柱边边缘扫描检出模型的研究

本文建立了两种通用的柱边边缘扫描（白光扫描和激光扫描）检出的理论模型，给出了这两种模型的计算机仿真曲线，分析了影响边缘检出灵敏度的因素，并通过三种边缘检出方法验证了这两种模型的正确性。     

中国网通的渠道建设浅析

阐述营销渠道相关概念，着重分析中国网通渠道模式特点，为中国网通的渠道管理(代理商管理)提出了一系列办法，得出最终赢得用户、占领市场的式关键是对代理商的有致管理及与其的顺畅合作的结论。     

基于自诊断、自适应技术的大型压缩机机组控制系统

随着自诊断、自适应技术在工业生产自动化控制系统中的应用越来越广泛,本文以莱钢大型压缩机机组为例,利用负荷自适应、冲击信号自修正模型、喘振响应仿真等技术手段,设计实现了压缩机节能变负荷运行、预防性喘振响应仿真及检测设备和基础自动化设备的在线故障自诊断和自修复.该系统投运后,大大减少了停机率,提高了设备运行效率和故障处理效率,可以推广到类似的控制系统中.     

二维离子注入的改进模型及数值模拟

本文提出了一个改进的二维离子注入模型.对于在任意形状掩蔽边界下的离子注入分布,我们在纵向采用联结的半高斯分布或修改过的Pearson-IV分布,在横向采用余误差函数分布,并且考虑了在多层掩蔽情况下各种材料阻止本领的不同.利用这一模型发展起来的离子注入模拟器能连续计算多次不同能量、剂量和杂质类型的注入分布,并考虑了多种不同掩蔽边界的影响.通过与其它工艺模拟器的比较,表明我们的模拟器在精度和功能上都有明显的改进.     

Numerical Study of φ4 Model by Potential Importance Sampling Method

We investigate the phenomena of spontaneous symmetry breaking for φ⁴ model on a square lattice in the parameter space by using the potential importance sampling method, which was proposed by Milchev, Heermann, and Binder [J. Stat. Phys. 44 (1986) 749]. The critical values of the parameters allow us to determine the phase diagram of the model. At the same time, some relevant quantities such as susceptibility and specific heat are also obtained.     

Investigation of the Uptake and Transport of Two Novel Camptothecin Derivatives in Caco-2 Cell Monolayers

Irinotecan and Topotecan are two Camptothecin derivatives (CPTs) whose resistance is associated with the high expression of breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp). To reverse this resistance, two novel CPTs, FL77-28 (7-(3-Fluoro-4-methylphenyl)-10,11-methylenedioxy-20(S)-CPT) and FL77-29 (7-(4-Fluoro-3-methylphenyl)-10,11-methylenedioxy-20(S)-CPT), were synthesized by our group. In this study, the anti-tumor activities of FL77-28, FL77-29, and their parent, FL118 (10,11-methylenedioxy-20(S)-CPT), were evaluated and the results showed that FL77-28 and FL77-29 had stronger anti-tumor activities than FL118. The transport and uptake of FL118, FL77-28, and FL77-29 were investigated in Caco-2 cells for the preliminary prediction of intestinal absorption. The apparent permeability coefficient from apical to basolateral (P_{app AP-BL}) values of FL77-28 and FL77-29 were (2.32 ± 0.04) × 10⁻⁶ cm/s and (2.48 ± 0.18) × 10⁻⁶ cm/s, respectively, suggesting that the compounds had moderate absorption. Since the transport property of FL77-28 was passive diffusion and the efflux ratio (ER) was less than 2, two chemical inhibitors were added to further confirm the involvement of efflux proteins. The results showed that FL77-28 was not a substrate of P-gp or BCRP, but FL77-29 was mediated by P-gp. In conclusion, FL77-28 might be a promising candidate to overcome drug resistance induced by multiple efflux proteins.     

Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study

Human dihydroorotate dehydrogenase (hDHODH) is an enzyme belonging to a flavin mononucleotide (FMN)-dependent family involved in de novo pyrimidine biosynthesis, a key biological pathway for highly proliferating cancer cells and pathogens. In fact, hDHODH proved to be a promising therapeutic target for the treatment of acute myelogenous leukemia, multiple myeloma, and viral and bacterial infections; therefore, the identification of novel hDHODH ligands represents a hot topic in medicinal chemistry. In this work, we reported a virtual screening study for the identification of new promising hDHODH inhibitors. A pharmacophore-based approach combined with a consensus docking analysis and molecular dynamics simulations was applied to screen a large database of commercial compounds. The whole virtual screening protocol allowed for the identification of a novel compound that is endowed with promising inhibitory activity against hDHODH and is structurally different from known ligands. These results validated the reliability of the in silico workflow and provided a valuable starting point for hit-to-lead and future lead optimization studies aimed at the development of new potent hDHODH inhibitors.     

智能超表面辅助低轨卫星通信技术综述

卫星通信能够提供超视距、大容量的通信服务,但在城市区域、峡谷森林等视线受遮蔽严重的区域,会出现视距衰落严重、多径效应显著等问题,影响通信质量。近年来出现的智能超表面(RIS)可以通过动态控制反射单元的电磁性质,构建可控电磁环境,为改善低轨(LEO)卫星通信质量提供新的思路。本文基于RIS基本原理与优势,对RIS用于LEO卫星通信中信道建模、信道估计、波束成形等关键技术进行探讨,最后分析了目前RIS在实际应用中面临的主要挑战,以期为LEO卫星场景下的RIS研究提供参考。     

基于二分搜索的宽带多普勒模型信号捕获方法

针对深空通信等超高动态低信噪比通信场景中,传统信号捕获方法存在着动态范围不足、精确度不够以及使用窄带多普勒模型导致对接收信号近似精确度不高的问题,提出一种基于二分搜索的接收端采样率调整方法。使用宽带多普勒模型对接收信号进行建模,并使用扫频余弦类信号进行多普勒频偏估计和定时估计,处理多普勒伸缩后的信号与本地信号采样率不匹配的问题。对所提方法进行同步性能仿真,仿真结果表明,所提方法采用正反扫频线性调频(UD-LFM)信号,能在信噪比为-49 dB、最大多普勒频偏为2 MHz的条件下,多普勒频偏估计误差小于400 Hz,定时估计误差不超过60 ns。相比不使用本文所提方法进行直接捕获,本文所提方法具有更高的捕获精确度以及更低的信噪比门限。     

实测卫星频谱占用状态拟合与预测方法

由于在不同时间、不同空间卫星接收数据底噪是动态起伏的,传统建模固定门限的方法存在缺陷。本文在时间维度上对卫星频谱感知数据的频谱占用模型进行分析,利用自适应阈值法确定噪声门限,对卫星频谱数据进行预处理,得到卫星频谱占用长度序列。为对卫星频谱的态势进行有效的统计分析,利用泊松分布和指数分布方法对频谱占用时间长度序列的概率密度曲线进行拟合,得到了适用于卫星频谱占用时间序列的概率分布模型。基于所得的卫星频谱占用状态模型,通过两状态马尔可夫链计算出卫星信道某一频点的状态转移矩阵,从而预测出信道占用和空闲的概率。利用卫星频谱感知数据构建的数据集进行反向传播(BP)神经网络训练,预测某一频点的占用长度。通过计算BP神经网络与传统的长短期记忆(LSTM)神经网络预测法的均方根误差(RMSE),得到LSTM神经网络的RMSE为2.208 1,BP神经网络的RMSE为0.172 8。评估结果表明,BP神经网络准确度高。