层对有机发光二极管寿命的影响,制备了含有空穴阻挡层的典型双层结构有机发光二极管,其中八羟基喹啉铝(Alq3)为发光层和电子传输层,BCP 为空穴阻挡层.器件的寿命随着发光层的厚度减小而降低,实验结果表明积累在发光层的空穴和激子可能是影响器件寿命的主要原因之一.     

Molecular Docking of SP40 Peptide towards Cellular Receptors for Enterovirus 71 (EV-A71)

Enterovirus 71 (EV-A71) is one of the predominant etiological agents of hand, foot and mouth disease (HMFD), which can cause severe central nervous system infections in young children. There is no clinically approved vaccine or antiviral agent against HFMD. The SP40 peptide, derived from the VP1 capsid of EV-A71, was reported to be a promising antiviral peptide that targeted the host receptor(s) involved in viral attachment or entry. So far, the mechanism of action of SP40 peptide is unknown. In this study, interactions between ten reported cell receptors of EV-A71 and the antiviral SP40 peptide were evaluated through molecular docking simulations, followed by in vitro receptor blocking with specific antibodies. The preferable binding region of each receptor to SP40 was predicted by global docking using HPEPDOCK and the cell receptor-SP40 peptide complexes were refined using FlexPepDock. Local molecular docking using GOLD (Genetic Optimization for Ligand Docking) showed that the SP40 peptide had the highest binding score to nucleolin followed by annexin A2, SCARB2 and human tryptophanyl-tRNA synthetase. The average GoldScore for 5 top-scoring models of human cyclophilin, fibronectin, human galectin, DC-SIGN and vimentin were almost similar. Analysis of the nucleolin-SP40 peptide complex showed that SP40 peptide binds to the RNA binding domains (RBDs) of nucleolin. Furthermore, receptor blocking by specific monoclonal antibody was performed for seven cell receptors of EV-A71 and the results showed that the blocking of nucleolin by anti-nucleolin alone conferred a 93% reduction in viral infectivity. Maximum viral inhibition (99.5%) occurred when SCARB2 was concurrently blocked with anti-SCARB2 and the SP40 peptide. This is the first report to reveal the mechanism of action of SP40 peptide in silico through molecular docking analysis. This study provides information on the possible binding site of SP40 peptide to EV-A71 cellular receptors. Such information could be useful to further validate the interaction of the SP40 peptide with nucleolin by site-directed mutagenesis of the nucleolin binding site.     

SDMA系统DL方案阻塞率的仿真

多址接入技术是无线通信系统设计的一个重要因素,未来无线通信系统将广泛采用空分多址（SDMA）接入技术来提高系统容量。比如在频分复用（FDMA）,时分复用（TDMA）,码分复用（CDMA）。介绍了Erlang-B分布这一典型的业务分配模型,并考虑了SDMA系统中DL信道分配机制,给出了理论推导,并采用一般的排队论模型对数字蜂窝移动通信系统中SDMA技术进行仿真。仿真结果表明：采用DL信道分配机制以后,用户可以在同一时间共享同一信道。     

具有积累层沟道的槽栅IGBT结构

提出了一种具有积累层沟道的槽栅IGBT结构。仿真结果表明：在阻断电压为1200V,集电极电流密度为100 A/cm2,温度分别为300K和400K下的情况下,积累层沟道槽栅IGBT的正向压降分别为1.5V 和2V而常规槽栅IGBT分别为1.7V和2.4V。新结构比常规槽栅IGBT具有更低的开态压降和更大的正向安全工作区。文中同时分析了积累层沟道槽栅IGBT的阻断特性和关断特性。     

Novel Efficient De-blocking Method for Highly Compressed Images

Due to coarse quantization, block-based discrete cosine transform（BDCT） compression methods usually suffer from visible blocking artifacts at the block boundaries. A novel efficient deblocking method in DCT domain is proposed. A specific criterion for edge detection is given, one-dimensional DCT is applied on each row of the adjacent blocks and the shifted block in smooth region, and the transform coefficients of the shifted block are modified by weighting the average of three coefficients of the block. Mean square difference of slope criterion is used to judge the efficiency of the proposed algorithm. Simulation results show that the new method not only obtains satisfactory image quality, but also maintains high frequency information.     

基于光森林的弹性光网络能效组播路由频谱分配策略

在弹性光网络中,光树传输组播可以节省链路代价,但较长的光树需要选择更低的调制等级,消耗更多的频谱资源和发射机功耗.提出一种基于遗传算法的光森林组播和光树重配置(GAMF-TR)优化组播的能效路由、调制格式和频谱分配(RMSA)策略.GAMF-TR策略设计染色体编码表示光森林的组播目的节点划分和光路径组合,通过染色体的基因位概率交叉和变异得到更多的光森林RMSA策略,设计了一个频谱分配效率和发射机功耗折中的适应度函数选择能效最高的光森林RMSA策略,并设计在网络资源充足时将组播从光森林重配置到光树传输,进一步减少发射机功耗的消耗.仿真结果表明:提出的GAMF-TR策略获得了组播的最低带宽阻塞率和最高能效性能.     

去块效应方法的研究

主要陈述了视频压缩中的去块效应方法,着重介绍了作为后处理模块的去块效应算法,主要包括空域滤波、凸集映射迭代、基于小波变换的频域滤波以及最大后验概率等方法,最后从图像质量、PSNR性能和复杂度等方面分析了算法的优缺点以及适用场合.     

A new static induction thyristor with high forward blocking voltage and excellent switching performances

A new static induction thyristor (SITH) with a strip anode region and p~- buffer layer structure (SAP-B) has been successfully designed and fabricated. This structure is composed of a p~- buffer layer and lightly doped n~-regions embedded in the p~+-emitter. Compared with the conventional structure of a buried-gate with a diffused source region (DSR buried-gate), besides the simple fabrication process, the forward blocking voltage of this SITH has been increased to 1600 V from the previous value of 1000 V, the blocking gain increased from 40 to 70, and the turn-off time decreased from 0.8 to 0.4μs.     

弹性光网络中基于安全性感知的差异化虚拟光网络的映射策略

针对虚拟环境下底层网络中光纤的概率性故障,传统的100%保护至少需要配置一条保护路径,造成资源冗余度高和虚拟网络请求接受率低的问题,该文提出一种基于安全性感知的差异化虚拟光网络的映射(SA-DVNM)策略,在链路发生故障时为差异化虚拟网络请求提供安全保证。在SA-DVNM策略中,设计了一个综合考虑物理节点对之间跳数和相邻带宽大小的节点权重式避免链路映射过长,并提出路径频谱资源使用均衡的链路映射机制,最小化瓶颈链路的数量。当单路径传输失败时,SA-DVNM策略设计允许路径分割的资源分配机制,为保障时延敏感业务的安全性,SA-DVNM策略在路由选择中设计了基于时延差优化的多路径路由频谱分配方法。仿真结果表明该文所提策略在概率故障环境中能够降低带宽阻塞率,提高频谱资源利用率和虚拟光网络接受率。

     

Synthesis of Some Novel 1,4‐Phenylene‐bis‐thiazolyl Derivatives and Their Anti‐hypertensive α‐blocking Activity Screening

A series of novel 1,4‐phenylene‐bis‐thiazolyl derivatives were synthesized and evaluated for their anti‐hypertensive activities as α‐blocking agents and some of them showed promising activities.