Insights into the Allosteric Effect of SENP1 Q597A Mutation on the Hydrolytic Reaction of SUMO1 via an Integrated Computational Study

Small ubiquitin-related modifier (SUMO)-specific protease 1 (SENP1) is a cysteine protease that catalyzes the cleavage of the C-terminus of SUMO1 for the processing of SUMO precursors and deSUMOylation of target proteins. SENP1 is considered to be a promising target for the treatment of hepatocellular carcinoma (HCC) and prostate cancer. SENP1 Gln597 is located at the unstructured loop connecting the helices α4 to α5. The Q597A mutation of SENP1 allosterically disrupts the hydrolytic reaction of SUMO1 through an unknown mechanism. Here, extensive multiple replicates of microsecond molecular dynamics (MD) simulations, coupled with principal component analysis, dynamic cross-correlation analysis, community network analysis, and binding free energy calculations, were performed to elucidate the detailed mechanism. Our MD simulations showed that the Q597A mutation induced marked dynamic conformational changes in SENP1, especially in the unstructured loop connecting the helices α4 to α5 which the mutation site occupies. Moreover, the Q597A mutation caused conformational changes to catalytic Cys603 and His533 at the active site, which might impair the catalytic activity of SENP1 in processing SUMO1. Moreover, binding free energy calculations revealed that the Q597A mutation had a minor effect on the binding affinity of SUMO1 to SENP1. Together, these results may broaden our understanding of the allosteric modulation of the SENP1−SUMO1 complex.     

Gabor Analysis on Finite Product of Cyclic Groups

We present a complete characterization of Gabor frame operators on finite dimensional Hilbert space $L^2(\Gamma)$, where $\Gamma = \mathbb{Z}_{m_1} \times \mathbb{Z}_{m_2} \times \dots \times \mathbb{Z}_{m_p}$ and $m_1,m_2,\dots,m_p$ are positive integers. The notion of generalized $B$-modulation and generalized $B$-translation is introduced and some significant properties of the generalized pseudo $B$-Gabor like frames are discussed.     

电镀法制备CoNiMnP永磁薄膜研究

采用电子能谱仪(EDS)与振动样品磁强计(VSM),研究了电流密度及镀液pH值对电镀CoNiMnP永磁薄膜矫顽力的影响。结果表明:CoNiMnP永磁薄膜具有明显的垂直各向异性,且随电流密度和镀液pH值的增大,CoNiMnP薄膜的矫顽力呈先增大后降低的变化;当电流密度为5×10–3A/cm2、镀液pH值为5时,CoNiMnP薄膜垂直方向的矫顽力Hcj达到最大值80kA·m–1。     

保密通信中的分形调制技术

分形调制在保密通信中具有广阔的应用前景。介绍了分形调制的原理,讨论了其在多速率分集、抗1/f噪声、抗频率选择性衰落、适用于信道条件复杂的MIMO通信系统等方面的特点。由于作为密钥的小波基任意多,且可根据信道情况在不同的小波基之间跳变,故分形调制具有极强的保密性和抗破译能力。     

基于差分空时调制的混沌慢跳频系统

提出一种慢跳频系统中基于差分空时调制的混沌保密通信方法。此方案集成了差分空时编码和混沌跳频扩频技术的优点。一方面,在跳频系统中,使用混沌序列代替伪随机(PN)码,增强了抗截获和抗预测的性能;另一方面,通过差分空时调制产生分集增益,降低了多径衰落效应的影响。仿真结果证实了此方案的有效性。     

高储能密度玻璃-陶瓷电容器内电极的研究

采用Na2O-PbO-Nb2O5-SiO2体系玻璃-陶瓷作为绝缘介质,以磁控溅射镀膜技术先在玻璃-陶瓷层表面形成金属膜,再用丝网印刷技术在金属膜上涂覆银浆形成组合式内电极,制备出多层结构高储能密度玻璃-陶瓷电容器,对比了单层内电极结构电容器的性能参数。结果表明:多层内电极结构既保证电容器电极面积不会因银浆烧结形成微孔而减小,又能从原理上有效提高电容元件的击穿强度,其储能密度提高到约8 J/cm3。     

基于Transformer的通信信号调制识别方法

提出一种基于Transformer模型的通信信号调制识别方法：在数据准备阶段,构建一个不同符号速率调制识别(DSRMR)数据集;在数据预处理阶段,提出I/Q数据增强方法,用于满足模型训练在数量上和多样性的要求,增强了模型泛化能力;在模型构建阶段,将切片序列化的方法引入调制识别Transformer模型中,用于优化Transformer神经网络模型的输入问题。实验结果证明,基于Transformer模型的通信信号调制识别方法能够获得较高的信号自动调制识别准确率。     

基于DFB激光器的振动传感系统改进PGC解调算法

相位生成载波(Phase Generated Carrier, PGC)解调算法是目前光纤干涉传感领域中重要的解调算法。针对目前PGC解调算法中光强扰动和调制深度影响信号解调准确度的问题,提出了一种改进的PGC解调算法(PGC-Ameliorated),并搭建了基于分布反馈(Distributed Feedback, DFB)激光器的振动传感系统进行实验验证。实验结果表明,当被测振动信号的频率为800 Hz时,该算法信噪比为57 dB,优于微分交叉相乘(Differential and Cross Multiplying, DCM)算法和反正切(Arctan)算法近20 dB。在不同光强下,该算法解调信号幅值波动范围在±0.02 rad;在不同调制深度下,该算法总谐波失真最小为0.61%,信纳比最大为25.9 dB,相比于DCM算法和Arctan算法具有更低的总谐波失真和更高的信纳比。     

Cross-layer modeling of adaptive wireless links for QoS support in heterogeneous wired-wireless networks

Future wired-wireless multimedia networks require diverse quality-of-service (QoS) support. To this end, it is essential to rely on QoS metrics pertinent to wireless links. In this paper, we develop a cross-layer model for adaptive wireless links, which enables derivation of the desired QoS metrics analytically from the typical wireless parameters across the hardware-radio layer, the physical layer and the data link layer. We illustrate the advantages of our model: generality, simplicity, scalability and backward compatibility. Finally, we outline its applications to power control, TCP, UDP and bandwidth scheduling in wireless networks. The work by Q. Liu and G. B. Giannakis are prepared through collaborative participation in the Communications and Networks Consortium sponsored by the U.S. Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0011. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation thereon. The work by S. Zhou is supported by UConn Research Foundation internal grant 445157. Qingwen Liu (S’04) received the B.S. degree in electrical engineering and information science in 2001, from the University of Science and Technology of China (USTC). He received the M.S. degree in electrical engineering in 2003, from the University of Minnesota (UMN). He currently pursues his Ph.D. degree in the Department of Electrical and Computer Engineering at the University of Minnesota (UMN). His research interests lie in the areas of communications, signal processing, and networking, with emphasis on cross-layer analysis and design, quality of service support for multimedia applications over wired-wireless networks, and resource allocation. Shengli Zhou (M’03) received the B.S. degree in 1995 and the M.Sc. degree in 1998, from the University of Science and Technology of China (USTC), both in electrical engineering and information science. He received his Ph.D. degree in electrical engineering from the University of Minnesota, 2002, and joined the Department of Electrical and Computer Engineering at the University of Connecticut, 2003. His research interests lie in the areas of communications and signal processing, including channel estimation and equalization, multi-user and multi-carrier communications, space time coding, adaptive modulation, and cross-layer designs. He serves as an associate editor for IEEE Transactions on Wireless Communications since Feb. 2005. G. B. Giannakis (Fellow’97) received his Diploma in Electrical Engineering from the National Technical University of Athens, Greece, 1981. From September 1982 to July 1986 he was with the University of Southern California (USC), where he received his MSc. in Electrical Engineering, 1983, MSc. in Mathematics, 1986, and Ph.D. in Electrical Engineering, 1986. After lecturing for one year at USC, he joined the University of Virginia in 1987, where he became a professor of Electrical Engineering in 1997. Since 1999 he has been a professor with the Department of Electrical and Computer Engineering at the University of Minnesota, where he now holds an ADC Chair in Wireless Telecommunications. His general interests span the areas of communications and signal processing, estimation and detection theory, time-series analysis, and system identification -- subjects on which he has published more than 200 journal papers, 350 conference papers and two edited books. Current research focuses on transmitter and receiver diversity techniques for single- and multi-user fading communication channels, complex-field and space-time coding, multicarrier, ultra-wide band wireless communication systems, cross-layer designs and sensor networks. G. B. Giannakis is the (co-) recipient of six paper awards from the IEEE Signal Processing (SP) and Communications Societies (1992, 1998, 2000, 2001, 2003, 2004). He also received the SP Society’s Technical Achievement Award in 2000. He served as Editor in Chief for the IEEE SP Letters, as Associate Editor for the IEEE Trans. on Signal Proc. and the IEEE SP Letters, as secretary of the SP Conference Board, as member of the SP Publications Board, as member and vice-chair of the Statistical Signal and Array Processing Technical Committee, as chair of the SP for Communications Technical Committee and as a member of the IEEE Fellows Election Committee. He has also served as a member of the IEEE-SP Society’s Board of Governors, the Editorial Board for the Proceedings of the IEEE and the steering committee of the IEEE Trans. on Wireless Communications.     

304不锈钢板料激光热应力成形试验研究

通过改变激光功率、扫描速度、光斑直径、扫描次数及板料宽度对2 mm厚度的AISI304不锈钢板料进行激光热应力弯曲试验, 分析了各工艺参数对弯曲角度的影响规律, 对工件表面烧蚀情况进行评价, 并对板料金相组织进行观察分析。试验结果表明: 在试验参数范围内激光扫描次数、光斑直径、扫描速度和板料宽度对弯曲角度呈近似线性规律, 而激光功率对弯曲角度的影响不呈线性规律; 较大的面能量密度产生较大的弯曲角度。可通过工艺参数的合理组合在保证板料表面质量的前提下采用较大的面能量密度进行扫描以提高弯曲变形的效率。以上研究为精确控制板料激光弯曲成形奠定基础。