Orbital Symmetry in QSAR: Some Schiff's Base Inhibitors of Carbonic Anhydrase

Abstract

In a reexamination of some data on the inhibition of carbonic anhydrase (CA) isozymes I and II by some phenyl and pyridyl substituted sulfanilamide Schif's bases we have found that activity can better be explained by considering the directions of the nodes in π-like near frontier orbitals in the molecules. The near-frontier orbitals involved are those that are analogous to the degenerate pairs of HOMO and LUMO orbitals of benzene. This effect seems common in compounds which contain variously substituted benzene rings and is probably critical to understanding the activity of any aromatic molecule which is bound to its receptor by π–π charge transfer interactions.     

Stable multiwavelength and passively mode-locked Yb-doped fiber laser based on nonlinear polarization rotation

Based on the nonlinear polarization rotation (NPR) technique and a fiber Mach–Zehnder interferometer (MZI), a fiber laser which can work in two different modes has been demonstrated. In one mode, it works as a continuous wave (CW) multiwavelength laser, and stable dual-, triple- and tetra-wavelength lasing with the wavelength spacing of 1.1 nm are obtained. In the other mode, it works as a passively mode-locked fiber laser, and the generated pulses have a repetition rate of 10.6 MHz, an FWHM width of 800 ps and the largest energy of 1 nJ. The multi-functional property makes this fiber laser a very convenient, cost effective and multi-purpose laser source.     

Everything you wanted to know about phase and reference frequency in one- and two-dimensional NMR spectroscopy

The fundamental concept of phase discussed in this tutorial aimed at providing students with an explanation of the delays and processing parameters they may find in nuclear magnetic resonance (NMR) pulse programs. We consider the phase of radio-frequency pulses, receiver, and magnetization and how all these parameters are related to phases and offsets of signals in spectra. The impact of the off-resonance effect on the phase of the magnetization is discussed before presenting an overview of how adjustment of the time reference of the free induction decay avoids first-order correction of the phase of spectra. The main objective of this tutorial is to show how the relative phase of a pulse and the receiver can be used to change the reference frequency along direct and indirect dimensions of NMR experiments. Unusual of phase incrementation with non-90° angles will be illustrated on one- and two-dimensional NMR spectra.     

Theoretical demonstration for signal gain in multiple four-wave mixing processes based on cubic susceptibility medium

An insight into the signal gain in multiple four-wave mixing (MFWM) processes based on a cubic susceptibility medium is theoretically proposed and demonstrated. A dual-pumped fiber optical parametric amplification (FOPA) model is developed with the exact expressions for the signal gain and its 3-dB bandwidth successfully yielded. With these analytical expressions, we show that when pump-1 and pump-2 wavelengths tuned at 1549 and 1551.02nm, the 3-dB bandwidth of the signal gain can be achieved at about 2253.4nm theoretically by properly setting the pumped powers. Numerical simulations show that there is a small pinnacle emerging in the signal gain spectrum owing to the degenerate OPA process occurring. The proposed OPA model can find potential applications in all-optical wavelength conversion, optical amplifier, and all-optical sampling.     

光纤参量放大技术及应用

光纤参量放大基于在技术上的优势,越来越引起研究人员的重视.文章介绍了光纤参量放大器的结构及近期的研究情况,概述了其在分立集总放大、波长透明转换、慢光的产生,归零码生成及光时分复用(OTDM)等方面的应用.     

All-optical SBS reduction in fiber optic parametric amplifiers

We experimentally demonstrate an original way based on cross-phase modulation process to suppress stimulated Brillouin scattering in a fiber optical parametric amplifier (FOPA). The setup is potentially less expensive than conventional electrical modulation schemes, and good performances are reported in terms of amplification quality and high gain value.     

采用全矢量有限元法设计光子晶体光纤

阐述了基于光子晶体光纤(PCF)的光纤参量放大器(FOPA)的工作原理,对FOPA所需的PCF特性进行了讨论和设计.采用带混合节点/棱边元三角形单元的全矢量有限元法(FEM),计算了PCF中非线性系数、色散斜率和色散零点与空气孔半径、孔间距和空气填充比等结构参数间的关系.计算结果表明:在确保PCF光纤高非线性的前提下,通过灵活设计PCF的结构参数就可以实现色散控制,得到PCF的超宽波长范围内可调的零色散波长、近零超平坦色散和极低的色散斜率,从而为FDPA获得高增益、宽带宽等性能创造必要前提.     

6-channel photonic generation of ultra-wideband signals using multiple nonlinear characteristics in a parallel FOPA structure

We propose an approach to generating 6-channel polarity-inverted ultra-wideband (UWB) doublets by utilizing the parallel fiber-optical parametric amplifier (FOPA) configuration.The pulse-splitting effe...     

光纤参量放大器增益特性的理论与仿真分析

为了优化光纤参量放大器的增益特性,利用理论分析,对FOPA在不同光纤长度、不同泵浦光功率及不同光纤非线性系数下的增益与带宽特性进行了比较与分析。结果表明:使用较长的高非线性光纤、较大的泵浦光、或较大的非线性系数,均可提高FOPA的增益,增益带宽也可随着泵浦光功率和非线性系数的增大而增大。此外,利用仿真模拟对理论分析结果进行了验证。虽然,仿真结果与理论分析结果间略有偏差,但仿真结果依然较好的验证了理论结果的正确性与可行性。