In vitro study of ferromagnetic stents for implant assisted-magnetic drug targeting

Implant-assisted-magnetic drug targeting (IA-MDT) was studied in vitro using a coiled ferromagnetic wire stent made from stainless steel 430 or 304, and magnetic drug carrier particle (MDCP) surrogates composed of poly(styrene/divinylbenzene) embedded with 20 wt% magnetite. The fluid velocity, particle concentration, magnetic field strength, and stent material all proved to be important for capturing the MDCP surrogates. Overall, this in vitro study further confirmed the important role of the ferromagnetic implant for attracting and retaining MDCPs at the target zone.     

Modeling of magnetic bandages for drug targeting: Button vs. Halbach arrays

Magnetic targeting of drugs to diseased tissues, such as non-healing wounds or skin tumors, is a promising clinical use of magnetic microspheres. For successful magnetic targeting, a magnet must be placed in close proximity to the target tissue. In this work the forces exerted on magnetic microspheres by different arrangements of magnets including a simple square magnet, a number of button magnet arrays, and a Halbach array were simulated and compared. Magnetic bandages utilizing a Halbach array configuration were found to yield the best trapping characteristics (large and uniform force distributions) for magnetic targeting applications close to a surface.     

In vitro investigation of the behaviour of magnetic particles by a circulating artery model

Magnetic drug targeting is the use of coated magnetic nanoparticles as carriers for cytostatic drugs. After intraarterial application of these carriers, they are attracted with an external magnetic field to, for example, an experimental VX2 tumour. The biological compatibility of this system depends on several physiological and physical parameters. We established an in vitro model to simulate in vivo conditions in a circulating system consisting of a circuit with an intact bovine femoral artery close to an external magnetic field. Nanoparticle suspensions were applied by a side inlet. After the magnetisation procedure particle size, concentration and distribution was examined.     

连续混沌系统的非线性自适应预测跟踪控制

基于混沌时间序列的非线性自适应预测原理,用一种sigmoid-Volterra自适应预测滤波器研究了连续混沌系统的非线性自适应预测跟踪控制.通过对Lorenz,R?ssler等典型混沌系统的控制,仿真证实了这种sigmoid-Volterra自适应预测控制器的有效性.这种方法的优点在于它既不需要知道精确的混沌系统模型,也不需要进行系统模型辨识. 关键词： 混沌 sigmoid-Volterra自适应预测滤波器 非线性自适应预测跟踪     

Polypyrrole Nanospheres with Magnetic and Cell‐Targeting Capabilities

The preparation of polypyrrole/Fe₃O₄ nanospheres by a facile mini‐emulsion polymerization method is investigated using poly(ethylene glycol), poly(ethylene oxide), poly(vinyl alcohol), and hyaluronic acid as surfactants. Hyaluronic acid is deemed the most suitable surfactant since it results in well‐dispersed nanospheres of 80–100 nm, and offers the advantages of biocompatibility, cell adhesive property, and the availability of functional groups for attachment of other molecules. These polypyrrole/Fe₃O₄ nanospheres are magnetic and can be further functionalized with a cancer antibody, herceptin. Our results show that this combination of hyaluronic acid and herceptin results in high specific uptake of the nanospheres by cancer cells.