一种改进的小波基线校正方法的研究

通过对小波变换基线校正中最佳分解尺度方法的研究,提出了一种新的基于小波变换的最佳分解尺度确定方法,不但有效地提高了基线校正效果,而且具有简单、快速的优点.将该方法应用于血糖光谱数据预处理中进行基线校正,取得了较好的效果.通过人体口服葡萄糖耐量试验(OGTT)得到人体无创检测近红外光谱和对应血糖浓度值,然后采用该方法对上述光谱进行基线校正并建立多元回归模型,采用交互验证的方式对模型及基线校正的效果进行了评价.实验结果表明,血糖浓度预测值和参考值间的相关系数为0.75,预测均方根误差(RMSEP)为1.36 mmol/L,与原始光谱预测结果和其他小波分解尺度下的预测结果相比,RMSEP降低了将近39%,相关系数提高了0.64,预测精度得到较大幅度提高.     

鼻腔内低强度激光照射疗法的机理

鼻腔内低强度激光照射疗法(ILILT)是鼻腔内低强度激光照射在内科疾病方面的临床应用.ILILT由血液、经络和植物神经3条通路介导,至少其中一条通路的功能远离其功能内稳态.血液通路得到ILILT改善血管疾病患者的血脂和血液流变学指标的临床研究的直接证实.ILILT的经络介导假定得到针灸和ILILT临床疗效的比较研究的支持.ILILT的康复作用是通过促进长寿因子(烟酰胺腺嘌呤二核苷酸辅酶依赖的去乙酰化酶)水平的提高介导的.     

利用动脉血液的时变差分光谱实现血氧饱和度的测量

血氧饱和度的无创检测已在临床医学中得到广泛应用.目前的测量方法主要基于人手指的双波长光度分析原理,存在测量重复性差、检测速率低和误差大等缺陷,而且由于它完全忽略光散射的影响,理论上有不合理性.为了改进现有技术,分析了光散 射对手指组织吸光度的影响,并根据动脉血液在红外及近红外区域(600nm～1000nm)吸光度的时变特性,引入了时变差分光谱的概念;提出了利用时变差分光谱实现血氧饱和度测量的方法,并首次推导出包含光散射因子的血氧饱和度计算公式.与现有技术的对比表明,该测量方法具有测量准确、检测速率高、抗干扰性强和方便实现的特点,在理论上更严谨、更科学.     

Neimark-Sacker bifurcation of a semi-discrete hematopoiesis model

In this paper, we derive a semi-discrete system for a nonlinear model of blood cell production. The local stability of its fixed points is investigated by employing a key lemma from [23, 24]. It is shown that the system can undergo Neimark-Sacker bifurcation. By using the Center Manifold Theorem, bifurcation theory and normal form method, the conditions for the occurrence of Neimark-Sacker bifurcation and the stability of invariant closed curves bifurcated are also derived. The numerical simulations verify our theoretical analysis and exhibit more complex dynamics of this system.     

Application of Chitosan-Based Biomaterials for Blood Vessel Regeneration

Summary: Vascular diseases are the leading cause of morbidity and mortality in the western world. Autologous vessels remain the standard for coronary grafting and peripheral bypass surgery; however, their availability in patients can be limited. Therapeutic angiogenesis using growth factors, genes, or progenitor cells has been given considerable scientific attention over the last decade, but has not yet provided a definitive clinical benefit. Biomaterials could be developed to protect protein, DNA and cells against hostile conditions. Chitosan, a natural polymer of glucosamine and N-acetyl glucosamine, has been widely studied in tissue engineering due to its biocompatibility, biodegradability, and muco-adhesive and antimicrobial properties. Notably, the application of chitosan has been gaining attention in the vascular field due to its structural similarity to glycosaminoglycans, which are components of a tissue's extracellular matrix. In this review, chitosan-based materials, and their use in tissue engineered blood vessels, and as protein, gene and cell vectors for angiogenic therapy are discussed.     

A DLM/FD/IB Method for Simulating Cell/Cell and Cell/Particle Interaction in Microchannels

A spring model is used to simulate the skeleton structure of the red blood cell （RBC） membrane and to study the red blood cell （RBC） rheology in Poiseuille flow with an immersed boundary method. The lateral migration properties of many cells in Poiseuille flow have been investigated. The authors also combine the above methodology with a distributed Lagrange multiplier/fictitious domain method to simulate the interaction of cells and neutrally buoyant particles in a microchannel for studying the margination of particles.     

Dose in Skeleton and Bone Marrow following Thorotrast Injection into Blood

The calculation of the dose rate and cumulative dose in the morrow-free skeleton and bone marrow of thorotrast patients presupposes the knowledge of both the translocation of thorium daughters to the skeleton, and the portion of ²³²Th that is localized in colloidal form in the bone marrow. Whereas in bon marrow ²²⁸Th is in equilibrium with ²³²Th up to only 20%, in marrow-free skeleton ²²⁸Th is present in excess to ²³²Th (average activity ratio 1·75), considering the measured activity ratios between ²³²Th and its daughters as well as the distribution of the colloid and the unclides of the thorium decay chain within the organism the dose rate and cumulative dose in bone marrow and marrow-free bone were calculated as function of the time of thorotrast burden and the amount of injected material.     

Dickenmeßgeräte für die Automatisierung von Kaltbandwalzwalzwerken

Nach einem kurzen Vergleich verschiedener Meßverfahren werden die speziellen Probleme beim Einsatz von Dickenmeßgeräten mit radioaktiven Nukliden in autoautomatischen Walzanlagen dargelegt. An Hand der Forderungen nach konstanter Empfindlichkeit, geringer Meßunsicherheit, Fernbedienbarkeit, leistungsstarker Ausgangsgröße und optimalem Zeitverhalten wird die Konzeption der Flächengewichtsmeßgerate VA-T-74 und VA-T-75 beschrieben. Die wichtigsten Daten werden mitgeteilt.     

Direct Radioimmunoassay of Proinsulin and Insulin in Human Plasma by Chromatographic Technique

Specific method for direct radioimmunoassay of IRP and IRI separately in human plasma has been described. The method is used for extraction of total insulin and separation of IRP from IRI by paper chromatography to be assayed separately. The separation of the two components are indentified and confirmed by column chromatography, paper chromatography and U.V. spectral analysis in comparison with the standard compounds.

134 plasma samples of different cases were, investigated for determination of IRI, IRP and IRT, of which 39 normals, 16 normal obes, 21 juvinil diabetes, 18 adult oncet diabetes, 10 recent adult diabetes, 12 hypothroid and 18 bilharzial hepatosplenomegaly to evaluate the levels of the test in comparison with blood sugar concentration.