100 Gbit/s Nyquist-WDM PDM 16-QAM Transmission over 1200 km SMF-28 with Ultrahigh Spectrum Efficiency

Nyquist wavelength-division multiplexing (N-WDM) allows high spectral efficiency (SE) in long-haul transmission systems.Compared to polarization-division multiplexing quadrature phase-shift keying (PDM-QPSK),multilevel modulation,such as PDM 16 quadrature-amplitude modulation (16-QAM),is much more sensitive to intrachannel noise and interchannel linear crosstalk caused by N-WDM.We experimentally generate and transmit a 6 × 128 Gbit/s N-WDM PDM 16-QAM signal over 1200 km single-mode fiber (SMF)-28 with amplification provided by an erbium-doped fiber amplifier (EDFA) only.The net SE is 7.47 bit/s/Hz,which to the best of our knowledge is the highest SE for a signal with a bit rate beyond 100 Gbit/s using the PDM 16-QAM.Such SE was achieved by DSP pre-equalization of transmitter-side impairments and DSP post-equalization of channel and receiver-side impairments.Nyquist-band can be used in pre-equalization to enhance the tolerance of PDM 16-QAM to aggressive spectral shaping.The bit-error ratio (BER) for each of the 6 channels is smaller than the forward error correction (FEC) limit of 3.8 × 10-3 after 1200 km SMF-28 transmission.     

Growth order and stability of semigroups and cosine operator functions

Equivalent conditions for a trajectory of a C₀-semigroup T(⋅) (resp. cosine function C(⋅)) of operators to have the growth order O(tα) or o(tα) are expressed in terms of Cesàro and Abel means of the norm of the trajectory. We then deduce characterizations of growth order and stability for T(⋅) and C(⋅). It is also shown that under some Tauberian condition the uniform boundedness (resp. strong convergence) of T(⋅) is equivalent to the uniform boundedness (resp. strong convergence) of its Abel means.     

Hypergeometric solutions for Coulomb self-energy model of uniformly charged hollow cylinder

The article aims at studying hypergeometric-type mathematical techniques based on the extension of a model previously used to describe the Coulomb self-energy of a uniformly charged a three-dimensional cylinder. The associated crossed term integral is investigated and solved by introducing a computational series built from hypergeometric-type terms for different values of parameters involved. The approach considered may be appealing for a broad audience of researchers working in mathematical physics or related disciplines.     

Novel Hybrid Benzoazacrown Ligand as a Chelator for Copper and Lead Cations: What Difference Does Pyridine Make

A synthetic procedure for the synthesis of azacrown ethers with a combination of pendant arms has been developed and the synthesized ligand, characterized by various techniques, was studied. The prepared benzoazacrown ether with hybrid pendant arms and its complexes with copper and lead cations were studied in terms of biomedical applications. Similarly to a fully acetate analog, the new one binds both cations with close stability constants, despite the decrease in both constants. The calculated geometry of the complexes correlate with the data from X-ray absorption and NMR spectroscopy. Coordination of both cations differs due to the difference between the ionic radii. However, these chelation modes provide effective shielding of cations in both cases, that was shown by the stability of their complexes in the biologically relevant media towards transchelation and transmetallation.     

64CuCl2 PET Imaging of 4T1-Related Allograft of Triple-Negative Breast Cancer in Mice

⁶⁴CuCl₂ is an economic radiotracer for oncologic PET investigations. In the present study, we characterized the uptake of ⁶⁴CuCl₂ in vivo by µPET/CT in an allograft 4T1-related mouse model (BALB/c) of advanced breast cancer. ¹⁸F-FDG was used as a comparator. Twenty-two animals were imaged 7–9 days following 4T1-cell implantation inside mammary glands. Dynamic ⁶⁴CuCl₂ µPET/CT acquisition or iterative static images up to 8 h p.i. were performed. Animal biodistribution and tumor uptake were first evaluated in vivo by µPET analysis and then assessed on tissue specimens. Concerning ¹⁸F-FDG µPET, a static acquisition was performed at 15 min and 60 min p.i. Tumor ⁶⁴CuCl₂ accumulation increased from 5 min to 4 h p.i., reaching a maximum value of 5.0 ± 0.20 %ID/g. Liver, brain, and muscle ⁶⁴CuCl₂ accumulation was stable over time. The tumor-to-muscle ratio remained stable from 1 to 8 h p.i., ranging from 3.0 to 3.7. Ex vivo data were consistent with in vivo estimations. The ¹⁸F-FDG tumor accumulation was 8.82 ± 1.03 %ID/g, and the tumor-to-muscle ratio was 4.54 ± 1.11. ⁶⁴CuCl₂ PET/CT provides good characterization of the 4T1-related breast cancer model and allows for exploration of non-glycolytic cellular pathways potentially of interest for theragnostic strategies.     

Chelation of Theranostic Copper Radioisotopes with S-Rich Macrocycles: From Radiolabelling of Copper-64 to In Vivo Investigation

Copper radioisotopes are generally employed for cancer imaging and therapy when firmly coordinated via a chelating agent coupled to a tumor-seeking vector. However, the biologically triggered Cu²⁺-Cu⁺ redox switching may constrain the in vivo integrity of the resulting complex, leading to demetallation processes. This unsought pathway is expected to be hindered by chelators bearing N, O, and S donors which appropriately complements the borderline-hard and soft nature of Cu²⁺ and Cu⁺. In this work, the labelling performances of a series of S-rich polyazamacrocyclic chelators with [⁶⁴Cu]Cu²⁺ and the stability of the [⁶⁴Cu]Cu-complexes thereof were evaluated. Among the chelators considered, the best results were obtained with 1,7-bis [2-(methylsulfanyl)ethyl]-4,10,diacetic acid-1,4,7,10-tetraazacyclododecane (DO2A2S). DO2A2S was labelled at high molar activities in mild reaction conditions, and its [⁶⁴Cu]Cu²⁺ complex showed excellent integrity in human serum over 24 h. Biodistribution studies in BALB/c nude mice performed with [⁶⁴Cu][Cu(DO2A2S)] revealed a behavior similar to other [⁶⁴Cu]Cu-labelled cyclen derivatives characterized by high liver and kidney uptake, which could either be ascribed to transchelation phenomena or metabolic processing of the intact complex.