Biological generation of tritiated vitamin D3 metabolites and their purification by high-performance liquid chromatography

Summary A simple, reproducible method for the biological synthesis of tritiated 24,25-dihydroxycholecalciferol, 25,26-dihydroxycholecalciferol and 1,25-dihydroxycholecalciferol is described. Kidney homogenates from both vitamin D deficient and replete chicks were usedin vitro to generate these dihydroxylated metabolites using 25 (23,24-³H) hydroxycholecalciferol as the substrate. Tritiated products were purified by Sephadex LH 20 chromatography followed by high-performance liquid chromatography; the identity of each metabolite was established by chromatography with authentic crystalline preparations.Presented at the Symposium organised by the Chromatography Discussion Group, held at Hatfield Lodge on 29 November 1979.     

Symmetrische Permutationsmengen

A permutation set (M, I) consisting of a setM and a set of permutations ofM, is calledsymmetric, if for any two permutations, the existence of anx M with (x) (x) and ^–1 (x) = ^–1 (x) implies ^–1 = ^–1 , andsharply 3-transitive, if for any two triples (x ₁,x ₂,x ₃), (y ₁,y ₂,y ₃) M ³ with|{x ₁,x ₂,x ₃ }| = |{y ₁,y ₂,y ₃ }| = 3 there is exactly one permutation with(x ₁) =y ₁,(x ₂) =y ₂,(x ₃) =y ₃. The following theorem will be proved.THEOREM.Let (M, ) be a sharply 3-transitive symmetric permutation set with |M|3, such that contains the identity. Then is a group and there is a commutative field K such that and the projective linear group PGL(2, K) are isomorphic.     

Linear combination of concomitants of order statistics with application to testing and estimation

Summary Let (X ₁,Y ₁), (X ₂,Y ₂),…, (X _n,Y _n) be i.i.d. as (X, Y). TheY-variate paired with therth orderedX-variateX _rn is denoted byY _rn and terms the concomitant of therth order statistic. Statistics of the form are considered. The asymptotic normality ofT _n is established. The asymptotic results are used to test univariate and bivariate normality, to test independence and linearity ofX andY, and to estimate regression coefficient based on complete and censored samples.     

KT-nearfields of rank 2

Summary Nearfields of rank 2 over their kernel which are not Dickson nearfields have recently been constructed by H. Zassenhaus. Here it is shown that KT-nearfields of rank 2 over their kernels and of characteristic 2 are necessarily Dickson nearfields which are coupled to quadratic field extensions and their Dickson group is isomorphic to ₂. Using results of Gröger one obtains all KT-nearfields of rank 2 over the field of rational numbers.     

Quadratically constrained least squares and quadratic problems

Summary We consider the following problem: Compute a vectorx such that Ax–b₂=min, subject to the constraint x₂=. A new approach to this problem based on Gauss quadrature is given. The method is especially well suited when the dimensions ofA are large and the matrix is sparse.It is also possible to extend this technique to a constrained quadratic form: For a symmetric matrixA we consider the minimization ofx ^T A x–2b ^T x subject to the constraint x₂=.Some numerical examples are given.This work was in part supported by the National Science Foundation under Grant DCR-8412314 and by the National Institute of Standards and Technology under Grant 60NANB9D0908.     

Differential calculus on quantized simple lie groups

Differential calculi, generalizations of Woronowicz's four-dimensional calculus on SU _q (2), are introduced for quantized classical simple Lie groups in a constructive way. For this purpose, the approach of Faddeev and his collaborators to quantum groups was used. An equivalence of Woronowicz's enveloping algebra generated by the dual space to the left-invariant differential forms and the corresponding quantized universal enveloping algebra, is obtained for our differential calculi. Real forms for q are also discussed.     

Functional inequality characterizing nonnegative concave functions in (0, ∞) k

Summary In the present note we prove that every functionf: (0, ) [0, ) satisfying the inequalityaf(s) + bf(t) f(as + bt), s, t > 0, for somea andb such that 0 <a < 1 <a + b must be of the formf(t) = f(1)t, (t > 0). This improves our recent result in [2], where the inequality is assumed to hold for alls, t 0, and gives a positive answer to the question raised there.An analogue for functions of several real variables of the above result characterizes concave functions. Conjugate functions and some relations to Hölder's and Minkowski's inequalities are mentioned.     

Bootstrap,wild bootstrap,and asymptotic normality

Summary We show for an i.i.d. sample that bootstrap estimates consistently the distribution of a linear statistic if and only if the normal approximation with estimated variance works. An asymptotic approach is used where everything may depend onn. The result is extended to the case of independent, but not necessarily identically distributed random variables. Furthermore it is shown that wild bootstrap works under the same conditions as bootstrap.This work has been supported by the Deutsche Forschungsgemeinschaft, Sonderforschungsbereich 123 Stochastische Mathematische Modelle     

Problème inverse de la théorie du potentiel logarithmique pour les lemniscates

The paper is related to the question of uniqueness in the inverse logarithmic potential problem. This question is to find the conditions on which two domains D ₁ and D ₂ producing the same external potential must coincide. Assuming the general hypothesis of regularity and an additional condition of connectivity of (D₁D₂)_c, we prove a theorem of uniqueness in the case when one of the domains is a lemniscate. The main tool is one lemma for Cauchy's potential due to M. Sakai. We give a simple proof of its extension to Newtonian potential.

     

Factorial regular representation of groups in complete graphs

A necessary and sufficient condition for the group of isomorphisms involved in a factorization of a complete graph into isomorphic factors is established.