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891.
892.
Chiral analytical method development and application to pre‐clinical pharmacokinetics of pinocembrin
Casey L. Sayre Jody K. Takemoto Stephanie E. Martinez Neal M. Davies 《Biomedical chromatography : BMC》2013,27(6):681-684
An analytical method enabling the detection and quantification of the individual enantiomers of racemic (±) pinocembrin is required to fully characterize its pharmacokinetic disposition. Direct resolution of the enantiomers of pinocembrin was achieved using a novel and simple reversed‐phase high‐performance liquid chromatography method with electrospray ionization and detection by mass spectrometry in rat serum. A Chiralcel® AD‐RH column was employed to perform baseline separation with electrospray positive‐mode ionization with selected ion monitoring detection. The standard curves were linear from 0.5 to 100 µg/mL for each enantiomer. The limit of quantification was 0.5 µg/mL. The assay was applied successfully to stereoselective serum disposition of pinocembrin enantiomers in rats. Pinocembrin enantiomers were detected in serum. Both enantiomers had a serum half‐life of ~15 min in rats. Similar values of volume of distribution between the enantiomers were also observed: 1.76 L/kg for S‐pinocembrin and 1.79 L/kg for R‐pinocembrin. Total clearance was 5.527 L//h/kg for S‐pinocembrin and 5.535 L/h/kg for R‐pinocembrin, and the area under the curve was 1.821 µg h/mL for S‐pinocembrin and 1.876 µg h/mL for R‐pinocembrin. The large volume of distribution coupled with the short serum half‐life suggests extensive distribution of pinocembrin into the tissues. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
893.
Koichiro Shirota Ichirou Yamaguchi Kiyoshi Kanie Tomiki Ikeda Tamejiro Hiyama Ichiro Kobayashi 《Liquid crystals》2013,40(5):555-558
The optical properties of two kinds of photochromic antiferroelectric liquid crystal (AFLC) containing an azo group have been examined. Depending on the substituting group at the chiral centre, these AFLCs showed different photoinduced phase transitions by Ar+ laser light irradiation. This phase transition has led to a new form of optical switching controlled by a bias voltage. In addition, it was found that these AFLCs caused an azimuthal photoalignment effect regulated by linearly polarized Ar+ laser light irradiation. These phenomena were applied to image storage. 相似文献
894.
Michał Terlecki Dr. Szymon Sobczak Dr. Michał K. Leszczyński Prof. Andrzej Katrusiak Prof. Janusz Lewiński 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(55):13757-13764
Understanding the factors governing the formation of supramolecular structures and phase transitions between various forms of molecular crystals is pivotal for developing dynamic, stimuli-responsive materials and polymorph-controlled syntheses. Here, we investigate the pressure-induced dynamic of both the intrinsic molecular structure and the supramolecular network of a predesigned polyhedral oxo-centered zinc cluster incorporating monoanionic N,N’-diphenylformamidinate and featuring N-bonded phenyl groups in close proximity to the primary coordination sphere. We demonstrate that the model oxo cluster is prone to undergoing pressure-induced conformational transformations of the secondary coordination sphere and simultaneous stepwise (initially every second polyhedral molecule undergoes the conformational transformations) and reversible transitions from an ambient phase α to high-pressure phases β and γ, as single-crystal-to-single-crystal events. The observed phase transitions illustrate the key role of an interplay between the low-energy conformation perturbations and cooperative intra- and intermolecular noncovalent interactions. 相似文献
895.
896.
ABSTRACTWe have studied the properties of biaxial particles interacting via an anisotropic pair potential, involving second-rank quadrupolar and third-rank octupolar coupling terms, using Monte Carlo simulation. The particles occupy the sites of a 2D square lattice and the interactions are restricted to nearest neighbours. The system exhibits spontaneous chiral symmetry breaking from an isotropic phase to a chiral modulated nematic phase, composed of ambidextrous chiral domains. When twofold axes of quadrupolar and octupolar tensors coincide this modulated phase appears to be the ambidextrous cholesteric phase with pitch comparable to a few lattice spacings. The associated phase transition is first order. 相似文献
897.
Maja Trček George Cordoyiannis Brigita Rožič Vassilios Tzitzios George Nounesis Samo Kralj 《Liquid crystals》2017,44(10):1575-1581
We report on the stabilisation of the liquid-crystalline, twist-grain boundary A (TGBA) phase in mixtures of a chiral liquid crystal and surface-functionalised spherical Au nanoparticles (NPs) of 10 nm diameter. The results, obtained by calorimetric, optical, small-angle X-ray and plasmon resonance measurements, demonstrate that a TGBA phase, which is metastable for the pure liquid crystal host, can be effectively stabilised for a 3 K range in the presence of NPs. Moreover, the role of NPs size on the TGBA stabilisation is briefly discussed. 相似文献
898.
ABSTRACTA homologous series of new chiral liquid crystal compounds, MnBEB (n = 4–10), was prepared by covalently linking a chiral (–)-menthyl with biphenyl-benzoate via a dicarboxylic spacer of varying length and parity. A combination of analysis methods, such as FT-IR, 1H NMR spectra, differential scanning calorimetry (DSC), polarised optical microscopy (POM) and X-ray diffraction was carried out to systematically investigate their phase structures and phase transition behaviours. The length and parity of the flexible spacers has a profound influence on the Tm and Tc and a modest odd-even effect is observed for the chiral liquid crystal compounds MnBEB. Only compound M4BEB developed an N* phase with selectively reflection on heating and a blue phase on cooling process. In addition, increasing the length of the flexible spacers tends to narrow the temperature range of the N* phase and widen the smectic phase, moreover, the pitch becomes longer with the spacer increases. 相似文献
899.
We prepared some taper-shaped liquid-crystalline trimers in which two phenylpyrimidine units and a 1,4-diphenyl-2,3-difluorobenzene unit are connected to 2,4-dihdroxy benzoic acid via flexible spacers. We then investigated their liquid-crystalline properties using polarised optical microscopy, differential scanning microscopy and X-ray diffraction. 6-[4–(5-Octylpyrimidin-2-yl)phenyloxy]hexyl 2-{7-{4-[4–(4-hexylphenyl)-2,3-difluorophenyl]phenyloxy}heptanoyloxy}-4-{6-[4–(5-octylpyrimidin-2-yl)phenyloxy]hexyloxy}benzoate (1) was found to exhibit a phase sequence of isotropic liquid – nematic – intercalated smectic A – intercalated anticlinic smectic C – modulated smectic C. The structure–property relation in the taper-shaped trimers reveals that the modulated phase is induced by competition between an intercalated structure stabilised by dipole–dipole interaction and a monolayer structure by packing entropy effects. Conformational change of compound 1 induced by intermolecular interactions plays an important role in the phase transition behaviour. 相似文献
900.
Xiaotian Li Baoluo Wan Tong Yu Linxi Wang Lianqi Hao Maowen Guo 《Biomedical chromatography : BMC》2013,27(12):1595-1602
A reversed‐phase ion pair chromatography method with liquid–liquid extraction analytical method was developed and validated for the determination of antazoline hydrochloride in plasma and excreta of rat. The aim of our study was to characterize the preclinical pharmacokinetics and excretion profiles of antazoline hydrochloride in rats after intravenous injection at the dose of 10 mg/kg. Plasma and excreta samples were extracted with ethyl acetate, and phenacetin was used as the internal standard. The result showed that the method is suitable for the quantification of antazoline hydrochloride in plasma and excreta samples. Analysis of accuracy (90.89–112.33%), imprecision (<7.1%) and recovery (>82.5%) showed adequate values. After a single intravenous administration at 10 mg/kg to rats, plasma concentration profile showed a relative fast elimination proceeding with a terminal elimination half‐life of 3.53 h. Approximately 61.8 and 14.2% of the administered dose were recovered in urine and bile after 72 and 24 h post‐dosing respectively; 5.9% of the administered dose was recovered in feces after 72 h post‐dosing. The above results show that the major elimination route is urinary excretion. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献