Epidemic spreading on random surfer networks with infected avoidance strategy

In this paper, we study epidemic spreading on random surfer networks with infected avoidance(IA) strategy. In particular, we consider that susceptible individuals' moving direction angles are affected by the current location information received from infected individuals through a directed information network. The model is mainly analyzed by discrete-time numerical simulations. The results indicate that the IA strategy can restrain epidemic spreading effectively. However,when long-distance jumps of individuals exist, the IA strategy's effectiveness on restraining epidemic spreading is heavily reduced. Finally, it is found that the influence of the noises from information transferring process on epidemic spreading is indistinctive.     

Optimal control and numerical methods for hybrid stochastic SIS models

This work focuses on optimal controls of a class of stochastic SIS epidemic models under regime switching. By assuming that a decision maker can influence the infectivity period, our aim is to minimize the expected discounted cost due to illness, medical treatment, and the adverse effect on the society. In addition, a model with the incorporation of vaccination is proposed. Numerical schemes are developed by approximating the continuous-time dynamics using Markov chain approximation methods. It is demonstrated that the approximation schemes converge to the optimal strategy as the mesh size goes to zero. Numerical examples are provided to illustrate our results.     

Characterization of the IF Noise of a Submillimeter SIS Receiver

A fitting method is presented here for the accurate characterization of the IF noise contribution of a sub-millimeter SIS receiver. By fitting the mixer's IF output power response and junction's IV curve of an SIS mixer without LO pumping, we can obtain the IF noise contribution, the physical temperature of the isolator connected just behind the SIS mixer, the output mismatching of the mixer, and the total gain of the IF chain. Differing from a conventional method, which only uses the normal-state (linear) branch of the junction's IV curve, the method proposed here also includes the nonlinear portion around the gap voltage. The dynamic resistance in this portion is varied dramatically, providing us a good probe to characterize the output mismatching of the mixer, as well as other parameters.     

Multifunctional Modification of SIS Membrane with Chimeric Peptides to Promote Its Antibacterial,Osteogenic, and Healing-Promoting Abilities for Applying to GBR

Guided bone regeneration (GBR) technology is the most widely used and stable method for bone defect repair. However, infectious bone defect limits the application of this technique. Herein, a small intestinal submucosa (SIS) membrane modified by chimeric peptides as a new type of GBR membrane is developed for efficacious tissue regeneration. Based on the main components of SIS membrane are I and III collagen, collagen binding peptides TKKTLRT and KELNLVY sequences are used to construct chimeric peptides with healing-promoting peptide Hst1 or antibacterial osteogenic peptide JH8194, so as to realize the specifically target of SIS. This method achieves the fast and efficient multifunctional modification of SIS membrane. The chimeric peptides modified SIS (pSIS) membrane has satisfactory biocompatibility and a certain degree of antibacterial activity. Moreover, pSIS promotes the osteogenic related factors expression of rat bone mesenchymal stem cells and demonstrates great bone regeneration in rat skull defect model. Furthermore, pSIS accelerates the migration of oral epithelial cells in vitro and activate integrin α3β1 signal pathway contribute to wound healing. This study presents a novel biomaterial design of GBR membrane, specifically for the treatment of infectious bone defects.     

Effect of an applied magnetic field on the performance of a sis receiver near 300 GHz

We have successfully constructed and tested a superconductor-insulator-superconductor (SIS) receiver for operation at 265–280 GHz using 1 m² area Nb–AlO _x –Nb tunnel junctions fabricated at Stony Brook. The best performance to date is a double sideband (DSB) receiver noise temperature of 129 K at 278 GHz. We find that suppression of the Josephson pair currents with a magnetic field is essential for good performance and a stable DC bias point. Fields as high as 280 gauss have been used with no degradation of mixing performance. We illustrate the improvement in the intermediate frequency (IF) output stability with progressively increasing magnetic fields.     

Dynamic properties of epidemic spreading on finite size complex networks

The Internet presents a complex topological structure, on which computer viruses can easily spread. By using theoretical analysis and computer simulation methods, the dynamic process of disease spreading on finite size networks with complex topological structure is investigated. On the finite size networks, the spreading process of SIS （susceptibleinfected-susceptible） model is a finite Markov chain with an absorbing state. Two parameters, the survival probability and the conditional infecting probability, are introduced to describe the dynamic properties of disease spreading on finite size networks. Our results can help understanding computer virus epidemics and other spreading phenomena on communication and social networks. Also, knowledge about the dynamic character of virus spreading is helpful for adopting immunity policy.     

Epidemic threshold and immunization on generalized networks

The susceptible–infected–susceptible (SIS) model is widely adopted in the studies of epidemic dynamics. When it is applied on contact networks, these networks mostly consist of nodes connected by undirected and unweighted edges following certain statistical properties, whereas in this article we consider the threshold and immunization problem for the SIS model on generalized networks that may contain different kinds of nodes and edges which are very possible in the real situation. We proved that an epidemic will become extinct if and only if the spectral radius of the corresponding parameterized adjacent matrix (PAM) is smaller than 1. Based on this result, we can evaluate the efficiency of immune strategies and take several prevailing ones as examples. In addition, we also develop methods that can precisely find the optimal immune strategies for networks with the given PAM.     

A second-order phase transition in the complete graph stochastic epidemic model

A stochastic model for epidemic spread in a set of individuals placed upon the sites of a complete graph of relations is investigated. The model is defined by three parameters: the number of individuals or sites, N, the probability that an infected site transmits the disease to a susceptible site, α, and the probability of recovery of infected sites, β, both referred to the unit of time.We show that this system evolves towards a, approximately Gaussian, stationary distribution of infected sites whose mean and variance can be analytically estimated. Also, we find that the average fraction of infected sites, x, is zero for transmission probabilities below the critical value α_c=1-e^-β/N and grows linearly with α for 0<α-α_c1. A sharp peak observed in Monte Carlo simulations of the variance of the number of infected sites as a function of α allows us to classify this dynamical phase transition as second order with x playing the role of an order parameter. Some consequences of this model to the dynamics of highly connected complex systems, such as the brain cortex, are also discussed.     

The Development of a Dual Channel SIS Receiver of Trao Telescope

We developed a low noise dual channel receiver with 100GHz and 150GHz band, which is used to make the simultaneous observation with two bands. The SIS mixers are used in both bands. The constructed dewar for the receiver has a performance with a vacuum of 10^–8torr and a temperature of 4.2K. The receiver noise temperature is 50K(DSB) for 100GHz band and 80K(DSB) for 150GHz band, respectively. In order to achieve the simultaneous observations, the quasioptical system is precisely designed, and also evaluated by measurements in the laboratory. The relative pointing offset between two bands is 3. We have observed the various sources using the receiver since October 1998.