An obstruction to the positivity of relative Yamabe invariants

For a supergroup , we describe an obstruction to the existence of positive scalar curvature metrics with minimal boundary condition on a compact n-dimensional -manifold W with nonempty boundary M, , in terms of the bordism class [M] in the Stolz obstruction group associated to [St2]. In par ticular, when W is a 5-dimensional spin manifold and the -invariant of a connected component of M is nonzero, we prove that W does not admit a positive scalar curvature metric with minimal boundary condition. Received: 4 July 2001; in final form: 5 February 2002 / Published online: 8 November 2002 RID="*" ID="*" Partially supported by the Grants-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, No. 11640070.     

多端口T/R组件的单通道噪声系数测试方法

多端口T/R组件输出端口的噪声由各个通道共同决定,要测试单独通道的噪声系数非常困难。提出了一种基于衰减器改变的多端口TR组件单通道噪声系数测试方法,消除了其他通道的噪声影响,实现了对单独通道噪声系数的测试。通过测试一个8通道T/R组件的各个通道噪声系数,与单独通道测试结果进行了对比,两种方法测试结果最大差异为0.08 dB,验证了该方法可以很准确地测量多端口网络的单通道噪声系数。     

一种基于TMS320C6416T的激光色域转换方法

为了快速完成荧光色域到激光色域的颜色转换,设计了以高性能的DSP芯片为核心处理器,结合现场可编程门阵列FPGA的实时数字图像处理平台.给出了三组不同波长激光的色域转换矩阵,在基于TMS320C6416T的图像处理平台上实现了两个系统的信号转换,并且利用多种加速算法,加快了处理速度.实验结果表明,本文的方法有效地扩展了激光电视的颜色区域,降低了图像的饱和度.     

Delivery Techniques for Enhancing CAR T Cell Therapy against Solid Tumors

Chimeric antigen receptor (CAR) T cells exhibit promising results for cancer immunotherapy. However, the clinical success is still restricted to certain types of blood cancers, while in solid tumors the clinical activity is modest and potential toxicities remain a concern. There are various barriers that prevent CAR T cells from combating solid tumors. Therefore, distinct strategies have been explored to augment CAR T cell proliferative capacity, persistence, and effector function. Altering the tumor microenvironment, and in particular its physiochemical properties and immunosuppressive milieu, is of great significance to facilitate CAR T cell therapy. In this article, emerging strategies implemented to overcome the barriers of CAR T cell therapy in solid tumors are reviewed. Enhancing infiltration, activation, and persistence of CAR T cells has been addressed in several preclinical models. The future development of this field to promote innovation and clinical translation is also discussed.     

Oxygen-Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors

Solid tumors are protected from antitumor immune responses due to their hypoxic microenvironments. Weakening hypoxia-driven immunosuppression by hyperoxic breathing of 60% oxygen has shown to be effective in unleashing antitumor immune cells against solid tumors. However, efficacy of systemic oxygenation is limited against solid tumors outside of lungs and has been associated with unwanted side effects. As a result, it is essential to develop targeted oxygenation alternatives to weaken tumor hypoxia as novel approaches to restore immune responses against cancer. Herein, injectable oxygen-generating cryogels (O₂-cryogels) to reverse tumor-induced hypoxia are reported. These macroporous biomaterials are designed to locally deliver oxygen, inhibit the expression of hypoxia-inducible genes in hypoxic melanoma cells, and reduce the accumulation of immunosuppressive extracellular adenosine. The data show that O₂-cryogels enhance T cell-mediated secretion of cytotoxic proteins, restoring the killing ability of tumor-specific cytotoxic T lymphocytes, both in vitro and in vivo. In summary, O₂-cryogels provide a unique and safe platform to supply oxygen as a coadjuvant in hypoxic tumors and have the potential to improve cancer immunotherapies.     

直拉单晶炉减薄型加热器的数值模拟与实验分析

在直拉单晶炉中使用一种减薄型加热器替代原加热器,改变了单晶炉的热场温度分布。通过有限元模拟分析软件对减薄型加热器进行模拟分析,模拟结果指出减薄型加热器对提升单晶拉速、降低单晶炉功耗具有促进作用。通过对比两种加热器装料量,并进行单晶生长对比实验,实验指出,减薄型加热器在引晶、等径、收尾阶段均降低了功耗,提升了拉速。最后,数据分析指出减薄型加热器的经济性比原加热器有一定提升。     

弱闭T(N)-模的预零化子的等距映射

本文刻划了弱闭T(N)-模的预零化子间的等距映射.设u,W分别为由左连续序同态N→~N和N→~N所确定的弱闭T(N)-模, u(?),W(?)分别为u,W的预零化子,Φ为由u(?)到W(?)上的线性等距映射.若(0)*=(0)#=(0),dim(0)+≠1且min{dim(H(?)~H),dim(He(?)^H)}≥2,则存在酉算子Ui,Vi(i=1,2),使得Φ(A)=U1AV*1或Φ(A)=U2A*V2*.     

基于LTCC 厚薄膜混合基板的Ka 波段T/ R 组件封装技术

收发组件的集成封装技术是毫米波二维有源相控阵领域应用研究的重点和难点。文中采用基于低温共烧陶瓷厚薄膜混合基板制造工艺技术,同时结合先进的微组装工艺,实现了Ka 波段八单元组件的高精度、高密度及气密封装;给出了收发组件的封装模型,通过仿真与实测对比着重分析了垂直互联、功率分配/ 合成网路及通道隔离的提升等关键技术,并测试了无源组件的微波性能。结果表明:该集成封装技术能够满足二维毫米波相控阵天线对T/ R 组件小型轻量化和高组装密度的技术要求。     

基于MODBUS协议的触摸屏与MCU通信实例设计

为了提高陆轨两用电动汽车的可操控性,在MODBUS协议的基础上,设计实现以单片机为例的MCU与步科触摸屏MT4523T通讯的人机交互系统,并给出了设计方法与部分软件及其流程图.通过实际验证,该系统稳定可靠,能够简便地控制电动汽车的运行与换轨动作.在一定程度上为触摸屏与带串行接口的其他MCU间的通讯提供了参考.     

宽带波导魔T的设计

介绍了一种宽带波导魔T的设计,并使用三维电磁仿真软件对其进行仿真计算。本设计中波导魔T的带宽达到了一个倍频以上,使其有了更广的使用范围。