On optimal management of resources in distributed networks

In a network of processors, a distributed operating system must handle the management of shared resources. In this paper, it is shown how to solve this problem in using the model previously introduced in [1]. This model (interconnection of N Markov chains each representing locally a distributed process) allows us to prove the good functioning properties for some distributed problems such as the mutual exclusion problem and the deadlock problem, We also prove that fairness is a basic notion for setting the model’s parameters and obtain an optimal working of the network.     

Estimation of the Solubility of Sulfonamides in Aqueous Media from Partition Coefficients and Entropies of Fusion

Semi empirical equation developed by Yalkowsky and Valvani, and another equation extended by Jain and Yalkowsky were used to estimate the aqueous solubility S w , of some sulfonamides using experimental octanol-water partition coefficients P , entropies of fusion j S f , and melting points t m , determined by DSC measurements. The calculated solubilities were compared with those experimentally determined. When experimental j S f and t m were used, the S w calculated values were in good agreement in most cases.     

Asymmetric Schiff Base (N 2 O 3 ) Complexes as Ligands Towards Mn(II), Fe(III) and Co(II), Synthesis and Characterization

Heterobi- and tri-nuclear complexes [LMM'Cl] and [(LM) 2 M'](M=Ni or Cu and M'=Mn, Fe or Co) have been synthesised. The heteronuclear complexes were prepared by stepwise reactions using two mononuclear Ni(II) and Cu(II) complexes of the general formula [HLM]·1/2H 2 O, as ligands towards the metal ions, Mn(II), Fe(III) and Co(II). The asymmetrical pentadentate (N 2 O 3 ) Schiff-base ligands used were prepared by condensing acetoacetylphenol and ethylenediamine, molar ratio 1 1, to yield a half-unit compound which was further condensed with either salicylaldehyde or naphthaldehyde to yield the ligands H 3 L 1 and H 3 L 2 which possess two dissimilar coordination sites, an inner four-coordinate N 2 O 2 donor set and an outer three-coordinated O 2 O set. 1 H NMR and IR spectra indicate that the Ni(II) and Cu(II) ions are bonded to the inner N 2 O 2 sites of the ligands leaving their outer O 2 O sites vacant for further coordination. Different types of products were obtained according to the type of metal ion. These products differ in stoichiometry according to the type of ligand in the parent compound. Electronic spectra and magnetic moments indicate that the structures of the parent Ni(II) and Cu(II) complexes are square-planar while the geometry around Fe(III), Mn(II) and Co(II) in their products are octahedral as elucidated from IR, UV-visible, ESR, 1 H NMR, mass spectrometry and magnetic moments.     

深亚微米数字集成电路的自动化设计方法学

介绍了基于标准单元库的数字集成电路设计流程和方法学。数字集成电路设计流程从行为级的HDL描述开始，依次进行系统行为级仿真，行为级综合，RTL仿真，逻辑综合，综合后仿真，自动化布局布线，版图后仿真等步骤。讨论了如何把物理设计环境和逻辑设计环境联系起来，以解决物理设计和逻辑设计相脱节的问题。     

海面上电大尺寸目标电磁散射特性研究

基于几何光学法(GO)、物理光学法(PO)、射线弹跳法(SBR)和等效电流法(MEC),提出了一种快速计算金属海面上电大尺寸目标电磁散射的解析算法。该算法考虑了阴影效应,运用GO/PO+SBR计算了目标与海面的镜面反射以及它们之间的多次相互作用,并运用MEC计算了目标的棱边绕射以改进计算结果。应用该算法计算了平板上方规则金属目标的双站雷达散射截面(RCS),并与传统矩量法(MoM)进行比较,验证了算法的有效性。最后,计算了PM(Pierson-Moskowitz)海浪谱的随机海洋粗糙面上舰船模型目标的散射特性,并对计算结果进行了分析,讨论了海洋面以及入射波参数对散射结果的影响。     

Homoclinic and Heteroclinic Flows in Global Attractor for Davey-stewartson Ⅱ Equation

By the variable transformation and generalized Hirota method,exact homoclinic and heteroclinic solutions for Davey-StewartsonⅡ(DSⅡ)equation are obtained.For perturbed DSⅡequation,the existence of a global attractor is proved.The persistence of homoclinic and heteroclinic flows is investigated,and the special homoclinic and heteroclinic structure in attractors is shown.     

Modeling of enzyme–substrate complexes for the metalloproteases MMP-3, ADAM-9 and ADAM-10

The matrix metalloproteases (MMPs) and the ADAMs (A Disintegrin And Metalloprotease domain) are proteolytic enzyme families containing a catalytic zinc ion, that are implicated in a variety of normal and pathological processes involving tissue remodeling and cancer. Synthetic MMP inhibitors have been designed for applications in pathological situations. However, a greater understanding of substrate binding and the catalytic mechanism is required so that more effective and selective inhibitors may be developed for both experimental and clinical purposes. By modeling a natural substrate spanning P4-P4' in complex with the catalytic domains, we aim to compare substrate-specificities between Stromelysin-1 (MMP-3), ADAM-9 and ADAM-10, with the aid of molecular dynamics simulations. Our results show that the substrate retains a favourable antiparallel beta-sheet conformation on the P-side in addition to the well-known orientation of the P'-region of the scissile bond, and that the primary substrate selectivity is dominated by the sidechains in the S1' pocket and the S2/S3 region. ADAM-9 has a hydrophobic residue as the central determinant in the S1' pocket, while ADAM-10 has an amphiphilic residue, which suggests a different primary specificity. The S2/S3 pocket is largely hydrophobic in all three enzymes. Inspired by our molecular dynamics calculations and supported by a large body of literature, we propose a novel, hypothetical, catalytic mechanism where the Zn-ion polarizes the oxygens from the catalytic glutamate to form a nucleophile, leading to a tetrahedral oxyanion anhydride transition state.     

Synthesis of 6-Alkyl Carbamato/Alkyl Thiocarbamato-2,10-dichloro-12-trichloromethyl-12 H -dibenzo[d,g][1,3,2]-dioxaphosphocin 6-Oxides

6-Alkylcarbamato/alkylthiocarbamato-2,10-dichloro-12-trichloromethyl-12 H -dibenzo [d,g][1,3,2]-dioxaphosphocin 6-oxides have been synthesized by the condensation of 2,2-bis(2-hydroxy-5-chlorophenyl)-1,1,1-trichloroethane with dichlorophosphinyl carbamates of different alcohols/thiols in the presence of triethylamine in dry toluene and were characterized by different spectral studies.     

Oxathiaphospholane Approach to the Synthesis of Conjugates of Amino Acids Methyl Esters with Nucleosides

Based upon 1,3,2-oxathiaphospholane chemistry, 5'-O-derivatization of nucleosides with the O-methyl esters of amino acids was performed and corresponding conjugates were obtained in satisfactory yield.