胸导管远端的正常CT表现及其临床意义

胸导管的病变罕见，可发生在纵隔（胸导管穿行于其中）或颈部（胸导管在此汇入静脉系统）。其中胸导管囊样扩张（胸导管囊肿）最为常见，多发生于后纵隔。胸导管远端扩大在影像学上可被误认为反应性淋巴结肿大、先天性囊肿或淋巴结转移。提高对颈部胸导管正常解剖结构CT影像的认识，可以避免或减少将横断面上扩张的胸导管误认为病灶，从而避免或减少不必要的干预。本文通过分析颈部胸导管远端CT显示率及其表现特点，以期提高临床医师对胸导管病变的认识。     

A High-affinity Activator of G551D-CFTR Chloride Channel Identified By High Throughput Screening

A stably transfected CHO cell line coexpressing G551D-CFTR and iodide-sensitive yellow fluorescent protein mutant EYFP-H148Q-I152L was successfully established and used as assay model to identify smallmolecule activators of G551D-CFTR chloride channel from 100000 diverse combinatorial compounds by high throughput screening on a customized Beckman robotic system. A bicyclooctane compound was identified to activate G551D-CFTR chloride channel with high-affinity(Kd=1.8 μmol/L). The activity of the bicyclooctane compound is G551D-CFTR-specific, reversible and non-toxic. The G551D-CFTR activator may be useful as a tool to study the mutant G551D-CFTR chloride channel structure and transport properties and as a candidate drug to cure cystic fibrosis caused by G551D-CFTR mutation,     

CO2激光治疗前庭大腺囊肿112例报告

前庭大腺囊肿是妇产科常见病之一，多因感染，创伤而致腺体导管阻塞，腺体膨大形成囊肿。目前该病治疗方法为手术切除囊肿或囊肿造口术，两者均操作繁琐，易出血，且需病人住院治疗，前者破坏了腺体的正常分泌功能，对性生活质量有很大影响，而后者较易复发。     

鼻内窥镜下切除侵犯颅底的鼻窦囊肿

目的：探讨在鼻内窥镜下切除侵犯颅底的巨大鼻窦囊肿的可行性。方法：对３例侵犯颅底的巨大鼻窦整肿采用鼻内窥镜下手术的回顾性分析及文献复习。结果：３例手术获得成功，临床症状消失，无并发症，随访１～４均无复发，结论：鼻内窥镜下切除侵犯颅底巨大鼻窦囊肿是一个安全有效的术式，并且创伤小、恢复快、并发症少。     

CO2激光治疗前庭大腺囊肿8例

外阴前庭大腺囊肿是妇女常见病,易合并感染。我科门诊自1990年6月开始用CO_2激光治疗前庭大腺囊肿8例,均获得满意疗效。现就疗效,随访结果报导如下。     

CO2激光治疗皮脂腺痣54例报告

ＣＯ２激光治疗皮脂腺痣５４例报告杨延安揣瑞梅庞月光（济南市皮肤病防治院，２５００２１）我院自１９８８年～１９９６年，采用ＣＯ２激光切割及扩焦照射治疗皮脂腺痣５４例，效果满意，现报告如下：１临床资料５４例患者中男２８例，女２８例；年龄最小８岁，最大３...     

Dictamine Stimulates Cystic Fibrosis Transmembrane Conductance Regulator CL Transport

Dictamine is a furoquinoline alkaloid isolated from Dictamus dasycarpus Turcz.In the present study,we found that dictamine is able to stimulate the chloride transport activity of wild-type and ΔF508 mutant CFTR.The activity is cAMP-dependent and can be completely reversed by specific CFTR inhibitor CFTRinh-172.In addition,dictamine can further increase the chloride transport activity when CFTR is maximally activated by the combination of cAMP stimulators forskolin(FSK)and IBMX,suggesting direct interaction of dictamine with CFTR.Dictamine may be useful for probing CFTR channel gating mechanisms and used as a lead compound to develop the pharmacological therapy of CFTR-related diseases such as idiopathic chronic pancreatitis and keratoconjunctivitis sicca and cystic fibrosis.     

蝶窦粘液囊肿6例报告

１一般资料 本组６例中,男 ４例,女２例,年龄１３～６７岁,平均 ５０岁,病程２０ｄ～１４年不等,平均为４年．临床表现：头痛５例,视力下降３例,失明２例,复视１例,上睑下垂１例,眼球外展受限１例,鼻阻２例,流涕３例．本组病例行ＣＴ扫描４例,ＭＲＩ检查３例,蝶窦诊断性穿刺２例,每例均行鼻内窥镜检查．本组病例均经手术治疗,术后病理检查结果,粘液囊肿５例,脓囊肿１例．２手术方法 手术进路包括筛窦进路５例（鼻外筛窦进路１例,鼻内筛窦经路４例）,经腭部进路１例,现主要讲述内窥镜下鼻内蝶窦开放术．手术时,患者取…