基于ARM的振动信号采集分析系统设计

主要介绍了基于s3c2410A ARM9微处理器的振动信号采集分析系统的设计方案,该系统主要由硬件和软件两部分组成,其中重点研究了基于Qt/E的图形界面的应用程序和AD Linux驱动的开发。此系统比传统的振动信号采集分析系统具有更好的实时性和性价比。     

开发Windows 9x下的电火花加工数控系统的关键技术

详细讨论了利用虚拟设备驱动程序技术开发Windows 9x下电火花加工数控系统的原理和方法，并给出了开发实例。     

宽波长宽角度消偏振分光镜设计

简要介绍K9玻璃棱镜中用金属介质膜系实现宽波长宽角度消偏振的设计 ,设计波长为 4 2 0～ 6 80nm ,空气中的入射角变化范围为± 8° ,膜系的透过率T和反射率R的平均偏离约为 2 .5 % ,S偏振分量和P偏振分量的平均偏离约为 1%。     

Electrochemical Immunoassay for Tumor Marker CA19-9 Detection Based on Self-Assembled Monolayer

A CA19-9 electrochemical immunosensor was constructed using a hybrid self-assembled membrane modified with a gold electrode and applied to detect real samples. Hybrid self-assembled membranes were selected for electrode modification and used to detect antigens. First, the pretreated working electrodes were placed in a 3-mercaptopropionic acid (MPA)/β-mercaptoethanol (ME) mixture for 24 h for self-assembly. The electrodes were then placed in an EDC/NHS mixture for 1 h. Layer modification was performed by stepwise dropwise addition of CA19-9 antibody, BSA, and antigen. Differential pulse voltammetry was used to characterize this immunosensor preparation process. The assembled electrochemical immunosensor enables linear detection in the concentration range of 0.05–500 U/mL of CA19-9, and the detection limit was calculated as 0.01 U/mL. The results of the specificity measurement test showed that the signal change of the interfering substance was much lower than the response value of the detected antigen, indicating that the sensor has good specificity and strong anti-interference ability. The repeatability test results showed that the relative standard deviations were less than 5%, showing good accuracy and precision. The CA19-9 electrochemical immunosensor was used for the actual sample detection, and the experimental results of the standard serum addition method showed that the RSD values of the test concentrations were all less than 10%. The recoveries were 102.4–115.0%, indicating that the assay has high precision, good accuracy, and high potential application value.     

In Silico Drug Repurposing of FDA-Approved Drugs Highlighting Promacta as a Potential Inhibitor of H7N9 Influenza Virus

Influenza virus infections continue to be a significant and recurrent public health problem. Although vaccine efficacy varies, regular immunisation is the most effective method for suppressing the influenza virus. Antiviral drugs are available for influenza, although two of the four FDA-approved antiviral treatments have resulted in significant drug resistance. Therefore, new treatments are being sought to reduce the burden of flu-related illness. The time-consuming development of treatments for new and re-emerging diseases such as influenza and the high failure rate are increasing concerns. In this context, we used an in silico-based drug repurposing method to repurpose FDA-approved drugs as potential therapies against the H7N9 virus. To find potential inhibitors, a total of 2568 drugs were screened. Promacta, tucatinib, and lurasidone were identified as promising hits in the DrugBank database. According to the calculations of MM-GBSA, tucatinib (−54.11 kcal/mol) and Promacta (−56.20 kcal/mol) occupied the active site of neuraminidase with a higher binding affinity than the standard drug peramivir (−49.09 kcal/mol). Molecular dynamics (MD) simulation studies showed that the C-α atom backbones of the complexes of tucatinib and Promacta neuraminidase were stable throughout the simulation period. According to ADME analysis, the hit compounds have a high gastrointestinal absorption (GI) and do not exhibit properties that allow them to cross the blood–brain barrier (BBB). According to the in silico toxicity prediction, Promacta is not cardiotoxic, while lurasidone and tucatinib show only weak inhibition. Therefore, we propose to test these compounds experimentally against the influenza H7N9 virus. The investigation and validation of these potential H7N9 inhibitors would be beneficial in order to bring these compounds into clinical settings.     

稀土元素Pr替位改性的高温CaBi_2Nb_2O_9压电陶瓷

采用普通陶瓷工艺制备了由稀土元素Pr替位改性的高温Ca1-xPrxBi2Nb2O9(x=0～0.100)无铅压电陶瓷,研究了Pr含量对CaBi2Nb2O9(CBNO)压电陶瓷介电及压电性能的影响。结果表明:Pr对Ca的替换明显提高了CBNO压电陶瓷的压电性能。其中,Pr含量x为0.050的Ca0.95Pr0.05Bi2Nb2O9压电陶瓷表现出最好的压电性能,其压电常数d33高达14pC/N,且在800℃以下表现出良好的温度稳定性。     

Heric逆变器驱动电路研究与设计

传统Heric逆变器各个桥臂采用相同的驱动电路,造成保护功能的重复,文章针对Heric逆变电路上下桥臂的导通状态,对逆变器上、下桥臂驱动电路的功能进行了划分,分别设计了上、下桥臂驱动电路,使其实现互补配合的保护功能,并针对驱动电路中光耦隔离芯片输出失真的问题,在光耦输入侧加入驱动增强电路。对驱动电路进行测试,实验结果表明该驱动电路可靠性较高,在占空比变化范围较宽时失真度小,逆变器输出波形较好。     

ANSYS在脉冲CO_2激光对K9玻璃损伤过程模拟中的应用研究

从脉冲CO2激光损伤K9玻璃有限元模型的建立和网格划分、脉冲激光的加载、设置初始条件和边界条件等几个方面,分析了基于ANSYS的脉冲CO2激光损伤K9玻璃模拟过程中的一些关键问题,建立了脉冲CO2激光损伤K9玻璃的有限元模型,对K9玻璃受到脉冲CO2激光辐照时的温度和应力分布进行了数值分析.     

Solid‐State Active Elements Based on Dyes and Prepared by a Sol‐Gel Method

A new method is suggested for producing the solgel matrices with the molecules of laser dyes introduced into them. The curves of tuning lasing in Rhodamine 6G, Rhodamine 4S, Rhodamine 101, and phenylamine 430 in these matrices are obtained. The total range of tuning is 550–650 nm at a pumping energy of 4 mJ. The halfwidth of the generation spectrum is independent of the pumping energy to 4 mJ and comprises 0.3 ± 0.1 nm. The main factors forming the generation spectrum are noted.