基于马尔可夫决策的理性秘密共享方案

基于马尔可夫决策理论研究理性密码共享系统模型和秘密重构方法。首先利用马尔可夫决策方法,提出适合于理性秘密共享的系统模型,该模型包括参与者集合、状态集合、风险偏好函数、状态转移函数、回报函数等。在模型中,引入秘密重构中的参与者的风险偏好函数刻画秘密共享模型的状态集合和状态转移函数。其次,基于所提出的系统模型构造相应的理性秘密共享方案,基于马尔可夫策略解决各理性参与者在秘密共享方案中的秘密重构问题。最后对方案进行理论分析证明,给出理性秘密重构方案中折扣因子、回报函数、参与者风险偏好函数间的函数关系,其结果表明所提系统模型方法的合理性和有效性。     

考虑恶意节点的CRN合作频谱感知方法

基于带有恶意节点的更为实际的频谱感知环境,研究了基于合作感知的频谱共享网络模型,次级用户将会根据合作感知结果动态地调整其发射功率。为了防止恶意节点对感知系统的感知性能造成严重影响,研究了如何进行合作感知以提高感知性能。在一定的检测概率和相关功率约束下,建立了一个以最大化次级网络的吞吐量为目标函数的优化问题。仿真实验首先突出说明了恶意节点数目对频谱感知影响重大,同时还表明无论是否存在恶意节点,提出的算法均可有效地计算出最优的感知时间和发射功率,且在降低最大干扰功率限制和最大发射功率限制时,网络的吞吐量是增大的。     

车联网中基于联盟合作博弈的带宽分享策略

近几年来,车联网领域快速发展并引起广泛关注.在此背景下提出了一种混合Wi-Fi、WiMAX和3G/LTE的网络架构,在这种架构下,车辆可以根据自身的情况选择合适的方式接入网络.网络带宽分享采用基于联盟合作博弈的方式,车辆可以选择加入或离开合作联盟来最大化自身收益.模型从理论上证明了通过车辆间的效用分配与博弈合作,最终将形成一个纳什稳定的联盟划分并能适应车辆的动态变化.仿真结果表明,模型的算法性能接近于最优联盟分配.     

Effects of Divalent Metal Ions on the Chaperone Activity and Structure of Rat Lens H18G Mutant αB‐Crystallin

αB‐crystalin, a small heat shock protein and a component of α‐crystalin, is a molecular chaperone playing an important role in preventing the formation of cataracts. It has been reported that His18 is an important site for Cu²⁺ to bind with to form a stable metal complex and thus to enhance this chaperone‐like activity of human αB‐crystalin. In this work, we used site‐directed mutagenesis to clone and express H18G rat lens αB‐crystalin in order to investigate the role of His18 in chaperoning activity. We found that 1 mM of Cu²⁺, or Zn²⁺, rather than Mg²⁺, significantly enhanced the chaperone‐like activity of wild type αB‐crystalin. Whereas, it is Zn²⁺ and Mg²⁺, not Cu²⁺, that significantly reduced this activity of H18G αB‐crystalin. In the absence of cation, H18G showed better activity compared to the wild type αB‐crystalin. ANS fluorescence measurement showed there was no linear relationship between chaperone‐like activity and surface hydrophobicity, indicating that surface hydrophobicity is not a prerequisite for chaperone‐like activity. An HPLC size‐exclusion chromatography study showed that in the presence of metal ions, wild type αB‐crystalin tended to aggregate via dissociation and re‐association into a high molecular aggregate with a molecular weight higher than 1400 kDa and then precipitated, suggesting that the presence of metal ions is a factor leading to the formation of cataracts. Both the near and far UV‐CD spectra suggested that the wild type αB‐crystalin reflected more β‐sheet structural characteristics; whereas the H18G reflected more random coil characteristics. The H18G induced structural alterations as to develop more random coil characteristics and more micro‐environmental changes around the tryptophan residues. This work suggested that His18 may not be a crucial binding site for Cu²⁺, but rather that it may be an important binding site for Zn²⁺ in terms of chaperone‐like activity and the process of metal induced self‐aggregation is prerequisite for chaperone‐like activity to occur.     

A game approach for cooperative spectrum sharing in cognitive radio networks

We consider the problem of cooperative spectrum sharing among primary users (PUs) and secondary users (SUs) in cognitive radio networks. In our system, each PU selects a proper set of SUs to serve as the cooperative relays for its transmission and in return, leases portion of channel access time to the selected SUs for their own transmission. PU decides how to select SUs and how much time it would lease to SUs, and the cooperative SUs decide their respective power levels in helping PU's transmission, which are proportional to their access times. We assume that both PUs and SUs are rational and selfish. In single‐PU scenario, we formulate the problem as a noncooperative game and prove that it converges to a unique Stackelberg equilibrium. We also propose an iterative algorithm to achieve the unique equilibrium point. We then extend the proposed cooperative mechanism to a multiple‐PU scenario and develop a heuristic algorithm to assign proper SUs to each PU considering both performance and fairness. The simulation results show that when the competition among SUs is fierce, the performance gap between our heuristic algorithm and the optimal one is smaller than 3%. Copyright © 2013 John Wiley & Sons, Ltd.     

A survey on genomic data by privacy-preserving techniques perspective

Nowadays, the purpose of human genomics is widely emerging in health-related problems and also to achieve time and cost-efficient healthcare. Due to advancement in genomics and its research, development in privacy concerns is needed regarding querying, accessing and, storage and computation of the genomic data. While the genomic data is widely accessible, the privacy issues may emerge due to the untrusted third party (adversaries/researchers), they may reveal the information or strategy plans regarding the genome data of an individual when it is requested for research purposes. To mitigate this problem many privacy-preserving techniques are used along with cryptographic methods are briefly discussed. Furthermore, efficiency and accuracy in a secure and private genomic data computation are needed to be researched in future.     

Cooperative spectrum sharing MIMO systems with successive decoding

A spectrum sharing system with primary and secondary nodes, each equipped with an arbitrary number of antennas, is investigated. Particularly, the outage performance of an underlay cognitive system is analytically studied, in the case when the end-to-end ($e2e$) communication is established via an intermediate relay node. To better enhance the $e2e$ communication, successive interference cancellation (SIC) is adopted, which compensates for both the transmission power constraint and the presence of interference from primary nodes. Both the relay and secondary receiver perform unordered SIC to successively decode the multiple streams, whereas the decode-and-forward relaying protocol is used for the $e2e$ communication. New closed-form expressions for the $e2e$ outage performance of each transmitted stream are derived in terms of finite sum series of the Tricomi confluent hypergeometric function. In addition, simplified yet tight approximations for the asymptotic outage performance are obtained. Useful engineering insights are manifested, such as the diversity order of the considered system and the impact of interference from the primary nodes in conjunction with the constrained transmission power of the secondary nodes.     

Site mapping and small molecule blind docking reveal a possible target site on the SARS-CoV-2 main protease dimer interface

The SARS-CoV-2 virus is causing COVID-19 resulting in an ongoing pandemic with serious health, social, and economic implications. Much research is focused in repurposing or identifying new small molecules which may interact with viral or host-cell molecular targets. An important SARS-CoV-2 target is the main protease (M^pro), and the peptidomimetic α-ketoamides represent prototypical experimental inhibitors. The protease is characterised by the dimerization of two monomers each which contains the catalytic dyad defined by Cys¹⁴⁵ and His⁴¹ residues (active site). Dimerization yields the functional homodimer. Here, our aim was to investigate small molecules, including lopinavir and ritonavir, α-ketoamide 13b, and ebselen, for their ability to interact with the M^pro. The sirtuin 1 agonist SRT1720 was also used in our analyses. Blind docking to each monomer individually indicated preferential binding of the ligands in the active site. Site-mapping of the dimeric protease indicated a highly reactive pocket in the dimerization region at the domain III apex. Blind docking consistently indicated a strong preference of ligand binding in domain III, away from the active site. Molecular dynamics simulations indicated that ligands docked both to the active site and in the dimerization region at the apex, formed relatively stable interactions. Overall, our findings do not obviate the superior potency with respect to inhibition of protease activity of covalently-linked inhibitors such as α-ketoamide 13b in the M^pro active site. Nevertheless, along with those from others, our findings highlight the importance of further characterisation of the M^pro active site and any potential allosteric sites.     

5G基站的配套改造方式浅析

随着5G商用牌照的发放,5G基站建设如火如荼地开展,5G基站的基础配套的改造需求变得越来越紧迫.现有基站的配套能力如何满足5G建设的需要,成为亟需面对和解决的问题.通过分析三大运营商5G网络的特点和架构,同时考虑多家运营商共享情况,并根据5G网络建设实施情况分析5G基站的塔桅抱杆、电源和外电的配套改造方案.     

Solvothermal Synthesis and Crystal Structure of a Layered Thioantimonate(Ⅲ) [C4H9NH3]2Sb4S7

An inorganic-organic hybrid thioantimonate(Ⅲ) [CH3(CH2)3NH3]2Sb4S7 1 with layered structure was synthesized by solvothermal method.1 crystallizes in the triclinic system, space group P with a = 7.0124(11), b = 11.919(2), c = 14.879(3) (A), α = 108.791(3), β = 102.441(3), γ = 92.846(2)o, V = 1140.1(3) (A)3, Mr = 859.71, Z = 2, Dc = 2.504 g/cm3, μ= 5.324 mm-1, F(000) = 804, S = 1.013, the final R = 0.0297 and wR = 0.0618 for 3534 observed reflections with I＞2σ(I). 1 consists of [C4H9NH3] cations and two-dimensional [Sb4S7]n2n-anion which is composed of three SbS3 trigonal pyramids and one SbS4 unit joined by sharing common corners. The anionic layers are stacked perpendicularly to the c axis of the unit cell forming two-dimensional channels between the layers. The [C4H9NH3] cations interdigitate in a bilayer and reside in the 2D channels leading to a sandwich-like arrangement of the anion and cations.