新型高精度峰值保持器PKD01在电触头材料电性能模拟试验装置中的应用

介绍了一种高响应速度和高精度的峰值保持器，这种器件采用跨导型运算放大器，同时具有通频带宽、线性好、峰值保持精度高等优点，可快速、准确地检测并保持峰值脉冲信号。文中介绍了PKD01的主要特点，给出了PKD01在电触头材料电性能模拟试验装置的触头熔焊力测量中的应用电路。     

激光光斑有效面积的准确测定

 从激光光斑有效面积的定义出发，采用CCD图像摄取技术，设计了一套激光光斑有效面积测量装置。在4种不同激光光斑能量分布和不同能量密度的情况下，用有效面积测量仪分别进行了实际测试验证。结果表明，该测量装置可以对任何能量非均匀分布的激光光斑的有效面积进行准确测试，有助于提高光学元件激光损伤阈值的测量精度。     

Chromatographic behavior of new deazapurine ribonucleosides in hydrophilic interaction liquid chromatography

The chromatographic behavior of new biogenic purine nucleosides in hydrophilic interaction liquid chromatography was examined on three different stationary phases, namely bare silica, and amide‐ and cyclofructan‐based stationary phases. The effects of buffer concentration, pH and acetonitrile‐to‐aqueous‐part ratio in the mobile phase on retention and peak shape were assessed. The retention coefficients and peak symmetry values substantially differed with respect to analytes´ structures, stationary phase properties and mobile phase composition. The bare silica column was unsuitable for these compounds under the chromatographic conditions tested due to very broad and asymmetrical peaks. Furthermore, the cyclofructan‐based stationary phase provided almost Gaussian peak shapes of all deazapurine nucleosides under most conditions tested. Therefore, the cyclofructan‐based stationary phase is the most suitable choice for the chromatographic analysis of nucleosides.     

一种基于微分法的峰值检测电路

提出了一种基于微分法的峰值检测电路,它包含微分电路、双沿触发比较器和采样保持电路。微分电路对输入信号进行微分变换,双沿触发比较器比较微分变换结果与参考电压,得到采样保持控制信号,以控制采样保持电路的正常工作,实现峰值检测功能。该检测电路具有高频率、高精度的特点,工作频率达到200~500 MHz,峰值检测误差小于5%。该检测电路适用于高速A/D转换器、D/A转换器和具有复杂参数的采集系统等领域。     

Automated peak tracking for comprehensive impurity profiling in orthogonal liquid chromatographic separation using mass spectrometric detection

The presence and quantity of impurities in pharmaceutical drugs can have a significant impact on their quality and safety. With the continuous pressure for increased industry productivity, there is urgent need for a systematic and comprehensive drug impurity profiling strategy. We report here our development of the fully automated Comprehensive Orthogonal Method Evaluation Technology (COMET) system. The system includes five columns, seven orthogonal HPLC methods, and hyphenated UV-MS detections, which provides automated generic impurities screening for any drug sample. An automated MS peak tracking approach by program-based mass spectral interpretation is devised to unambiguously track impurities among all orthogonal HPLC methods. The program passes electro-spray ionization mass spectra (ESI-MS) through four sequential decision-making mass ion tests and determines molecular weights for every peak. The system reduces the time required to obtain impurity profile from weeks to days, while the automated MS peak tracking takes only minutes to interpret all MS spectral data of interest. Up-to-date, impurity contents of 56 in-development drug candidate samples have all been successfully illustrated by COMET, which contained more than 500 chemical entities. The program is able to track more than 80% of the compounds automatically with majority of the failure due to insufficient ionization for some impurities by ESI. This system is well suited for efficient drug development and ensuring the quality and safety of drug products.     

重叠伏安峰的样条卷积法分辨

建立了分辨重叠峰的样条卷积法；利用三阶样条函数构成的峰分辨函数与原信号进行卷积，直接对重叠的伏安峰进行处理，取得了较好的结果；被处理的重叠峰可达到其线分离，且峰位置的相对误差小于3．0％（完全重叠峰为5．4％），峰面积的相对误差小于2．0％；应用于镉（Ⅱ）－铟（Ⅲ）实验体系的微分脉冲伏安信号处理，取得满意的结果。     

18-冠醚-6包结钾离子的毛细管电泳研究

采用毛细管区带电泳前沿分析和峰漂移分析两种方法，以咪唑—醋酸为缓冲溶液，利用间接紫外检测(A=240nm)，测定了18—冠醚—6对钾离子的包结常数；两种方法得到了比较一致的结果；进一步对这两种方法求解结合常数进行了对比和讨论，总结出各自的适用范围。