Efficient, mild, parallel and purification-free synthesis of aryl ethers via the Mitsunobu reaction

A wide range of commercial diazodicarboxylates and phosphines were screened in an attempt to find purification-free conditions for application in parallel synthesis. The combination of immobilized triphenylphosphine and TMAD proved to be suitable for the synthesis of aryl ethers via the Mitsunobu reaction. Nine ethers were synthesized in good yield and excellent purity, the purification being limited to a filtration step.     

Impact of <Emphasis Type="Italic">θ</Emphasis>-burst stimulation on memory mechanism: modeling study

The information stored in working memory can be transformed into the system of long-term memory due to the long-term potential (LTP) mechanism. The θ-burst stimulation (TBS) can be used as an LTP induction protocol in some experiments, but it has not been used in the models related to memory. In this work, an improved Camperi-Wang (C-W) model with the Ca²⁺ subsystem-induced bistability is adopted, and the TBS is simulated to be the initial stimuli of this model. With the evolution of the effects of the stimuli properties such as the cycle, the amplitude, and the duty ration on the memory mechanism of this model, the TBS can be adopted to activate working memory models and produce long-term memory. The study helps to propose the relationship between working memory and long-term memory, which lays a theoretical basis for the study of the neural mechanism of long-term memory.     

CN HCCB TBS 的LOFA 与真空室内LOCA 初步分析

基于CN HCCB TBS 的最新设计,用RELAP 5 软件对失流事故(LOFA)和真空室内失冷事故(In-vessel LOCA)这两种假设基本事故进行了分析。结果表明,CN HCCB TBS 在这两种事故工况下的安全性是有保证的,并且热工水力学瞬态分析能给出有关发生事故时TBM 安全性相关性能的信息,从而提出了所需要的各种安全保护系统及其动作的时间。     

Silyl group deprotection by Pd/C/H2. A facile and selective method

An easy, high yield, RT, short-reaction-time Pd/C hydrogenation of silyl groups is described. This includes TES, TPS, TBS, TBDMS, TIPS, and TBDPS. The relative selectivity of the process has been investigated and we can show, for example, that TES, TPS, TBS, and TBDMS removal can be performed in the presence of TIPS and TBDPS.