Amyloid Against Amyloid: Dimeric Amyloid Fragment Ameliorates Cognitive Impairments by Direct Clearance of Oligomers and Plaques

Amyloid-β (Aβ) in the form of neurotoxic aggregates is regarded as the main pathological initiator and key therapeutic target of Alzheimer's disease. However, anti-Aβ drug development has been impeded by the lack of a target needed for structure-based drug design and low permeability of the blood–brain barrier (BBB). An attractive therapeutic strategy is the development of amyloid-based anti-Aβ peptidomimetics that exploit the self-assembling nature of Aβ and penetrate the BBB. Herein, we designed a dimeric peptide drug candidate based on the N-terminal fragment of Aβ, DAB, found to cross the BBB and solubilize Aβ oligomers and fibrils. Administration of DAB reduced amyloid burden in 5XFAD mice, and downregulated neuroinflammation and prevented memory impairment in the Y-maze test. Peptide mapping assays and molecular docking studies were utilized to elucidate DAB-Aβ interaction. To further understand the active regions of DAB, we assessed the dissociative activity of DAB with sequence modifications.     

基于FPGA的高精度图像采集系统设计

为了获取更高精度的图像，文章设计了一套基于FPGA结合高精度AD的CMOS图像探测器图像采集系统。首先通过串口配置图像探测器和AD的寄存器，使其按照成像要求进行工作，然后将高速串行差分图像输入Xilinx FPGA，综合运用差分转换、高速数据解串、数据时钟域转换等设计方法，使图像满足系统应用和存储与显示要求。实验表明，当AD的输出时钟高达240MHz时，系统能够准确、平稳的输出30MHz的14位高精度图像。