Computer based screening of compound databases: 1. Preselection of benzamidine-based thrombin inhibitors

We present a computational protocol which uses the known three-dimensional structure of a target enzyme to identify possible ligands from databases of compounds with low molecular weight. This is accomplished by first mapping the essential interactions in the binding site with the program GRID. The resulting regions of favorable interaction between target and ligand are translated into a database query, and with UNITY a flexible 3D database search is performed. The feasibility of this approach is calibrated with thrombin as the target. Our results show that the resulting hit lists are enriched with thrombin inhibitors compared to the total database.     

一种具有O信息复杂度的高速crossbar调度算法

本文提出一种可扩展性强的高速crossbar调度算法——iRGRR(iterative request-grant-based round-robin),它通过简化处理流程和减小调度开销,克服了传统算法(例如iSLIP^[1]、PIM^[2])可扩展性差的缺陷.iRGRR将控制信息复杂度从O(N)级大大减小到O(logN)级,具有良好的可扩展性,可应用于太比特交换机/路由器中.仿真结果表明,在各种不同的均匀和非均匀业务流下,iRGRR能够获得与iSLIP几乎相同的性能.另外,iRGRR比iSLIP具有更好的公平性以及更加易于用硬件实现.     

准数字示样DRFM对线性调频脉压雷达的干扰和仿真

传统的干扰信号通过线性调频雷达脉冲压缩处理后,能量损失严重,不能很好的完成干扰的任务.本文简述了DRFM的原理、分类和优缺点,提出准数字示样DRFM的干扰方式,分析这种方式对线性调频脉压雷达干扰的有效性并对此进行仿真.     

图像通信业务的现状与发展方向

阐述了图像通信的业务涵盖范围及其技术发展现状，简要介绍了图像通信的发展方向，指出了图像通信产业发展面临的研究课题。     

IP网端到端性能测量技术研究的进展

本文介绍了Internet端到端测量技术的最新进展,包括性能拓扑推测、时延测量、丢包率测量.最后讨论了未来Internet端到端测量的研究趋势和应用前景.     

快速分形图像编码的一种特征方法

快速分形图像编码的特征向量法是最具创新性、最有前途的方法之一,但它有几个缺点、特别是特征向量的高维数性.针对这个问题,本文提出减少分形编码时间的一种可选的特征方法.作为它的应用,本文先定义图像块的新特征——叉迹,然后提出一个基于叉迹的快速分形算法.这个算法把Range-Domain子块匹配问题转化为叉迹意义下的邻域搜索问题.对256×256 Lena图像的实验显示,与基于全搜索的基本分形算法比较,依赖于搜索邻域大小,该算法既能在峰值信噪比相同的情况下实现加快3倍多,也能在主观质量有一定下降的成本下实现加快100倍以上.     

Versatile cobalt complexes for initiating immortal ring‐opening polymerization (ROP) of lactide (LA), mediating living radical polymerization of t‐butyl acrylate (tBA) and catalyzing copolymerization of LA and tBA by combination of ROP and organometallic‐mediated radical polymerization

Low‐cost, highly active and versatile amino‐bis(phenolate) cobalt complexes are developed. The cobalt complexes can control living polymerization of different categories of monomers including lactide (LA) by immortal ring‐opening polymerization in argon and even in air and acrylate via living radical polymerization (LRP). The cobalt‐based catalysts were used for copolymerization of LA and acrylate. The immortal polymerization of LA using the cobalt complexes as initiators proceeds in argon and even in air and without the requirement for extensive drying techniques or inert atmosphere whilst retaining end‐group fidelity. The cobalt complexes are used to mediate LRP of t‐butyl acrylate (tBA) in methanol. The block copolymerization of LA and tBA catalyzed by single‐site cobalt organometallic catalyst is also reported for the first time. This cobalt system offers a versatile and green way to produce homopolymers and block copolymers.     

Reverse fragment based drug discovery approach via simple estimation of fragment contributions

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