Synthesis,characterization, and application of griseofulvin surface molecularly imprinted polymers as the selective solid phase extraction sorbent in rat plasma samples

In present study, an investigation was carried out to develop and validate an analytical method for the selective extraction and determination of griseofulvin (GSF) from plasma samples. For this purpose, a rational approach was made to synthesize and characterize the surface molecularly imprinted polymers (SMIPs). The SMIPs were utilized as solid phase extraction (SPE) sorbents. The SMIPs were prepared by using GSF as template molecule on the surface of modified silica particles through a non-covalent technique. The particles demonstrated high adsorption capacity (119.1 µg/mL), fast adsorption equilibrium time (30 min) and good recognition selectivity for the template drug. The scanning electron microscopy and infrared spectroscopy were used to explain the structural and morphological characteristics of the SMIPs and surface non-imprinted polymers. The SPE method was combined with HPLC for plasma analysis. The method validation results demonstrated that the established method possessed good linearity for GSF ranging from 0.1 to 50 µg/mL (R² = 0.997). The limit of detection for this method was 0.02 µg/mL for rat plasma samples. The recoveries of GSF from spiked plasma samples were (90.7–97.7%) and relative standard deviations were (0.9–4.5%). Moreover, the SMIPs as selective SPE sorbent can be reused more than 8 times which is a clear advantage over commercial SPE sorbents. Finally, the usefulness of the proposed strategy was assessed by extraction and detection of GSF in real rat plasma samples.     

O3有效钝化多孔硅的研究

开发了用O3氧化钝化多孔Si（PS）的实用工艺方法。O3的基本作用是对Si-Hx和Si悬挂键（DB）的充分氧化，经过随后158d贮存的老化实验，得到了表面Si—H，键完全被Si-O3膜和Si-烷基膜所替代并覆盖的PS，其光致发光（PL）强度达到稳定的增强，这归因于PS纳米晶粒的表面势垒高度的提高以及量子效率的提高。     

双极场逆Radon变换的数值模拟

对双极场（DPF）的逆Radon变换进行了数值模拟。采用加法代数重建迭代算法（ART）对含有正负值的DPF进行重建，迭代了500次。结果发现，迭代一直收敛，重建场与原场相似，包括峰的位置、方向和形状，但各个峰的高度都较原场相应的峰矮，重建区域的边界出现了明显的波动现象。与相应单极场（SPF）的重建误差作比较，结果发现，DPF的3种模拟误差都大于SPF相应的误差，其中均方误差（MSE）大10^-4数量级，绝对平均误差（AVE）、峰值相对误差（PE）分别大10^-3、10^-2数量级，说明同样条件下DPF的重建精度比SPF的小。     

GPS电子地图坐标转换算法研究

GPS车载导航系统现在已经运用得十分广泛,然而GPS采用的是WGS-84坐标系,目前我国的各类地图均采用54北京坐标或是80西安坐标,两者的差距可达0～120m.要使用各类电子导航装置就需要把WGS-84坐标转换到54北京坐标系下,并和电子地图中的像素点对应起来.本文主要介绍一种坐标转换算法,并且通过实测检验,证实算法效果良好.     

基于小波变换的在役管线漏磁信号的去噪

采用漏磁法对在役管线进行无损检测时,所采集的信号中含有大量的噪声需要去除。文中介绍了小波变换的基本理论及检测信号和噪声信号在小波变换下的特性,说明了去除漏磁信号噪声的原理。在仿真试验中采用二阶双正交样条小波为小波函数,选用软硬阈值折中法和自适应阈值处理小波系数,结果表明将小波变换应用于在役管线漏磁检测中,能很好地去除噪声,提取出有用信号。     

数学形态学与hough变换在医学图像中的应用

利用数学形态学对含有胎儿头部轮廓的医学图像进行预处理,提取近似圆形的胎儿大脑轮廓的骨架.利用hough变换自动逼近,获得最逼近胎儿大脑轮廓的圆周,此圆周的直径可以近似双顶径.     

黑米花色苷酰化修饰红外光谱分析

黑米花色苷易受外部环境影响发生降解致使局部分子结构破坏而使营养价值和保健功能有所下降。利用有机酸提供酰基对黑米花色苷进行修饰来提高花色苷结构的稳定性。利用红外光谱分析经咖啡酸酰化修饰黑米花色苷的结构变化。结果表明：黑米花色苷酰化修饰前后于官能团区3 650~3 200和1 680~1 620 cm-1处均有吸收峰，且其于指纹区1 282.68和1 277.51 cm-1处出现酚羟基吸收峰，于1 056.07和1 054.03 cm-1处出现醇羟基吸收峰，719.90和719.71 cm-1处出现苯环上C-H面外弯曲振动吸收峰。由此可见，黑米花色苷酰化修饰后主要结构框架仍为花色苷的芳环结构。此外，黑米花色苷酰化修饰前后于1 900~1 650 cm-1间1 714.28和1 728.13 cm-1处均出现共轭羰基的特征吸收峰，对应于可直接连接在苯环上的α-羰基结构，由此说明黑米花色苷结构中存在着酰基基团。黑米花色苷经酰化修饰后红外图谱于1 517.20 cm-1处出现新吸收峰，其正好处于1 800~900 cm-1双键(不含氢)伸缩振动区，指纹区876.65 cm-1处亦出现了苯环上的C-H面外弯曲振动吸收峰。与之相呼应在经二阶导数处理后红外光谱图中在2 500～2 000 cm-1间出现了新的波动，此波段为累积双键伸缩振动区，而官能团区3 650~3 200 cm-1间3 370.20 cm-1处的吸收峰正好处于多分子缔合区。由此可见，在咖啡酸作为酰基供体，酰化修饰黑米花色苷时由于分子间的重新缔合于结构中引入了新的酰基基团而呈现出一种双酰化的空间结构。黑米花色苷酰化结构中有机酸与糖链相连，将有机酸置于2-苯基苯并吡喃骨架的表面，这种堆积作用模式可以较好地抵抗水的亲核攻击和其他降解反应进而提高黑米花色苷结构的稳定性。     

The raised-cosine wavelets in computerized tomography

In Computerized Tomography (CT), an image must be recovered from its sampled projections in the form of values of the Radon transform. In this work a method of recovering the image is based on the properties of the raised-cosine wavelet. This wavelet has a closed form which allows for certain precomputations and avoids convolution. The rate of convergence of the resulting algorithm to the image density function is found under suitable hypotheses. This algorithm is then tested on the standard Shepp–Logan     

Lattice Vector Quantization Applied to Speech and Audio Coding

Lattice vector quantization(LVQ) has been used for real-time speech and audio coding systems.Compared with conventional vector quantization,LVQ has two main advantages:It has a simple and fast encoding process,and it significantly reduces the amount of memory required.Therefore,LVQ is suitable for use in low-complexity speech and audio coding.In this paper,we describe the basic concepts of LVQ and its advantages over conventional vector quantization.We also describe some LVQ techniques that have been used in speech and audio coding standards of international standards developing organizations(SDOs).