Comparing chemical fingerprints of herbal medicines using modified window target-testing factor analysis

A chromatographic fingerprint of a herbal medicine is essentially its chromatographic spectrum: a characteristic representation of its chemical components, some of which are pharmacologically active. Since a wide variety of factors, such as the geographical location, the harvest season, and the part used can influence the chemical constituents (and therefore the pharmacological activity) of any particular herbal medicine and its products, these fingerprints provide a way to compare and contrast the compositions of different variants of the same herbal medicine. In particular, it is possible to ascertain whether particular components present in one herbal fingerprint are also present in another fingerprint. In this work we use a novel method—modified window target-testing factor analysis (MWTTFA), based on the use of target factor analysis (TFA), fixed-size moving window evolving factor analysis (FSMWEFA) and a Gaussian shape correction to the chromatographic profiles—to achieve this end. To demostrate the strategy, the fingerprints of samples from garlics produced in different geographical locations were compared, as well as the fingerprints of samples taken from above-ground and below-ground parts of Houttuynia cordata Thunb. The results from these comparisons clearly show that four chemical components present in Hunan common edible garlic are absent in Xingping base garlic, while seven components are present in Xingping base garlic but absent in Hunan common edible garlic. Also, eleven components are present in the sample from the above-ground part of Houttuynia cordata Thunb but not in the sample from the below-ground part, while seven components are present in the sample from the below-ground part of Houttuynia cordata Thunb that are not present in the sample from the above-ground part. These interesting conclusions should be very useful for future pharmacological and clinical research into these herbal medicines, and the novel MWTTFA technique can also be used for quality control purposes.     

Gas-Mediated Tumor Energy Remodeling for Sensitizing Mild Photothermal Therapy

The metabolic reprogramming of tumors requires high levels of adenosine triphosphate (ATP) to maintain therapeutic resistance, posing a major challenge for photothermal therapy (PTT). Although raising the temperature helps in tumor ablation, it frequently leads to severe side effects. Therefore, improving the therapeutic response and promoting healing are critical considerations in the development of PTT. Here, we proposed a gas-mediated energy remodeling strategy to improve mild PTT efficacy while minimizing side effects. In the proof-of-concept study, a Food and Drug Administration (FDA)-approved drug-based hydrogen sulfide (H₂S) donor was developed to provide a sustained supply of H₂S to tumor sites, serving as an adjuvant to PTT. This approach proved to be highly effective in disrupting the mitochondrial respiratory chain, inhibiting ATP generation, and reducing the overexpression of heat shock protein 90 (HSP90), which ultimately amplified the therapeutic outcome. With the ability to reverse tumor thermotolerance, this strategy delivered a greatly potent antitumor response, achieving complete tumor ablation in a single treatment while minimizing harm to healthy tissues. Thus, it holds great promise to be a universal solution for overcoming the limitations of PTT and may serve as a valuable paradigm for the future clinical translation of photothermal nanoagents.     

Online movie success in sequential markets: Determinants of video-on-demand film success in Korea

Despite the growing online movie market, attributes of digital films are inadequately studied. This study analyzes theatrical and post-theatrical determinants of film success on the video-on-demand (VOD) market of Korea through 226 films. Key results show that higher box office records and shorter holdback were found significant, while box office performance had a significant interaction with the impact of holdback on VOD performance. The importance of box office performance on online performance may be explained by quality signals, promotions, or “me too” behavior. This study provides implications for online movie distribution, in which theatrical performance remains critical in increasing performance across platforms.     

Optical Properties of Window Coatings

Window coating used for the building in recent years is described.Important design principles, practical coating materials, and attainable optical properties for research-type coatings are introduced.Discussion is carried out on the spectrally selective coatings, the electrochromic coatings, and the thermochromic coatings.     

基于Hanning Window设计FIR数字高通滤波器

基于实序列的傅里叶变换具有的特征,提出了一种研究线性相位FIR数字滤波器幅度函数的简洁方法。首先揭示了偶对称和奇对称的线性相位FIR数字滤波器幅度函数的特点;然后研究了矩形窗函数对线性相位理想数字低通滤波器幅频特性的影响,即时域加矩形窗,频域形成过渡带;最后介绍了利用窗函数法设计FIR数字滤波器时,对窗函数的要求,选择窗函数的依据及利用窗函数法设计FIR数字滤波器的步骤,并给出了基于Hanning Window来设计FIR数字高通滤波器的实例。     

DCS600在拉弯矫直机列调速系统中的应用与调试

本文简要叙述了拉弯矫直机控制原理与方法,详细阐述了其调试过程和方法。实践证明其系统参数镇定匹配,控制效果良好,系统工作稳定。     

基于模糊中值滤波的椒盐噪声去除方法

研究基于模糊中值滤波的椒盐噪声去除方法。通过比较图像各像素点的灰度值,定义基于图像梯度信息的各点被判别为噪声点的模糊隶属函数。利用此模糊隶属函数对中值滤波方法进行加权,得到了一种加权中值滤波器,可实现边缘处椒盐噪声的有效滤除。讨论这种模糊加权方法与其它先进滤波方法的结合途径,指出了其推广应用价值。最后利用数值实验验证本文方法的有效性,结果表明,相比于自适应中值滤波方法,本文方法得到的滤波图像在峰值信噪比及结构相似度方面均有明显提高。     

Road traffic noise - the relationship between noise exposure and noise annoyance in Norway

Exposure-effect relationships between the level of road traffic noise at the most exposed side of a dwelling's façade and the residents' reactions to road traffic noise have been estimated. The relationships are based on five Norwegian socio-acoustic studies featuring 18 study areas from two cities and a total of near 4000 respondents. The survey questionnaires distinguish between noise annoyance experienced right outside the apartment and when indoors. Exposure-effect relationships for all degrees of annoyance are estimated simultaneously from ordinal logit models. These predict road traffic noise annoyance when right outside the apartment and when indoors, respectively, as a function of the road traffic noise level outside the most exposed façade. Separate analyses indicate that Norwegians react stronger to road traffic noise than results from a recent compilation of socio-acoustic surveys would lead one to believe. People having inferior single glazing windows report higher indoor annoyance.     

ASP.NET之Web打印初探

Web打印是一种比较难以掌握但又应用很广并且非常实用的一种技术。现有的技术有自定义控件、使用IE直接打印等。而使用IE直接打印又可分为直接调用Window Print（ ）和使用WebBrowser控件等。着重讨论使用IE直接打印的方法。使用该方法有两个难点内容：一是如何控制只打印页面中需要的部分，忽略不需要打印的部分；二是如何设置打印预览、页面设置等功能。将进行初步的探讨。     

窗口吸收区结构超辐射发光二极管的优化设计与特性研究

本文从理论上对1.3μm InGaAsP/InP窗口吸收区结构超辐射发光二极管进行了优化设计.并在考虑增益饱和和热效应的条件下,用耦合速率方程模拟计算了该结构超辐射发光二极管的功率输出特性.分析研究了窗口区长、泵浦区长、有源层厚度和输出腔面反射率对其输出特性的影响.研究结果表明,由于窗口吸收区的有效散射和吸收,很好地抑制了F-P受激振荡,可用于实现高性能超辐射发光二极管.