一种新的De Novo生物活性分子设计方法

由药效团进行虚拟活性结构生成与3D-QSAR模型相结合,筛选出有前途的结构多样性的化合物,并从中寻找活性先导化合物,是一种新的分子设计方法。采用这种方法对抗小麦赤霉病类含氟农药进行了研究,共生成了53个虚拟活性结构,通过3D-QSAR模型筛选出其中10个活性较高的结构,在活性最高的化合物基础上进行了结构修饰,得到了活性更高且毒性较低的理想化合物。研究结果表明这种方法能突破原模型化合物结构模式的局限,可以找到结构新颖的活性先导化合物,是一种非常有前途的分子设计方法,而且具有较高的筛选效率。     

主被动锁模Nd∶YLF激光器

在脉冲抽运主动锁模Nd∶YLF激光器中 ,用倍频晶体CLBO和双色镜构成的非线性镜取代输出镜 ,实现了主被动锁模 ,与纯主动锁模相比 ,脉冲宽度压缩了 8倍 ,获得了 15ps的锁模脉冲     

用可变形模板进行基于内容的图像分割算法

 本文提出一种采用可变形模板匹配技术进行基于内容的图像分割算法.通过预先计算出可变形模板沿着变形的正交曲线,并对模板曲线及正交曲线进行离散抽样,建立一基于正交曲线的二维(2-D)可变形模板,针对图像分割问题定义控制可变形模板进行变形的内、外部能量函数,本文采用遗传算法搜索能量函数最小的全局最优解.该新算法比传统的可变形模板匹配方法降低了搜索空间的维数,减少了算法对模板初始位置的敏感.对实际图像及模拟低信噪比图像处理的结果表明,新算法具有良好的分割精度及稳定性.     

基于MOCC的电流模式连续时间滤波器

本文利用多端输出电流传送器MOCC实现电流模式低通滤波器和通用滤波器。所提出的电路结构简单 ,所有无源元件均接地 ,便于CMOS工艺实现。     

主动网安全授权机制的设计

以可编程交换机方案＾「１」为基础,以主动网络的节点安全为出发点,设计了一种主动网安全授权机制。设计要点包括划资源对象,定义对象操作集,建立层次化授权与用户管理结构,实现权限分级与授仅自动委托以及利用加密、摘要与签名算法保证授权的正确性和守整性。     

多功能光学活性丁二醇衍生物的合成和结构

通过新的合成策略,以手性合成子3和具有生物活性的有机碱类化合物4为反应底物,利用Michael不对称加成反应,合成得到光学纯的5-(R)-［(1R,2S,5R)-(-)-氧基］-4-(R)-(杂环碱基)-2(5H)-呋喃酮(5). 加成物5通过还原反应得到了多功能光学活性的二醇类化合物6,产率为42%~82%,e.e.≥98%. 化合物6的化学结构得到了确认,其立体化学结构和绝对构型经X射线晶体学测定得到了确定.     

分子印迹技术在天然产物有效成分分离纯化中的应用

天然产物体系复杂,大分子和小分子、生命和非生命物质共存,多存在结构相近的异构体,且有效成分含量低,采用一般的分离方法富集难度较大。分子印迹技术是制备高选择性分离介质的有效技术手段,分子印迹聚合物(MIP)的选择性强,分离操作简单,在各种分离纯化中展现了良好的应用前景。本文对近年来分子印迹技术在天然产物活性组分(如生物碱、甾体、多元酚、黄酮等)的分离纯化中的应用进行了综述,并介绍了本课题组利用MIP从天然产物中分离纯化莽草酸等活性成分的研究进展。     

New Bioactive Ceramics Obtained by Heat Treatment of Modified Polymeric Precursors

Summary: The aim of this work was to obtain pseudowollastonite-based ceramics and to determine its bioactive features. The materials were obtained by new method, namely thermal treatment of ceramic active fillers-containing polysiloxane polymeric precursor. As active fillers, commercially available Ca(OH)₂ and silica nanopowders (SiO₂) were used. The phase composition of ceramic products were analysed by the means of Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction analysis (XRD). The microstructure of ceramic products were studied by scanning electron microscopy (SEM) with EDS point analysis. The bioactivity was determined in “in vitro” conditions, by immersing of ceramic samples in simulated body fluid (SBF). The results presented in this work indicate that heat treatment of active fillers-containing polysiloxane precursor is an alternative method for receiving of pseudowollastonite-containing materials. Such obtained samples demonstrate bioactivity in “in vitro” conditions.     

脉冲功率放大器相位测量方法

有源相控阵雷达对T／R组件相位一致性有严格的要求,脉冲信号相位的测试比较复杂,本文提出了三种微波脉冲功率放大器相位的测试方法。     

Distribution of active earth pressure of retaining wall with wall movement of rotation about top

Based on the Coulomb‘s theory that the earth pressure against the back of a retaining wall is due to the thrust exerted by the sliding wedge of soil from the back of the wall to a plane which passes through the bottom edge of the wall and has an inclination equal to the angle of O, the theoretical answers to the unit earth pressure, the resultant earth pressure and the point of application of the resultant earth pressure on a retaining wall were obtained for the wall movement mode of rotation about top. The comparisons were made among the formula presented here, the formula for the wall movement mode of translation, the Coulomb‘ s formula and some experimental observations. It is demonstrated that the magnitudes of the resultant earth pressures for the wall movement mode of rotation about top is equal to that determined by the formula for the wall movement mode of translation and the Coulomb‘s theory. But the distribution of the earth pressure and the points of application of the resultant earth pressures have significant difference.