QM/QM study of the coverage effects on the adsorption of amino-cyclopentene at the Si(100) surface

In this work, we have tested 30 different adsorption situations in several coverage scenarios for the 1-amino-3-cyclopentene (ACP) molecule on the Si(100) surface. We have used a five-spot testing zone inserted in the high-level part of a quantum-mechanical/quantum-mechanical study performed in a big cluster. By defining several different scenarios, each one with a typical adsorption energy, we were able to understand in detail the process of surface functionalization. We are able to justify why the functionalization of this silicon surface achieves only a coverage of approximately 0.5 ML (half monolayer) and why the completely covered surface should be thermodynamically impossible to obtain.     

社交网络用户浏览轨迹信息隐私保护方法仿真

随着网络应用的广泛普及,QQ、微信、YY语音、陌陌等社交软件走进千家万户,但社交网络用户浏览轨迹信息隐私保护问题也随之而来。由于社交网络平台安全机制存在漏洞,抵御网络攻击性能不强,使社交网络用户信息纷纷泄露。针对问题根源,提出ACP用户隐私信息防护系统,建立社交网络用户真空登陆模块(VM)、通讯信息密码文模块(RDT)及信息储存保护墙模块(LDM)一体化ACP用户隐私信息防护系统,从根源保护社交网络用户浏览轨迹信息的隐私安全。通过数据模拟仿真实验证明提出的ACP用户隐私信息防护系统,对社交网络用户浏览轨迹信息隐私保护具有可用性与有效性。     

Ultrasonic enhancing amorphization during synthesis of calcium phosphate

Amorphous calcium phosphate (ACP) has great application potential in biomaterials field due to its non-cytotoxicity, high bioactivity, good cytocompatibility, and so on. The results of this research demonstrated that ultrasonic obviously enhanced amorphization during synthesis of calcium phosphate. The ACP phase was relatively ideal when the solvent of Ca(NO₃)₂·4H₂O was ethanol and the solvent of (NH₄)₂HPO₄ was a mixture of water and ethanol, under ultrasonic. In-situ crystallization of ACP could be observed by HRTEM. The mechanism on the effects of ultrasonic on amorphization of the synthesized calcium phosphate was discussed. It was suggested that ultrasonic synthesis might be a facile method to prepare pure and safe ACP related biomaterials.     

基于Quartet测试系统的高速DAC芯片测试

介绍了通用DAC芯片的主要测量参数及其测试方法。并以12-bit高速DAC芯片ISL5861为例,利用Credence公司的数模混合信号测试系统Quartet实现对高速数模转换芯片进行测试。     

Ⅱ型脂肪酸生物合成途径机制和药物发现研究进展

Ⅱ型脂肪酸合成途径（FAS-Ⅱ）是细菌和植物体内进行饱和/不饱和脂肪酸合成的唯一必需途径.FAS-Ⅱ由一系列单一基因编码的可溶性酶组成，通过依次循环式的识别和催化由酰基载体蛋白（ACP）共价携带的脂肪酸碳链底物来实现特定长度饱和/不饱和脂肪酸碳链的延长和合成.由于FAS-Ⅱ在细菌生理活动中具有不可或缺的作用，同时与哺乳动物脂肪酸合成途径FAS-I存在显著差异，FAS-Ⅱ的酶系长久以来都被公认为是重要的抗菌药物靶标群.因此，阐明该途径酶系的催化调控机制，发展靶向FAS-Ⅱ酶系的抗菌药物是该领域的研究重点.综述FAS-Ⅱ近年的分子机制研究和药物发现进展有助于进一步了解FAS-Ⅱ的生物学功能并推动全新抗菌药物的发现.     

基于ANSYS ACP的复合材料螺旋桨流固耦合计算方法

针对复合材料螺旋桨的流固耦合水弹性行为,为形成双向耦合的集成平台,对复合材料螺旋桨进行了流固耦合计算方法的研究。在ANSYS Workbench平台中,采用ACP模块对复合材料螺旋桨的建模进行了分析,介绍了复合材料螺旋桨的建模流程、流体计算模型和固体计算模型。通过静态加载试验对复合材料螺旋桨建模方法的可靠性进行了验证,计算值与试验值的偏差在5.1%以内,且反映出材料的各向异性。通过空泡水洞模型试验对复合材料螺旋桨流固耦合敞水性能计算方法的精确度进行了验证,在转速为12.7r/s和25r/s两个工况下计算的推力和扭矩与试验值吻合较好。验证了基于ANSYS ACP的复合材料螺旋桨稳态流固耦合计算方法合理可行,为复合材料螺旋桨的流固耦合振动特性分析提供了参考。     

一二次雷达合装系统中方位信号处理电路设计

在一二次雷达合装系统中,方位信号处理电路经常由于雷击而损坏,造成合装的两部雷达均无法正常工作,影响民航航班的飞行安全。文中分析了一个方位信号处理电路的设计方案,经测试,其可取代雷达原有的方位处理电路,保证雷达的持续工作。     

草鱼ANAE阳性细胞及免疫组织和巨嗜细胞ACP活性分析

草鱼在接受嗜水产气单胞菌免疫 10d, 20d 和 30d以后,其血液、前肾、脾脏和胸腺中 AN AE阳性细胞百分率上升,同时发现血液、前肾和脾脏的巨嗜细胞或组织匀浆的 AC P活性也上升,表明鱼体受抗原刺激后处于免疫应答状态,免疫力相对提高. 作者认为可以把鱼类的免疫相关器官或血液中ANAE阳性细胞的相对比率和酸性磷酸酶的相对活性作为鱼体免疫机能的检测指标之一.     

QSAR,docking studies of 1,3-thiazinan-3-yl isonicotinamide derivatives for antitubercular activity

The enzyme – enoyl acyl carrier protein reductase (enoyl ACP reductase) is a validated target for antitubercular activity. Inhibition of this enzyme interferes with mycolic acid synthesis which is crucial for Mycobacterium tuberculosis cell growth. In the present work 2D and 3D quantitative structure activity relationship (QSAR) studies were carried out on a series of thiazinan–Isoniazid pharmacophore to design newer analogues. For 2D QSAR, the best statistical model was generated using SA-MLR method (r² = 0.958, q² = 0.922) while 3D QSAR model was derived using the SA KNN method (q² = 0.8498). These studies could guide the topological, electrostatic, steric, hydrophobic substitutions around the nucleus based on which the NCEs were designed. Furthermore, molecular docking was performed to gauze the binding affinity of the designed analogues for enoyl ACP reductase enzyme. Amongst all the designed analogues the binding energies of SKS 01 and SKS 05 were found to be −5.267 kcal/mol and −5.237 kcal/mol respectively which was comparable with the binding energy of the standard Isoniazid (−6.254 kcal/mol).     

银鲳卵巢发育与磷酸酶ACP及AKP活性的关系

为了探究人工养殖银鲳(Pampus argenteus)卵巢发育成熟过程中相关磷酸酶的变化规律, 采用组织切片的方法系统描述了各期卵巢的形态特征及其组织学结构变化, 并分析了其卵巢、肝脏和肌肉中酸性磷酸酶(ACP)和碱性磷酸酶(AKP)的活性. 结果表明 (1)银鲳卵巢在Ⅱ期末出现嗜碱性的卵黄核, 第3时相卵母细胞出现卵黄颗粒沉积现象; 至第4时相卵黄颗粒明显增多, 脂滴出现, 直至充满整个卵母细胞, 核开始偏位; 第5时相卵子内卵黄颗粒已融合成块状. (2)随性腺发育, 卵巢、肝脏和肌肉中ACP和AKP活性均表现出显著变化(P<0.05); ACP和AKP酶活性表现为 卵巢>肌肉>肝脏, 在卵巢中ACP活性变化幅度为18.742~73.381U; AKP为41.272~ 63.370U. (3)肌肉中的ACP和AKP以及肝脏中的AKP活性从Ⅰ期至Ⅵ期均呈现下降趋势, 而卵巢中的ACP与AKP酶活性则先升后降. 研究认为3种组织中ACP和AKP活性变化与银鲳卵巢发育中卵黄积累显著相关(P<0.05).