Current methods for site-directed structure generation

Summary There has been a rapid growth of interest in techniques for site-directed drug design, fuelled by the increasing availability of structural models of proteins of therapeutic importance, and by studies reported in the literature showing that potent chemical leads can be obtained by these techniques. Structure generation programs offer the prospect of discovering highly original lead structures from novel chemical families. Due to the fact that this technique is more-or-less still in its infancy, there are no case studies available that demonstrate the use of structure generation programs for site-directed drug design. Such programs were first proposed in 1986, and became commercially available in early 1992. They have shown their ability to reproduce, or suggest reasonable alternatives for, ligands in well-defined binding sites. This brief review will discuss the recent advances that have been made in the field of site-directed structure generation.     

GaAs器件工艺中等离子刻蚀及计算机辅助监控技术研究

用Ｎ２气和ＮＦ３反应气体，在较低的刻蚀功率下实现了用薄正性光刻胶ＡＺ１５１８作掩模，均匀、快速刻蚀ＳｉＯ２，ＳｉＯＮ，Ｓｉ３Ｎ４，ＷＮ，Ｗ等材料的等离子刻蚀技术。利用到蚀过程中射频参数的变化和计算机技术，将射频参数的变化在计算机屏幕上实时显示，实现了计算机辅助监控和终点检测技术。     

四方向上的任意角度扇形数字滤波器的设计

具有任意角度（扇形所围成的角度）和任意方向（扇形所取方向）的扇形数字滤波器在图像数据压缩和地质、地震等方面的数据处理中有着广泛的应用。目前，大多数的工作多集中于水平及垂直方向的９０°扇形数字滤波器的设计，因而有必要研究任意方向上的任意角度的扇形数字滤波器的设计。本文介绍利用ＭｃＣｌｅｌｌａｎ交换法设计具有垂直，水平及±４５°方向上的任意角度的扇形数字滤波器的设计方法，垂直水平方向上的扇形滤波器的设     

面向表面组装工艺技术的PCB焊盘设计

尽管电子设计类软件已相当先进和方便，而且更新速度也很快，但是仍然无法满足各个层次的设计人员的需求，特别是适合各种元素封装形式的焊盘设计库并不能让设计和制造者满意，为了在此方面对PCB设计有所帮助，从印制电路板焊盘的设计方法入手，针对表面组装工艺技术特点，分析了PCB焊盘对PCA可靠性的影响因素，并根据相关的质量要求提出了较为简便的设计方案。     

洪水水文预报系统

水文预报系统是计算机算法应用于水文预报的一次实践 ,在从产汇流原理出发 ,详细阐述系统结构 ,工作原理及系统特征 ,还对软件的应用及今后开发前景进行了展望 ,随着社会发展和科技进步 ,实施计算机预报系统便于提高预报精度 ,增强水文预报的时效性 ,将使水文预报作用日益显著。     

一种高并行度的H.264帧内预测器的VLSI设计

分析了帧内预测的17种模式,对于每个4×4大小块的16个像素点的不同模式的预测公式之间的相同运算,采用数字强度缩减的方法去除计算的冗余,提出了一种高并行度的帧内预测器,可以每个时钟周期处理16个像素点的预测值。基于SMIC0.18μm工艺,用verilog对该设计进行了VLSI实现,综合后的电路的关键路径最大时延为10ns,电路规模不超过1.4万门,数据吞吐率可以达到1600Msamples/s。从实现结果来看,与采用可重构方法的设计相比,该设计在相同的并行度下减小了电路面积,简化了控制逻辑。     

Error Concealment Based on Semantic Prioritization with Hardware‐Based Face Tracking

With video compression standards such as MPEG‐4, a transmission error happens in a video‐packet basis, rather than in a macroblock basis. In this context, we propose a semantic error prioritization method that determines the size of a video packet based on the importance of its contents. A video packet length is made to be short for an important area such as a facial area in order to reduce the possibility of error accumulation. To facilitate the semantic error prioritization, an efficient hardware algorithm for face tracking is proposed. The increase of hardware complexity is minimal because a motion estimation engine is efficiently re‐used for face tracking. Experimental results demonstrate that the facial area is well protected with the proposed scheme.     

Optimal shape design for packaging containing heating elements by inverse heat transfer method

The present study is concerned with the determination of the optimal shape for a package containing multiple heating elements. The optimization tool has been developed based on the inverse heat transfer (IHT) approach, incorporating a direct problem solver, a numerical grid generator, a direct-differentiation sensitivity analyzer, and the conjugate gradient method. Shape design that leads to a specified outer surface temperature distribution is predicted by the approach. In this study, the effects of internal heat generation on optimal shapes of the packagings have also been evaluated. Several practical cases with various imbedded heating elements and thermal conditions are studied. Results show that the approach provides an efficient computer-aided design scheme for the shape profile determination.     

用电泳技术制备YBCO高温超导厚膜

介绍了电泳技术制备YBCO高温超导厚膜的实验方法和YBCO高温超导厚膜的电学性质测量 ,讨论了在学生小型科研实验或设计实验中开展此实验的学时安排、注意事项和实验内容的扩展 .