卫星宽带互联接入

卫星宽带互联技术是当今卫星通信领域的技术发展方向。作为地面有线网络的重要补充 ,卫星宽带接入技术具有其独特的应用特点和应用环境。根据卫星通信的特点 ,卫星链路的传输质量和信道延时是卫星宽带接入应用时 ,必须考虑和解决的问题。目前国际卫星通信市场上 ,美国的休斯公司和以色列的吉莱特公司已开发出了相应的宽带接入产品 ,如 :DirecPC ,Sky blaster,Direcway。     

Satellite broadcasting: System concepts and the television transmission standards for europe

Within Western Europe several countries have indicated their intention to start DBS services in the 12 GHz band in 1985/6 or soon after. Against this background the European Broadcasting Union has recommended a common transmission standard known as C-MAC/packet. An outline is given of the system, with a discussion of the requirements for a broadcasting satellite and receivers for individual reception.     

基于DSP的铝电磁铸造磁场控制器的设计和实现

阐明电磁半连续铸造对铝合金生产的重要性,介绍了基于此特殊复合电磁场的性能要求研制的控制系统。系统以双核（DSP为控制核心,单片机作为专用人机接口控制核心）加CPLD的总体架构,使用新的高频双窄脉冲列的晶闸管触发方式。分析了系统的主要硬件结构、μc／OS-II软件编写,并给出了部分功能实现的波形。经测试,系统达到要求,控制精度高、动态性能好。     

光栅式自由立体显示器概述

文章介绍了光栅式自由立体显示器的结构及原理,分析了影响其立体效果及性能的因素,如人眼调节和会聚特性、多视点技术、亮度及分辨率损失、串扰、2D／3D切换及兼容性等,并简要介绍了相应的提高立体显示效果的方法。     

The Evolving Role of Microsampling in Therapeutic Drug Monitoring of Monoclonal Antibodies in Inflammatory Diseases

Monoclonal antibodies (mAbs) have been extensively developed over the past few years, for the treatment of various inflammatory diseases. They are large molecules characterized by complex pharmacokinetic and pharmacodynamic properties. Therapeutic drug monitoring (TDM) is routinely implemented in the therapy with mAbs, to monitor patients’ treatment response and to further guide dose adjustments. Serum has been the matrix of choice in the TDM of mAbs and its sampling requires the visit of the patients to laboratories that are not always easily accessible. Therefore, dried blood spots (DBS) and various microsampling techniques have been suggested as an alternative. DBS is a sampling technique in which capillary blood is deposited on a special filter paper. It is a relatively simple procedure, and the patients can perform the home-sampling. The convenience it offers has enabled its use in the quantification of small-molecule drugs, whilst in the recent years, studies aimed to develop microsampling methods that will facilitate the TDM of mAbs. Nevertheless, hematocrit still remains an obstacle that hinders a more widespread implementation of DBS in clinical practice. The introduction of novel analytical techniques and contemporary microsampling devices can be considered the steppingstone to the attempts made addressing this issue.     

Ku波段DBS平面天线发展综述

近十几年来,日本、欧洲和美洲等一些国家和地区相继发射了广播卫星,并开展了一系列Ku波段(12GHz)卫星直播(DBS)业务,促进了卫星电视接收技术的飞快发展,尤其是DBS平面天线的发展。本文介绍了DBS平面天线的基本原理、结构和特点。综述了DBS平面天线的技术现状和发展趋势,探讨了我国发展DBS平面天线的必要性和紧迫性。     

一种基于惯导信息的多普勒波束锐化图像拼接算法

通过多普勒波束锐化(Doppler Beam Sharpening, DBS)图像拼接可得到大范围的地面场景图像。然而实际中雷达平台的非理想运动(载机速度矢量和姿态的变化)会造成DBS图像拼接困难。为解决此问题,该文提出了一种有效的DBS图像拼接方法。首先利用惯导信息估计载机瞬时位置和雷达波束指向,然后将它们转化到初始时刻定义的参考坐标系下,得到图像校正参数。最后利用这些参数,完成图像拼接。实测数据的处理结果表明该文方法不仅较好地补偿了载机运动误差,而且与传统方法相比可以更好地改善DBS数据的拼接性能。     

Novel methodology to perform incurred sample reanalysis on dried blood spot cards: Experimental data using darolutamide and filgotinib

Different options on performing incurred sample reanalysis (ISR) on dried blood spot (DBS) cards were investigated using drugs belonging to various therapeutic areas: (a) darolutamide (to treat prostate cancer) and (b) filgotinib (to treat rheumatoid arthritis). The proposed novel methodology included the generation of half-DBS and quarter-DBS discs after initial blood collection using the full-DBS discs. Accordingly, blood collection via DBS was performed in male BALB/c mice following intravenous and oral dosing of darolutamide; in male Sprague Dawley rats following intravenous and oral dosing of filgotinib. The ISR data generated from the full-DBS disc, half-DBS disc and quarter-DBS disc were compared for the assessment of the proposed methodology. Quantification of darolutamide and filgotinib was accomplished using liquid chromatography-electrospray ionization/tandem mass spectrometry methods. Darolutamide and filgotinib ISR samples, which were collected and prepared using full-, half- and quarter-DBS discs, met the acceptance criteria for ISR analysis. In conclusion, this is the first report showing a viable tool for the performance of ISR on DBS cards. The use of quarter- or half-DBS discs would aid in not only ISR but also in long-term storage experiments of analytes because it would avoid the need for additional blood sampling in patients.     

Three-layer poly(methyl methacrylate) microsystem for analysis of lysosomal enzymes for diagnostic purposes

Lysosomal storage diseases are chronic, progressive and typically have a devastating impact on the patient and the family. The diagnosis of these diseases is still a challenge, however, even for trained specialists. Accurate diagnostic methods and high-throughput tools that could be readily incorporated into existing screening laboratories are urgently required.     

Measurements of RF heating during 3.0-T MRI of a pig implanted with deep brain stimulator

Purpose

To present preliminary, in vivo temperature measurements during MRI of a pig implanted with a deep brain stimulation (DBS) system.

Materials and Methods

DBS system (Medtronic Inc., Minneapolis, MN) was implanted in the brain of an anesthetized pig. 3.0-T MRI was performed with a T/R head coil using the low-SAR GRE EPI and IR-prepped GRE sequences (SAR: 0.42 and 0.39 W/kg, respectively), and the high-SAR 4-echo RF spin echo (SAR: 2.9 W/kg). Fluoroptic thermometry was used to directly measure RF-related heating at the DBS electrodes, and at the implantable pulse generator (IPG). For reference the measurements were repeated in the same pig at 1.5 T and, at both field strengths, in a phantom.

Results

At 3.0 T, the maximal temperature elevations at DBS electrodes were 0.46 °C and 2.3 °C, for the low- and high-SAR sequences, respectively. No heating was observed on the implanted IPG during any of the measurements. Measurements of in vivo heating differed from those obtained in the phantom.

Conclusion

The 3.0-T MRI using GRE EPI and IR-prepped GRE sequences resulted in local temperature elevations at DBS electrodes of no more than 0.46 °C. Although no extrapolation should be made to human exams and much further study will be needed, these preliminary data are encouraging for the future use 3.0-T MRI in patients with DBS.