模拟朗缪尔探针伏安特性的非线性电子负载的设计与样机研制

研发了一套模拟朗缪尔探针伏安特性的非线性电子负载,由载波相移正弦脉宽调制(CPS-SPWM)技术的级联型H桥变流器与双向DC/DC变换器两部分组成.通过对电子负载设计方案开展建模仿真验证及样机初步测试表明,该系统基本达到了预期要求,可用于探针电源相关参数的测试及探针后端电子学系统的联合调试.     

接枝共聚物聚苯乙烯－g－聚氧乙烯的微相分离形态研究

本文利用透射电子显微镜技术，以两性接校共聚物聚苯乙烯－ｇ－聚氧乙烯为研究对象，研究了接枝共聚物的微相分离形态结构，发现聚苯乙烯－ｇ－聚氧乙烯能形成微相分离结构，微区的形状和尺寸与共聚物的组成和侧链长度有关．文中还讨论了嵌段共聚物和接枝共聚物在形成微相分离结构时的共性和个性．     

Synthesis of a hydrophilic and non-ionic anthracene derivative, the N,N′-di-(2,3-dihydroxypropyl)-9,10-anthracenedipropanamide as a chemical trap for singlet molecular oxygen detection in biological systems

We report herein the synthesis of a new hydrophilic and non-ionic anthracene derivative, the N,N′-di-(2,3-dihydroxypropyl)-9,10-anthracenedipropanamide. The evaluation of this compound as chemical trap of singlet molecular oxygen by using labeling experiments and HPLC-MS analysis showed that it could be efficiently used in biological investigations.     

定位生长法制备AFM单壁碳纳米管针尖

采用粘性胶状物作为生长单壁碳纳米管(SWNTs)的催化剂前驱体, 在原子力显微镜下驱动废旧的硅探针粘附该种胶状物,随后进行化学气相沉积(CVD), 实现了SWNTs在硅探针末端的定位生长, 成功地制备出了SWNT针尖. 对SWNTs及SWNT 针尖进行了表征, 并对针尖的稳定成像条件进行了分析. 结果表明, 针尖一般由5-10 nm 的SWNT 管束构成, 伸出长度仅为几百纳米, 受热振动影响较小, 无需后处理即可稳定地成像, 成像分辨率与新的硅探针相当.     

A microfluidic biosensor based on nucleic acid sequence recognition

The development of a generic semi-disposable microfluidic biosensor for the highly sensitive detection of pathogens via their nucleic acid sequences is presented in this paper. Disposable microchannels with defined areas for capture and detection of target pathogen RNA sequence were created in polydimethylsiloxane (PDMS) and mounted onto a reusable polymethylmethacrylate (PMMA) stand. Two different DNA probes complementary to unique sequences on the target pathogen RNA serve as the biorecognition elements. For signal generation and amplification, one probe is coupled to dye encapsulated liposomes while the second probe is coupled to superparamagnetic beads for target immobilization. The probes hybridize to target RNA and the liposome–target-bead complex is subsequently captured on a magnet. The amount of liposomes captured correlates directly to the concentration of target sequence and is quantified using a fluorescence microscope. Dengue fever virus serotype 3 sequences and probes were used as a model analyte system to test the sensor. Probe binding and target capture conditions were optimized for sensitivity resulting in a detection limit of as little as 10 amol L^–1 (10 pmol L^–1) . Future biosensors will be designed to incorporate a mixer and substitute the fluorescence detection with an electrochemical detection technique to provide a truly portable microbiosensor system.     

半椭球形和子弹头形光纤传感探头的耦合特性

 利用光路追踪程序，对于不同光纤参数条件下半椭球形和子弹头形光纤传感探头的耦合特性进行了研究。研究结果表明：对于半椭球形探头，当长短轴之比在1.15和1.3附近时存在一个耦合最佳结构；而对于子弹头形探头，仅变成圆形时为最佳。这两种探头容易制作，半椭球形探头的耦合效率高于子弹头形。     

在线测试技术的现状和发展

以电气接触为手段,在线测试设备除了能够测试制造过程的缺陷和故障以外,还能够测试 PCB的某些电气性能,因而得到了广泛应用。但是,在线测试仪将面临高密度PCB测试的挑战。文章扼要地介绍在线测试技术的原理及未来发展趋势。     

悬浮进样探针原子化石墨炉原子吸收法测定地质样品中的铬

本文应用探针恒温原子化技术 ,系统研究了铬的分析性能 ,应用固体悬浮进样 ,直接测定了地质样品中的痕量铬 ,方法的 RSD为 3.0 %～ 6 .5 % ,检测限为 5 .1× 10 - 1 2 g铬 ,标准物质的测定结果满意     

分子影像探针

分子影像是近年出现并迅速发展的一个生物医学领域,在疾病的治疗与诊断中发挥着重要作用。同时它又是一门交叉学科,涉及化学、医学、生物、计算机科学、放射科学、材料科学等。分子影像的发展除了需要先进的成像设备外,最关键的是合成新型而高效的成像探针。目前,分子影像探针广泛应用于科学研究和临床,并且也取得了巨大进步。本文主要综述了5种常见的分子影像探针:超声成像探针、X-射线计算机断层成像探针、光学成像探针、核磁共振成像探针、正电子发射计算机断层扫描成像探针,并对分子影像探针的应用进行了概述,最后对分子影像探针的发展进行了展望。