全文获取类型
收费全文 | 4362篇 |
免费 | 600篇 |
国内免费 | 328篇 |
专业分类
化学 | 1908篇 |
晶体学 | 27篇 |
力学 | 208篇 |
综合类 | 34篇 |
数学 | 322篇 |
物理学 | 753篇 |
无线电 | 2038篇 |
出版年
2024年 | 12篇 |
2023年 | 54篇 |
2022年 | 56篇 |
2021年 | 78篇 |
2020年 | 161篇 |
2019年 | 181篇 |
2018年 | 145篇 |
2017年 | 195篇 |
2016年 | 230篇 |
2015年 | 237篇 |
2014年 | 303篇 |
2013年 | 288篇 |
2012年 | 284篇 |
2011年 | 354篇 |
2010年 | 260篇 |
2009年 | 223篇 |
2008年 | 292篇 |
2007年 | 301篇 |
2006年 | 227篇 |
2005年 | 212篇 |
2004年 | 193篇 |
2003年 | 199篇 |
2002年 | 162篇 |
2001年 | 137篇 |
2000年 | 120篇 |
1999年 | 103篇 |
1998年 | 80篇 |
1997年 | 46篇 |
1996年 | 30篇 |
1995年 | 22篇 |
1994年 | 17篇 |
1993年 | 19篇 |
1992年 | 21篇 |
1991年 | 11篇 |
1990年 | 7篇 |
1989年 | 8篇 |
1988年 | 3篇 |
1987年 | 2篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1981年 | 2篇 |
1977年 | 1篇 |
1973年 | 1篇 |
1968年 | 2篇 |
1966年 | 1篇 |
1959年 | 1篇 |
排序方式: 共有5290条查询结果,搜索用时 0 毫秒
161.
基于PBAC模型和IBE的医疗数据访问控制方案 总被引:1,自引:0,他引:1
医疗卫生领域形成的医疗大数据中包含了大量的个人隐私信息,面临着外部攻击和内部泄密的潜在安全隐患。传统的访问控制模型没有考虑用户访问目的在侧重数据隐私的访问控制中的重要作用,现有的对称、非对称加密技术又都存在密钥管理、证书管理复杂的问题。针对这些问题,提出了综合应用PBAC模型和IBE加密技术的访问控制方案,支持针对医疗数据密文的灵活访问控制。通过加入条件目的概念对PBAC模型进行扩展,实现了对目的树的全覆盖;以病患ID、条件访问位和预期目的作为IBE身份公钥进行病患数据加密,只有通过认证并且访问目的符合预期的用户才能获得相应的私钥和加密数据,从而实现对病患信息的访问。实验结果证明,该方案达到了细粒度访问控制和隐私保护的目的,并具有较好的性能。 相似文献
162.
随着社会和科技的不断发展,计算机的应用已经很普及,本文针对任务驱动法进行概述,分析了任务驱动法在高校计算机基础课程中的实践,提出了要明确教学目标、及时对学生进行指导、及时进行纠错,发现教学难点、及时进行归纳总结的实践方法。 相似文献
163.
TD-LTE网络基于AoA+TA功能的接入控制应用 总被引:1,自引:1,他引:0
秦嗣仲 《电信工程技术与标准化》2015,(2):20-24
本文论述了在TD-LTE网络中遇见的新问题,即边境优化问题。中国移动TD-LTE网络建设与朝鲜隔江而建,参考丹东边境GSM网络的方法,结合TD-LTE网络自身特点,TD-LTE网络采用宏站小区覆盖朝鲜新义州沿江区域,令宏站小区采用基于位置的接纳控制算法(如Ao A+TA方法等),通过UE距离站点的远近限制朝鲜用户接入TD-LTE网络进行业务。 相似文献
164.
Paola Peluso Victor Mamane Emmanuel Aubert Sergio Cossu 《Journal of separation science》2013,36(18):2993-3003
The HPLC enantioseparation of nine atropisomeric 3,3′,5,5′‐tetrasubstituted‐4,4′‐bipyridines was performed in normal and polar organic (PO) phase modes using two immobilized polysaccharide‐based chiral columns, namely, Chiralpak IA and Chiralpak IC. The separation of all racemic analytes, the effect of the chiral selector, and mobile phase (MP) composition on enantioseparation and the enantiomer elution order (EEO) were studied. The beneficial effect of nonstandard solvents, such as tetrahydrofuran (THF), dichloromethane (DCM), and methyl t‐butyl ether on enantioseparation was investigated. All selected 4,4′‐bipyridines were successfully enantioseparated on Chiralpak IA under normal or PO MPs with separation factors from 1.14 to 1.70 and resolutions from 1.3 to 6.5. Two bipyridines were enantioseparated at the multimilligram level on Chiralpak IA. Differently, Chiralpak IC was less versatile toward the considered class of compounds and only five bipyridines out of nine could be efficiently separated. In particular, on these columns, the ternary mixture n‐heptane/THF/DCM (90:5:5) as MP had a positive effect on enantioseparation. An interesting phenomenon of reversal of the EEO depending on the composition of the MP for the 3,3′‐dibromo‐5,5′‐bis‐(E)‐phenylethenyl‐4,4′‐bipyridine along with an exceptional enantioseparation for the 3,3′‐dibromo‐5,5′‐bis‐ferrocenylethynyl‐4,4′‐bipyridine (α = 8.33, Rs = 30.6) were observed on Chiralpak IC. 相似文献
165.
Květa Kalíková Petr Kozlík Martin Gilar Eva Tesařová 《Journal of separation science》2013,36(15):2421-2429
Hydrophilic interaction liquid chromatography is a separation technique suitable for the separation of moderately and highly polar compounds. Various stationary phases (SPs) for hydrophilic interaction liquid chromatography are commercially available. While the SPs based on the same type of ligand are available from different providers, they can display a distinct retention characteristics and separation selectivity. The current work is focused on characterization and comparison of the separation systems of two amide‐based HPLC columns from two producers, i.e. XBridge Amide column and TSK gel Amide‐80 column. Several characterization procedures (tests) were used to investigate the differences between these columns. The chromatographic behavior of selected analytes indicates that multimodal interactions are responsible for retention and separation on these columns. Multiple testing approaches were used in order to reveal subtle differences between the SPs. Both amide‐based columns showed certain differences in retention, selectivity, and plate counts. Based on the tests used in this study, we conclude that the investigated columns provide a different degree of H‐bonding interactions. 相似文献
166.
Karine Vuignier Szabolcs Fekete Pierre‐Alain Carrupt Jean‐Luc Veuthey Davy Guillarme 《Journal of separation science》2013,36(14):2231-2243
In the present study, three types of silica‐based monoliths, i.e. the first and second generations of commercial silica monolithic columns and a wide‐pore prototype monolith were compared for the analysis of large biomolecules. These molecules possess molecular weights between 1 and 66 kDa. The gradient kinetic performance of the first‐generation monolith was lower than that of the second generation, for large biomolecules (>14 kDa) but very close with smaller ones (1.3–5.8 kDa). In contrast, the wide‐pore prototype column was particularly attractive with proteins larger than 19 kDa (higher peak capacity). Among these three columns, the selectivity and retention remained quite similar but a possible larger number of accessible and charged residual silanols was noticed on the wide‐pore prototype material, which led to unpredicted small changes in selectivity and slightly broader peaks than expected. The peak shapes attained with the addition of 0.1% formic acid in the mobile phase remained acceptable for MS coupling, particularly for biomolecules of less than 6 kDa. It was found that one of the major issues with all of these silica‐based monoliths is the possible poor recovery of large biomolecules (principally with monoclonal antibody fragments of more than 25 kDa). 相似文献
167.
A simple and convenient method for the aromatization of Hantzsch 1,4-dihydropyridines to the corresponding pyridines is achieved via combination of aluminum or ferric nitrates and silica sulfuric acid as environmentally friendly and novel oxidizing media. This oxidation was carried out in dichloromethane under heterogeneous conditions with good to excellent yields. 相似文献
168.
Carbon‐based solid acid was used as a new catalyst for conversion of trimethylsilyl ethers to their corresponding ethers in heterogeneous mixtures. The experiments were done moderately at room temperature, and high yields in suitable times were obtained under these conditions. 相似文献
169.
Dr. Alessandro Barge Marina Caporaso Prof. Giancarlo Cravotto Dr. Katia Martina Dr. Paolo Tosco Prof. Silvio Aime Dr. Carla Carrera Dr. Eliana Gianolio Dr. Giorgio Pariani Dr. Davide Corpillo 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(36):12086-12092
We report the synthesis and characterization of a water‐soluble, star‐shaped macromolecular platform consisting of eight β‐cyclodextrin (β‐CD) units anchored to the narrower rim of a γ‐CD core through bis(triazolyl)alkyl spacers. The efficient synthetic protocol is based on the microwave (MW)‐promoted Cu‐catalyzed 1,3‐dipolar cycloaddition of CD monoazides to CD monoacetylenes. The ligand‐hosting capability of the construct has been assessed by relaxometric titration and nuclear magnetic relaxation dispersion (NMRD) profiling, which showed it to be good, and this was supported by molecular dynamics simulations. To demonstrate the feasibility of obtaining supramolecular structures with high hosting ability, we designed a dimeric platform, formed by joining two nonamers through the γ‐CD cores through a bis(lithocholic acid) linker. With a view to the potential biological applications, cytotoxicity and extent of binding to human serum albumin were assessed. The properties of this dendrimeric multicarrier make it suitable for pharmaceutical and diagnostic purposes, ranging from targeted drug delivery to molecular imaging. 相似文献
170.
We have developed a FRET-based ratiometric fluorescent probe for the detection of CN− using a fluorescein–Zn–naphthalene ensemble (NFH·Zn2+). The sensing mechanism was ascribed by displacement approach. The chemosensor exhibits high selectivity and sensibility for CN−. The speculation was supported by fluorescence emission spectra, UV–vis spectrum, 1H NMR titration experiments, and mass spectra. The interconversion of probe NFH and NFH·Zn2+ via the complexation/decomplexation by the modulation of Zn2+/CN− mimics INHIBIT gate. In addition, it also shows an excellent performance in ‘dip stick’ method. 相似文献