Chlorogenic Acid-Loaded Mesoporous Silica Nanoparticles Modified with Hexa-Histidine Peptides Reduce Skin Allergies by Capturing Nickel

Nickel-induced contact dermatitis is a severe allergic reaction to objects or environments that contain nickel. Many nanomaterials have been developed to reduce skin allergies by capturing nickel, but few agents are effective and safe. In this work, mesoporous silica nanoparticles (MSN) were synthesized and decorated with hexa-histidine peptides (denoted as MSN-His⁶), making it a strong nickel chelator. Subsequently, a dietary polyphenol, chlorogenic acid, was loaded into the mesopores of MSN (denoted as MSN-His⁶@CGA), realizing the potential of its anti-inflammatory properties. In vitro and in vivo experiments revealed that the synthesized MSN-His⁶@CGA nanoparticles exhibited more stable and stronger chelation, better biocompatibility, and ideal allergy-relieving ability, whether for environmental metal contamination or for allergic contact dermatitis caused by prolonged nickel exposure. Thus, the application of mesoporous silica-based nanoparticles may represent an ideal approach to alleviate skin allergies by capturing nickel, which would benefit people who suffer from metal-induced contact dermatitis.     

网络信息监控中的MSN Messenger行为模式发现

为了解用户在网络上的行为，网络协议分析和网络行为模式发现是网络监测监控的基本内容之一。本文在阐述了网络行为模式发现的基本方法和实现原理的基础上，以MSN Messenger协议为例，根据捕获的数据包，分析其中有关登录和退出的具体协议内容，找出了此行为模式的特征，据此可以实时发现用户的MSN Messenger行为。本方法已经在实际系统中得到应用。     

关于对MSN文件传输特点及其还原的研究

MSN作为时下国内外都比较流行的一款即时通信软件,拥有比较广泛的用户群。探讨了即时通信软件MSN在文件传输时的特点,重点对MSN传输特定格式文件时的特征给予了分析和研究,针对诸如PDF与PPT等文件格式的文件在明文传输时,因其在文件首部会有特定文件结构特征串,从而可以根据这一特点确定MSN有传输文件的行为。并在基于特定文件格式特征串对MSN传输的文件实现了数据还原,旨在为数据恢复提供新的研究思路。     

自相似环流网状网性能分析

文章对自相似环流网状网的路由协议做了研究,提出了两种选路算法,并且对自相似环流网状网的性能指标(阻塞率与时延)做了仿真分析,并将仿真结果与根据Manhattan网络模型得到的结果做了对比和分析.结果表明我们的模型比曼哈顿街区网(MSN)模型更适合于光分组交换网络.     

Antifouling zwitterionic pSBMA‐MSN particles for biomedical applications

Mesoporous silica nanoparticles (MSNs) are one of the most promising nanocarriers in biomedicine. Nonetheless, surface modification has been pointed out as a condition necessary for drug delivery applications, where stability and biocompatibility are extremely important for the vehicle performance. Likewise, zwitterionic polymers are outstanding candidates in biological fields, where poly(sulfobetaine methacrylate) (pSBMA) has been widely studied. These polymers, known as antifouling materials, are able to render a surface capacity to avoid protein adhesion. In this work, a core‐shell nanocarrier was created, where pSBMA was covalently grafted by atom transfer radical polymerization (ATRP) onto a previously functionalized MSN surface. Brush morphologies with different chain lengths ( , between 6500 and 32 300) and graft densities (σ_pSBMA, between 0.15 and 0.51 molecules of pSBMA per nm² of MSN) were obtained. Protein adhesion resistance was evaluated with two proteins: fibronectin (FN) and bovine serum albumin (BSA). The best nanocarrier synthesized allowed a reduction of 96% of FN and 76% of BSA adhesion (compared with an adsorption of 100% assigned to the native material). Since the influence of the brush morphology is seldom studied or reported, this work aims to comprehend how the configuration of the polymer brushes affected their antifouling capacity, in order to use this pSBMA‐MSN product for biomedical applications, notably as a possible drug delivery nanocarrier. Future work will analyze the solution behavior of the zwitterionic brushes to evaluate variations of temperature and pH values as possible mechanisms of delivery.