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The reaction conditions employed directed the site of functionalisation of ketones with NBS: under solvent-free conditions α-bromination was the exclusive process, while in water, ring functionalisation occurred in the case of methoxy substituted aromatic ketones. 相似文献
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《Tetrahedron letters》2019,60(27):1788-1791
An expedient, mild and environmentally benign method for the oxidation of styrenes to α-hydroxy ketones has been developed. This conversion has been achieved by employing water as a solvent as well as an oxygen source. This facile and efficient tandem process provides α-hydroxy ketones in moderate to good yields from easily accessible styrenes. 相似文献
65.
An efficient synthetic route towards the synthesis of β-keto sulfones has been developed from secondary benzyl alcohols using N-bromosuccinimide (NBS). The present protocol utilizes NBS as oxidant as well as brominating agent, readily accessible benzyl alcohols and sodium arenesulfinates as the sulfonylating reagent under mild conditions. The control experiments revealed that the reaction proceeds via oxidation of alcohol to ketone, α-bromination of ketone and nucleophilic substitution by sodium arenesulfinate. Furthermore, the efficiency of the methodology was tested with a gram scale reaction and also shown the synthetic utility. 相似文献
66.
Abdellatif M. Salaheldin Ana M.F. Oliveira-Campos Lígia M. Rodrigues 《Tetrahedron letters》2007,48(50):8819-8822
Treatment of 5-amino-4-cyanopyrazoles with N-bromosuccinimide, in DMF at rt gave azo dyes resulting from dimerization through the amino groups and further oxidation.With bromine water the dimer was also formed but, bromination occurred on the aryl ring, either at reflux or rt. Reduction of the azo group with zinc in acetic acid originated the corresponding pyrazoles. 相似文献
67.
Long V. Dinh 《Journal of organometallic chemistry》2005,690(2):493-503
Reactions of diazocyclopentadiene and NBS at appropriate stoichiometries give 2,5-dibromodiazocyclopentadiene and 2,3,5-tribromodiazocyclopentadiene in 40% and 30% yields, respectively, after chromatography. These react with BrRe(CO)5 or BrMn(CO)5 (80 °C, CF3C6H5) to give (η5-1,2,3-C5H2Br3)M(CO)3 (3; M = a, Re; b, Mn) and (η5-C5HBr4)M(CO)3 (4a,b) in 75-85% yields. In the case of 4a, the intermediate η1-cyclopentadienyl complex (η1-C5HBr4)Re(CO)5 (4′a) can be isolated (44%). An isomer of 3b, (η5-1,2,4-C5H2Br3)Mn(CO)3, is accessed by desilylating previously reported (η5-1,2,4-C5(SiMe3)2Br3)Mn(CO)3 with CsF/MeOH (85%). The reaction of tetrabromodiazocyclopentadiene and BrRe(CO)5 at 80 °C in CF3C6H5 gives the η1-cyclopentadienyl complex (η1-C5Br5)Re(CO)5 (5′a, 74%) which cannot be induced to decarbonylate to (η5-C5Br5)Re(CO)3 (5a) under a variety of conditions. However, 5a can be isolated (45%) when a similar reaction is conducted at 120 °C. The IR properties of the preceding complexes are compared, and the crystal structures of 3a, 3b, 5a, and 5′a are determined and analyzed. 相似文献
68.
Two highly sensitive chemiluminescence (CL) systems are described. The method is based on the CL generated during the oxidation of luminol by N-bromosuccinimide (NBS) and N-chlorosuccinimide (NCS) in alkaline medium. The emission intensity is reduced by the presence of some surfactants at concentrations lower than critical micelle concentration (cmc).A new, simple, rapid and selective flow injection CL method for the determination of cationic surfactants such as dodecyltrimethylammonium bromide (DTAB), cetyltrimethylammonium bromide (CTAB) and cetylpyridinium chloride (CPC) is proposed. Their determinations are based on the reducing effect on the emission intensity of NBS-luminol and NCS-luminol chemiluminescent reactions. The effect of analytical and flow injection analysis (FIA) variables on these CL systems and on the determination of the cationic surfactants are discussed. The optimum parameters for the determination of cationic surfactants were studied and were found to be the following: luminol, 1×10−6 M; NBS and NCS both, 5×10−2 M; NaOH, 5×10−2 M and flow rate, 3.5 ml min−1. 相似文献
69.
Metal triflate catalyzed 1,2-bromoazidation of alkenes was performed using N-bromosuccinimide (NBS) and trimethylsilyl azide (TMSN3) as the bromine and azide sources, respectively. Among the metal triflates, Zn(OTf)2 was found to be the best catalyst. This catalytic process represents a highly regioselective, stereoselective and high yielding method for the synthesis of anti-1,2-bromoazides from a variety of alkenes including α,β-unsaturated carbonyl compounds. 相似文献
70.
Ana Flávia Borsoi Mateus Emanuel Coldeira Kenia Pissinate Fernanda Souza Macchi Luiz Augusto Basso 《合成通讯》2017,47(14):1319-1325
A ultrasound-assisted oxidative cyclization of semicarbazones using N-bromosuccinimide in the presence of sodium acetate was established providing efficient and rapid access to a variety of 2-amino-1,3,4-oxadiazoles. Moreover, the new synthetic protocol provides a simple procedure utilizing a safer oxidizing system that affords the target products in high regioselectivity, satisfactory yields, and elevated purities. 相似文献