Hapten immobilization for antibody sensing using a dynamic modification protocol

Optical fiber (OF) sensors are often limited by the immobilization technique used to associate a specific sensing ligand with the OF surface. This is particularly true when the ligand is biologically active as, for example, in the case of immobilized haptens or antibodies. The dynamic modification protocol is a regenerable and experimentally simple way to immobilize a variety of sensing molecules on an OF surface. Furthermore, the protocol is immune to hydrolysis and not limited by diffusion through a membrane or sol–gel. In this publication the approach is extended by immobilizing the hydrophobic hapten (octadecyl 6-(2,4 dinitrophenyl)aminohexanoic acid) as a means to prepare an OF sensor for antibodies specific for 2,4 dinitrophenyl (DNP). The LOD for anti-DNP is 0.5 nanomolar and the K_apparent is 1.0±0.2×10⁶. Nonspecific antibody adsorption is problematic in this sensing approach and was found to limit the quantitative capabilities of the sensor. However, time discrimination can be used to allow the nonspecific antibody to desorb prior to measurement thus minimizing the influence of nonspecific binding on sensor performance.     

能动抛光磨盘的变形实验研究

 能动抛光磨盘实时产生不同的表面变形，在对大口径非球面光学元件进行精磨和抛光时实现与工件表面良好的大尺寸吻合，可以消除传统光学加工采用小尺寸磨头时带来的高频残余误差并提高加工效率。以加工直径1.3m左右，F/2的抛物面光学元件为例，对能动磨盘在不同离轴度时能够产生的变形进行了计算和实验。结果表明，能动磨盘能够以较高精度产生旋转对称或非对称的抛物面形状。对能动磨盘产生变形后的残余误差进行了分析。     

腔长失调对光腔衰荡法测量精度的影响

 只考虑腔长失调因素下建立了反射率模拟测量的理论模型。根据高斯光束传输规律分析了腔长失调对衰荡腔模式耦合的影响，推导了腔长失调与谐振腔输出脉冲信号、衰荡信号与反射率之间的关系，模拟了腔长失调在±10mm范围内的光脉冲衰荡现象。结果表明：对于光敏面直径为0.2mm的高速探测器，为了保证10^-6的测量精度，腔长的失调量应控制在±1mm之间。在光路调节中采用具有对数变换功能的示波器和动态范围较大的探测器，可以提高测量精度。     

高能闪光照相中影响光程确定的几个因素

 利用闪光照相基本原理和成像原理，在直接记录法和转换屏记录法的情况下，研究了闪光照相中影响X射线在材料中光程确定的主要因素。结果表明，影响光程确定的几个因素是：散射效应、光源角分布效应、立体角效应和能谱效应。对于高能闪光照相，散射效应是影响光程确定的最主要因素，散射的存在使光程的测量值比实际值降低20%～40%。因此必须在做CT之前，对散射的影响进行修正。     

神光-Ⅱ装置三倍频实验中靶场单元技术的改进

 主要介绍为了满足神光-Ⅱ高功率激光装置三倍频光（351nm，3ω）的物理实验要求，靶场三倍频模拟光源和瞄准监视系统两个主要单元技术的改进，即三倍频模拟光源由基频光（1 053nm，3ω）通过腔外的KTP+BBO晶体倍频获得，再经八路分光系统和主激光耦合；瞄准监视系统由透射式光学系统改进为反射式光学系统，避免原系统存在较大的色差，提高瞄准精度。     

新型光纤激光雷达的结构理论分析与作用距离计算

为了改善当前激光雷达存在的对振动敏感,体积庞大,对人眼不安全等问题,综合国内外激光雷达研究现状的基础上.给出了一种新型光纤激光雷达的结构.该雷达利用光纤激光器作为光源,光路中大量采用了光纤器件,使得系统体积大大减小.采用相干探测的原理,根据激光雷达作用距离方程,给出了信噪比与光纤激光雷达作用距离的关系.根据所选的器件参数,通过理论计算,在探测概率为0.9,虚警概率小于10-4的情况下,得到了2 km的最大作用距离.所设计的光纤激光雷达体积小,结构紧凑、新颖,具有良好的探测能力.     

Balancing CapEx reduction and network stability with stable routing–virtual topology capacity adjustment (SR–VTCA)

This paper investigates the merits of the SR–VTCA (stable routing–virtual topology capacity adjustment) approach as a mechanism to find a beneficial trade-off between network stability and reduction in capital expenditures (CapEx). These are two main objectives for the entities that own the optical infrastructure, such as network operators (NOs), and those also acting as Internet service providers (ISPs). The SR–VTCA scheme is a novel approach to adapt transparent optical networks to time-varying traffic by adjusting the number of lightpaths between node pairs, while keeping the IP routing unchanged. Lightpath bundling (LB) and anycast (AS) switching are combined in SR–VTCA operation to advertise lightpath additions/removals to the IP layer as mere adjustments (increments or decrements) in the capacity, allowing to keep the IP routing stable, and thus, simplifying control plane operations. On the contrary, a fully-reconfigurable (FR) network design, where IP routing can be also modified, would increase the burden in the control plane, but at a higher CapEx reduction, since the optical infrastructure is used more efficiently. In this work, we investigate the CapEx overprovision introduced by SR–VTCA with respect to a FR scheme. In order to do this, SR–VTCA planning problem is first modeled as a MILP formulation. A heuristic procedure based on traffic domination is then proposed to solve large instances of the problem. Exhaustive experiments are conducted comparing the SR–VTCA solutions obtained by the aforementioned MILP and heuristic proposal with solutions found by other optimization methods presented in the literature to solve the FR planning problem. Finally, the results show that SR–VTCA can achieve similar results to the FR case in terms of CapEx reduction, while a huge number of IP reroutings are saved by maintaining IP stability. Thus, SR–VTCA provides an advantageous balance between CapEx overprovisioning and the control plane overhead associated with IP rerouting.     

MPNIM结构光致变电容效应

本文报告了作者之一首先发现的MPNIM(金属-P型半导体-N型半月比-绝缘体-金属)结构的光致变电容效应。基于该效应已研制出新器件:半导体双向光控变容器.新器件的电容值与入射光强的关系,光谱响应特性,频率特性,C-V特性,温度特性已被研究.     

2.5Gb/s光外调制器及驱动器

文章对光外调制作了原理及实验上的分析,着重研究作为驱动器的大功率宽带放大器。对２．５Ｇｂ／ｓＮＲＺ伪随机码对放大器的低端截止频率和高端截止频率的要求进行了理论分析。提出并实验了几种放大器高频补偿技术,取得了好的效果。为满足输入输出阻抗为５０Ω的要求采用了共面波导计算方法,以确定印刷电路板导线尺寸。最后对光外调制器输出波形进行了测试。     

高分辨率显示屏特性分析用光学透镜设计

描述了高分率显示屏特性分析用的光学透镜的特点和设计要求。分析了调焦镜头和镜头位置调节两种结构的优缺点，推导了屏厚变化（即物距变化）对测量精度影响的表达式。给出了设计实例。实验测量结果与理论分析基本上一致。