四川地区宫颈癌组织HPV18和HPV45 E6基因突变分析

采用聚合酶链反应技术对四川地区2003~2004年收集的60例宫颈癌患者的癌组织DNA进行人乳头瘤病毒(HPV) E6基因扩增, 获得HPV18和45型E6基因. 序列分析发现, 18型三例E6基因有同样的两处同义突变; 45型两例E6基因发生突变, 一例有两处碱基突变, 另一例发生六处碱基突变, 其中两处涉及氨基酸变化, 均位于E6抗原决定簇区. HPV45型E6基因中134位c→t, 157位c→t, 259位g→t和341位t→c的碱基点突变未见报道. 另外， 该地区HPV18和45型突变株之间存在碱基互变,  它们之间的最小差异比野生型HPV18和HPV45之间的差异小4.05%, 该数值比在非洲发现的突变株的要小很多, 该结果支持HPV18和HPV45可能起源于非洲的观点.     

Symmetric Skorohod topology onn-variable functions and hierarchical Markov properties ofn-parameter processes

Summary We introduce a new Skorohod topology for functions of several variables. Since ann-variable function may be viewed as a one-variable function with values in the set of (n–1)-variable functions, this topology is defined by induction from the classical Skorohod topology for one-variable functions. This allows us to define the notion of completen-parameter symmetric Markov processes: Such processes are, for any 1pn, rawp-parameter Markov processes (in the sense of our previous paper [17]) with values in the space of (n–p)-variable functions. We prove, for these processes and their Bochner subordinates, a maximal inequality which implies the continuity of additive functionals associated with finite energy measures. We finally present several important examples.     

The cohomology of invariant variational bicomplexes

Let: E M be a fiber bundle and let be an infinitesimal Lie transformation group acting onE. We announce various new results concerning the cohomology of the invariant variational bicomplex ( ^*,* (J(E)), d_H, d_V) and the associated invariant Euler-Lagrange complex. As one application of our general theory, we completely solve the local invariant inverse problem of the calculus of variations for finite-dimensional infinitesimal Lie transformation groups.     

A normalization problem for a class of singular integral operators with carleman shift and unbounded coefficients

The solution to a normalization problem for singular integral operators with Carleman shift and degenerate and unbounded coefficients inL _p () is obtained, where is either the unit circle or the real line. The approach followed consists mainly in two steps: the reduction to a singular integral operator with bounded coefficients and the use of the solution to an abstract normalization problem.This research was supported by JNICT under the grant PBIC/C/CEN/1040/92.     

Properties of certain integral operators

Two integral operatorsP andQ for analytic functions in the open unit disk are introduced. The object of the present paper is to derive some properties of integral operatorsP andQ .     

Arbres,espaces ultramétriques et bases de structure uniforme

Résumé On décrit une bijection canonique qui associe à un bon espace ultramétrique, localement compact, non compact, un arbre pointé par un bout: cet espace s'identifie à l'ensemble des autres bouts.

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We describe a canonical bijection, which associates a tree with a chosen end to a nice ultrametric, locally compact, non-compact space: this space is identified with the set of other ends.

     

New lower semicontinuity results for polyconvex integrals

Summary We study integral functionals of the formF(u, )= f(u)dx, defined foru C¹(;R ^k), R ⁿ . The functionf is assumed to be polyconvex and to satisfy the inequalityf(A) c₀¦(A)¦ for a suitable constant c₀ > 0, where (A) is then-vector whose components are the determinants of all minors of thek×n matrixA. We prove thatF is lower semicontinuous onC ¹(;R ^k) with respect to the strong topology ofL ¹(;R ^k). Then we consider the relaxed functional , defined as the greatest lower semicontinuous functional onL ¹(;R ^k ) which is less than or equal toF on C¹(;R ^k). For everyu BV(;R ^k) we prove that (u,) f(u)dx+c₀¦D^su¦(), whereDu=u dx+D^su is the Lebesgue decomposition of the Radon measureDu. Moreover, under suitable growth conditions onf, we show that (u,)= f(u)dx for everyu W^1,p(;R ^k), withp min{n,k}. We prove also that the functional (u, ) can not be represented by an inte- gral for an arbitrary functionu BV_loc(R ⁿ;R ^k). In fact, two examples show that, in general, the set function (u, ) is not subadditive whenu BV_loc(R ⁿ;R ^k), even ifu W _loc ^1,p (R ⁿ;R ^k) for everyp < min{n,k}. Finally, we examine in detail the properties of the functionsu BV(;R ^k) such that (u, )= f(u)dx, particularly in the model casef(A)=¦(A)¦.     

Sur le comportement asymptotique des potentiels d'une chaîne de Markov sur ℝ d

Résumé Dans cet article j'étudie le comportement à l'infini des potentiels des chaînes de Markov sur ^d (d3) proches du mouvement brownien, tout spécialement le cas des marches aléatoires, ainsi que des critères de transience et de récurrence inspirés de la méthode utilisée.

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We study the asymptotic behaviour of potentials of Markov chains on ^d (d3), closed to Brownian motion, and particularly the case of random walks. Following a similar approach, we give transience and recurrence criteria.

     

On some global well-posedness and asymptotic results for quasilinear parabolic equations

We prove that the quasilinear parabolic initial-boundary value problem (1.1) below is globally well-posed in a class of high order Sobolev solutions, and that these solutions possess compact, regular attractors ast+.     

On tile-k-transitive tilings of the space

General methods for finding tile-k-transitive tilings of the three-dimensional Euclidean space with polyhedral bodies are discussed. Analogous methods for enumerating k-isohedral tilings of a two-dimensional plane of constant curvature have been obtained previously.