脱羧氯雷他定的合成

脱羧氯雷他定 (ＤＣＬ)是一种有效的非镇定性抗组织胺 ,对过敏性鼻炎 ,糖尿病、咳嗽、普通感冒、流行性感冒、关节痛及其它不适症状都有很好的疗效[1～2 ] 。它克服了氯雷他定、酮康唑、红霉素、伊曲康唑等易引发黑色素瘤、纤维肉瘤、胃刺激、肥胖症、心律失调、传导紊乱等症状的缺点。且它的使用剂量只有氯雷他定的十分之一 ,有很好的市场前景和实际应用价值。ＭａｒｋＷ .Ｈｏｌｌａｄａｙｅｔａｌ[3] 在水溶液中由酸、碱催化得到了脱羧氯雷他定 ,但无具体操作和反应结果报道。Ａ .Ｋ .ＧｕｎｎａｒＡｂｅｒｇ[1] 直接用ＫＯＨ在绝对无水…     

A Novel Method for Quantification of Circulating DNA in Serum by Capillary Zone Electrophoresis

In this paper, we first presented a novel method for quantification of circulating DNA in human serum based on capillary zone electrophoresis with laser-induced fluorescence detection (CZE-LIF). The serum was digested by proteinase to release free DNA, and then CZE-LIF system was used for the quantification of total circulating DNA. This method was successfully used to quantify the circulating DNA levels in sera from healthy individuals and certain cancer patients.We found the significantly elevated circulating DNA levels in certain prostate cancer patients. Our results demonstrated that CZE-LIF system has good linearity, excellent sensitivity (0.5 ng/mL DNA),satisfactory reproducibility (RSDs in one day and between days were both less than 5%) and reliability, and is well suitable to the quantification of the circulating DNA in human serum or plasma.     

Solution Structure and Behavior of Benzophenone-based Achiral Bisphosphine Ligands in Noyori-Type Ru（Ⅱ）-Catalysts

We herein report on solution structural studies of Ru^Ⅱ catalysts （3a, 9） composed of achiral bisphosphine ligands （4, 8） and the enantiopure 1,2-diphenylethylenediamine （DPEN）. Complete chiral induction from enantiopure （R,R）-DPEN to achiral bisphosphine ligand 3a was observed in solution, with the complex adopting a single, stable and non-fluxional （even at 70 ℃） configuration. The coordination of the C=O moiety in 4 to the cationic Run center is considered to be of key importance in providing the higher thermodynamic and kinetic rotation barrier for the flexible bisphosphine ligand in the complex. The obtained enantioselectivity （91% enantiomeric excess） and sense of chiral induction in the hydrogenation of acetophenone were found to be solely dependent on the chirality of the 1,2-diamine. Consistent with the hydrogenation product, the （R,R）-DPEN induces a M-conformation （fight-handed） chirality for flexible phosphine ligand 4 in the complex, resulting in a 2,2-configuration about the Ru^Ⅱ center.     

QuickLogic为功耗敏感应用量身打造PolarPro FPGA器件

目前，通讯仍然是PLD最大的应用市场，但据QuickLogic公司亚太区总经理冯远辉介绍，自2005年之后，PLD在消费电子市场的增长将会呈现迅猛势头，在工控市场上比较活跃的QuickLogic将会凭他们的低功耗FPGA产品PolarPro系列进军消费电子市场。     

加速度传感器在便携式设备中的应用

加速度传感器在便携式设备中的应用原理加速度传感器可以测量两种加速度值,第一种是静态加速度,第二种是动态加速度。所谓静态加速度是指地球的重力场,加速度传感器可以通过检测地球的重力场与加速度传感器感应轴的分量的大小来检测出倾斜角的变化。由图1可以看出,感应轴与地球重力场的夹角,与其所承受的重力加速度是存在一种正弦函数关系,因此,可以通过倾斜便携设备实现前后左右方面的控制。     

英飞凌为感应加热应用推出新一代逆导IGBT

正2014年2月24日,英飞凌科技股份公司推出单片集成逆导二极管的20A 1350 V器件,再次扩充逆导(RC)软开关IGBT(绝缘栅双极型晶体管)产品组合。新的20A RC-H5是对英飞凌性能领先的RC-H系列的扩展,重点关注感应加热应用的系统效率和高可靠性要求。与前几代产品相比,RC-H5的开关损耗降低高达30%,使设计人员能够使用IGBT的工作频率高达30 kHz。因此,配备RC-H5的系统效率提高     

基于Zigbee无线传感器网络的智能灯光跟随系统

设计一个基于Zigbee的智能灯光跟随系统。系统中连接有人体红外热释电传感器的Zigbee结点等距离分布在走廊或道路的旁边,检测特定区域人员是否存在的信息,并将信息传于协调器节点,协调器节点连接主控制器PX-A270,PXA270根据采集的信息控制舵机的转向和照明装置的亮与灭,实现有人走动存在时,灯光随着人的转移而转移,无人时照明系统自动熄灭,从而实现节约能源的效果。     

机动型气象雷达的防雷设计

针对机动型气象雷达的工作特点和雷电伤害的不同种类,提出了一种防雷设计思路,并对具体的防雷装置的选用和安装作了较为详细的阐述。     

Investigations of ionization-induced injection of laser wake field acceleration using phenomenological model

We develop a phenomenological model to investigate dynamics of ionization-induced injection. In the ＂bubble＂ regime of laser wakefield acceleration （LWFA）, it is found that there is an upper limit for laser intensity of ionization-induced injection. In the plane perpendicular to the laser polarization, when the laser pulse is linearly polarized, ionization-induced injected electrons exhibit a filamented structure and semi-coherent betatron oscillation.     

对一道竞赛题的探讨

为了有助于了解磁悬浮列车的牵引力的来由，给出了两种方法计算安培力的大小．