A General Strategy for Targeting Drugs to Bone

Targeting drugs to their desired site of action can increase their safety and efficacy. Bisphosphonates are prototypical examples of drugs targeted to bone. However, bisphosphonate bone affinity is often considered too strong and cannot be significantly modulated without losing activity on the enzymatic target, farnesyl pyrophosphate synthase (FPPS). Furthermore, bisphosphonate bone affinity comes at the expense of very low and variable oral bioavailability. FPPS inhibitors were developed with a monophosphonate as a bone‐affinity tag that confers moderate affinity to bone, which can furthermore be tuned to the desired level, and the relationship between structure and bone affinity was evaluated by using an NMR‐based bone‐binding assay. The concept of targeting drugs to bone with moderate affinity, while retaining oral bioavailability, has broad application to a variety of other bone‐targeted drugs.     

Passively Q-switched self-frequency doubling Nd:Ca4GdO(BO3)3 laser with Cr:YAG saturable absorber

Nd³⁺ : Ca₄GdO(BO₃)₃, known as Nd : GdCOB, is a new self-frequency doubling laser crystal. Using Cr⁴⁺ : YAG as passive Q-switch, we have realized the Q-switched laser running at 0.53 μm with an Nd : GdCOB crystal. Meanwhile, the pulse width, the single pulse energy and the repetition rate under different small-signal transmission of Cr⁴⁺ : YAG and different pump conditions are measured and the numerical solutions of the coupling wave rate equations agree with the experimental results.     

Q-switching of a diode-pumped Nd : YVO4 laser with GaAs nonlinear output coupler

Passive Q-switching of a diode-pumped Nd : YVO₄ laser was demonstrated using GaAs as an output coupler and as a saturable absorber. When pumped with a 3-W diode laser at 809 nm, the highly compact laser produced 12-μJ pulses of 2.2 ns in duration at 1.064 μm in a single transverse mode, corresponding to a peak power of 5.6 kW.     

在s~(1/2)=4.03GeV的e~+e~-湮没中D_s~+单标记的研究及D_s~+D_s~-对产生截面的测定

利用北京正负电子对撞机 (BEPC)和北京谱仪 (BES) ,基于在质心系能量s=4.0 3GeV的e+ e-湮没中 ,D+ s 单标记的分析结果 ,测定了D+ s →K 0 K+ 和D+ s →K0 K+ 衰变的分支比。其结果Br(D+ s →K 0 K+ ) =(3.0 2± 0 .94±0 .91) % ,Br(D+ s →K0 K+ ) =(3.2 8± 1.2 2± 0 .94) %与世界平均值在误差范围内一致 .用π+ ,K 0 K+ ,K0 K+ 作为单标记 ,共观测到 94± 13个D+ s 事例 ,测得在e+ e-湮没中D+ s D-s 对产生的截面为σprodD+s D-s =45 1± 6 3± 118pb .     

Franco-Russian comparison of mixed neutron and gamma radiation field dosimeters at the Silène reactor

This paper gives the results of dosimetry measurements carried out in the Silène reactor at Valduc (France) with neutron and photon dosimeters in mixed neutron and gamma radiation fields, in the frame of a Franco-Russian comparison of dosimeters. Neutron dosimetry was supplied by passive semiconductors, activation detectors and nuclear track detectors. For photon dosimetry, thermoluminescent and passive semiconductor detectors were used. The experiments were located at 3 m from the reactor core, in free air and also at the front and back of a tissue-equivalent phantom. The pulse operating mode of the reactor was used to simulate a criticality accident with solid fissile material, while the free evolution mode simulated a criticality accident in a fissile solution. The photon absorbed dose showed a slight increase on entering the phantom compared to measurements in free air, probably due to backscattering by the phantom. At the rear of the phantom, the neutron kerma was four times lower than on the front, whereas the photon dose was only two times lower. The heterogeneity of dose inside the phantom was far greater for neutrons than for photons.     

Passive control of wake flow by two small control cylinders at Reynolds number 80

Passive control of the wake behind a circular cylinder in uniform flow is studied by numerical simulation at Re_D=80. Two small control cylinders are placed symmetrically along the separating shear layers at various stream locations. In the present study, the detailed flow mechanisms that lead to a significant reduction in the fluctuating lift but maintain the shedding vortex street are clearly revealed. When the stream locations lie within 0.8≤X_C/D≤3.0, the alternate shedding vortex street remains behind the control cylinders. In this case, the symmetric standing eddies immediately behind the main cylinder and the downstream delay of the shedding vortex street are the two primary mechanisms that lead to a 70–80% reduction of the fluctuating lift on the main cylinder. Furthermore, the total drag of all the cylinders still has a maximum 5% reduction. This benefit is primarily attributed to the significant reduction of the pressure drag on the main cylinder. Within X_C/D>3.0, the symmetry of the standing eddy breaks down and the staggered vortex street is similar to that behind a single cylinder at the same Reynolds number. In the latter case, the mean pressure drag and the fluctuating lift coefficients on the main cylinder will recover to the values of a single cylinder.     

DNS of a spatially developing turbulent boundary layer with passive scalar transport

A direct numerical simulation (DNS) of a spatially developing turbulent boundary layer over a flat plate under zero pressure gradient (ZPG) has been carried out. The evolution of several passive scalars with both isoscalar and isoflux wall boundary condition are computed during the simulation. The Navier–Stokes equations as well as the scalar transport equation are solved using a fully spectral method. The highest Reynolds number based on the free-stream velocity U_∞ and momentum thickness θ is Re_θ=830, and the molecular Prandtl numbers are 0.2, 0.71 and 2. To the authors’ knowledge, this Reynolds number is to date the highest with such a variety of scalars. A large number of turbulence statistics for both flow and scalar fields are obtained and compared when possible to existing experimental and numerical simulations at comparable Reynolds number. The main focus of the present paper is on the statistical behaviour of the scalars in the outer region of the boundary layer, distinctly different from the channel-flow simulations. Agreements as well as discrepancies are discussed while the influence of the molecular Prandtl number and wall boundary conditions is also highlighted. A Pr scaling for various quantities is proposed in outer scalings. In addition, spanwise two-point correlation and instantaneous fields are employed to investigate the near-wall streak spacing and the coherence between the velocity and the scalar fields. Probability density functions (PDF) and joint probability density functions (JPDF) are shown to identify the intermittency both near the wall and in the outer region of the boundary layer. The present simulation data will be available online for the research community.     

被动传感器阵列中基于粒子滤波的目标跟踪

针对被动传感器阵列中的机动目标跟踪问题,该文提出了一种基于多模Rao-Blackwellized粒子滤波的机动目标跟踪新方法。算法首先基于Rao-Blackwellization理论将机动目标跟踪问题划分为模型选择和目标跟踪两个子问题;采用多模Rao-Blackwellized粒子滤波对目标运动模型进行选择,扩展Kalman滤波对目标进行更新,有效降低了抽样粒子状态维数,节省了计算时间;最后,建立了被动传感器阵列的非线性观测模型。实验结果表明,提出方法可以有效地对目标模型进行选择,算法的跟踪性能及稳定性要好于交互多模型(IMM)方法。     

Numerical evaluation of passive control of shock wave/boundary layer interaction on NACA0012 airfoil using jagged wall

Shock formation due to flow compressibility and its interaction with boundary layers has adverse effects on aerodynamic characteristics, such as drag increase and flow separation. The objective of this paper is to appraise the prac-ticability of weakening shock waves and, hence, reducing the wave drag in transonic flight regime using a two-dimensional jagged wall and thereby to gain an appropriate jagged wall shape for future empirical study. Different shapes of the jagged wall, including rectangular, circular, and triangular shapes, were employed. The numerical method was validated by experimental and numerical studies involving transonic flow over the NACA0012 airfoil, and the results presented here closely match previous experimental and numerical results. The impact of parameters, including shape and the length-to-spacing ratio of a jagged wall, was studied on aerodynamic forces and flow field. The results revealed that applying a jagged wall method on the upper surface of an airfoil changes the shock structure significantly and disinte-grates it, which in turn leads to a decrease in wave drag. It was also found that the maximum drag coefficient decrease of around 17%occurs with a triangular shape, while the max-imum increase in aerodynamic efficiency (lift-to-drag ratio) of around 10%happens with a rectangular shape at an angle of attack of 2.26?.     

Single-walled carbon nanotubes on side polished fiber as a universal saturable absorber for various laser output states

We demonstrated four different laser operational states in the same passive fiber ring laser cavity by controlling solely the polarization state in a saturable absorber. The demonstrated laser operational states were continuous wave, mode-locking, Q-switching, and Q-switched mode-locking. The saturable absorber was fabricated by spin-coating a single-walled carbon nanotubes (SWCNT)/polymer composite on a side polished fiber providing enhanced nonlinear interaction with the SWCNT. The wide tuning range of the saturable absorber allows the simple means to generate different forms of laser output from a single laser cavity.