宁波民众对"非典疫情"风险认知的调查研究

运用问卷，通过对宁波地区730名民众的调查，研究了人们对非典疫情的风险认知特点及其行为反应，结果表明：非典疫情发布的信息渠道影响民众对非典的风险认知，宁波民众主要是通过分析控制患者死亡的数量来评估非典风险的大小；民众对非典疫情的熟悉度也影响风险认知；不同性别和不同职业群体对非典疫情的心理反应和预警存在一定差异，女性在面对非典危险时相对表现更紧张，农村居民面对非典疫情的认识、心理及行为状况与其他群体的差异较大。     

SARS流行病传染动力学模型

建立了 SARS流行病的数学模型 ,根据部分国家和地区的 SARS疫情数据 ,计算出其模型参数 ,给出了各地 SARS疫情与模拟结果的比较图 ,模拟结果与实际疫情十分吻合 .分析了 SARS流行特征 ,并对疫情发展进行了预测 .     

SARS数学模型解的存在唯一性与稳定性

讨论了一种带年龄结构的SARS疾病模型，它是一组非线性偏微分方程组，应用有界线性算子的C0一半群理论及非线性扰动理论，证明了该方程组非负解的存在唯一性及稳定性．     

对SARS病房建设中有关安全等级的浅见

本文通过对SARS(非典型肺炎)病毒的危险度分析，确立其医疗病房的防护等级，并依据笔者的实践经验，提出SARS(非典型肺炎)病毒传染医疗用房的安全等级和建设中的若干问题。     

Impact of Coronavirus Outbreaks on Science and Society: Insights from Temporal Bibliometry of SARS and COVID-19

A global event such as the COVID-19 crisis presents new, often unexpected responses that are fascinating to investigate from both scientific and social standpoints. Despite several documented similarities, the coronavirus pandemic is clearly distinct from the 1918 flu pandemic in terms of our exponentially increased, almost instantaneous ability to access/share information, offering an unprecedented opportunity to visualise rippling effects of global events across space and time. Personal devices provide “big data” on people’s movement, the environment and economic trends, while access to the unprecedented flurry in scientific publications and media posts provides a measure of the response of the educated world to the crisis. Most bibliometric (co-authorship, co-citation, or bibliographic coupling) analyses ignore the time dimension, but COVID-19 has made it possible to perform a detailed temporal investigation into the pandemic. Here, we report a comprehensive network analysis based on more than 20,000 published documents on viral epidemics, authored by over 75,000 individuals from 140 nations in the past one year of the crisis. Unlike the 1918 flu pandemic, access to published data over the past two decades enabled a comparison of publishing trends between the ongoing COVID-19 pandemic and those of the 2003 SARS epidemic to study changes in thematic foci and societal pressures dictating research over the course of a crisis.     

传染病模型的研究及应用

分析了传染病的传播扩散特点,建立了传染病传播扩散的微分方程模型.利用最大似然估计法对模型中的参数进行了估计.并以SARS传染扩散为例,利用网上的公开数据对模型进行了检验,所得结果与实际情况一致.此模型为传染病的预防和控制提供了理论依据.     

Synthesis and Biological Evaluation of Quinolinone Compounds as SARS CoV 3CL^pro Inhibitors

SARS CoV 3CL^pro is known to be a promising target for development of therapeutic agents against the severe acute respiratory syndrome （SARS）. A quinolinone compound 1 was selected via virtual screening, and it was syn- thetized and tested for enzymatic inhibition in vitro. Compound 1 showed potent inhibitory activity （ICs0= 0.44 μmol/L） toward SARS CoV 3CL^pro. Further work on a series of quinolinone derivatives resulted in the discovery of the most potent compound 23, inhibiting SARS CoV 3CL^pro with an IC50 of 36.86 μmol/L. The structure-activity relationships were also discussed.     

SARS冠状病毒3CL蛋白酶及其抑制剂的理论研究

应用AutoDock程序将SARS冠状病毒3CL蛋白酶及其抑制剂配体和受体进行了对接,并用InsightⅡ中的Discover 3模块进行了分子动力学模拟,分析了蛋白酶活性口袋的形状,讨论了其亚基的氢键、静电、疏水等相互作用,为进一步设计药物提供了重要的参考信息.     

生物学安全设施与21世纪

主要论述当前有关生物学安全设施的生物学危险特点及防护要求。     

六钼酸盐有机胺杂化衍生物与SARS-CoV 3CLpro相互作用的分子动力学模拟

采用分子动力学模拟方法, 在分子水平上探讨六钼酸盐有机杂化衍生物潜在的抗SARS病毒活性. 3CLpro主蛋白酶是冠状病毒复制和转录过程中起关键作用的功能蛋白, 因此采用SARS-CoV 3CLpro作为靶标进行抗SARS病毒的药物设计. 使用Insight II软件包中的Biopolymer, Discover 3, Profile-3D和Affinity等模块, 研究 POMs/3CLpro相互作用的结合位点和作用性质. 研究其能量变化规律, 探讨了多酸化合物对SARS病毒可能的抑制机理. 研究结果表明, POMs与3CLpro在酶的催化活性位点处有较强的结合力. 形成的复合物主要以静电相互作用相结合, 氢键相互作用对复合物的相对稳定性有一定影响. 对于POMs/3CLpro复合物, 有机胺基团取代的POMs所带负电荷比未取代体系的高, 比3CLpro的结合能更高, 这与POMs的相关量子化学计算结果吻合.