两种光亮度定义几何图示的比较分析

目前通行的光学教材中关于光亮度定义的文字叙述和数学表达式基本相同,但是却有两种不同的几何图示．本文对光亮度定义的两种几何图示作了比较分析,指出其中一种几何图示不能既准确又形象地描述光亮度的定义．     

单点子域积分与差分

通过稳定性分析、显式与隐式积分,表明了单点子域积分相对于差分法的优越性．     

绕旋转圆柱流动涡尾流结构和临界状态特性

采用作者提出的基于区域分解、有限差分法与涡法杂交的数值方法,结合高阶隐式差分格式,和以修正的不完全ＬＵ分解为预处理器的共轭梯度法作求解器．系统地研究了雷诺数Ｒｅ＝１０００,旋转速度比ａ∈（０．５,３．２５）范围内,绕旋转圆柱从突然起动到充分发展,长时间内尾流旋涡结构和阻力、升力系数的变化规律．计算所得流动图案与实验流场显示符合很好．数值试验证实了临界状态的存在,并首次给出了临界状态时的旋涡结构特性,指出最佳升阻比也在该状态附近得到     

旋涡、湍流与自由表面的相互作用

旋涡及自由表面湍流与自由表面的非定常、非线性相互作用是当前流体力学中一个十分活跃的前沿领域的研究课题,它具有深刻的理论意义和重要的实用背景．旋涡、湍流与自由表面的相互作用是一个非常复杂的非线性、非定常过程,涉及到涡－涡、波－涡相互作用,旋涡在自由表面处的断裂、重联、合并及自由表面湍流中的准拟序结构的形成、发展等复杂动力学过程．关于这一领域的研究已经取得了一些重要成果．对旋涡与自由表面的相互作用的基本过程有了较为清楚的认识;但对湍流与自由表面的相互作用中的许多基本物理过程还知之甚少．本文综述此领域的实验、理论和数值模拟研究的最新进展和主要结果,讨论若干有待解决的问题,并指出进一步的研究方向     

旋涡与行进表面水波相互作用的实验研究

采用振动板式造波器在二维水槽中生成近似单色的行进表面水波,采用夹板式涡发生器生成稳定上浮的涡对,在Ｆｒｏｕｄｅ数约为０．５的条件下,得到了水下涡对与不同波长和振幅的行进表面水波相互作用时的干扰图象,以实验方法验证了理论分析和数值计算的结果,并为进一步研究旋涡与行进表面水波的相互作用提供了一种实验研究方法     

Photolysis of 2-dialkylamino-3-amino(or alkylamino)-1,4-naphthoquinones

Using¹H and¹³C NMR spectroscopy, naphthodihydroimidazolediols were identified as the primary products of photolysis of 2-dialkylamino-3-amino(alkylamino)-1,4-naphthoquinones. Their further non-photochemical (thermal) transformations depend on their structure and on the photolysis conditions.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 358–362, February, 1993.     

In vitro antiproliferative activity of glabridin derivatives and their in silico target identification

Abstract

Novel Mannich base derivatives of glabridin were synthesized and their antiproliferative activity were performed along with our previously reported glabridin-chalcone hybrids molecules (GCHMs) against various human cell lines MDA-MB-231 (breast adenocarcinoma), HEK-293 (embryonic kidney cell line), K562 (leukemia), MCF-7 (breast adenocarcinoma), HeLa (cervix adenocarcinoma), HepG2 (hepatocellular carcinoma) and WRL-68 (hepatic carcinoma). The result showed that the glabridin significantly reduced cell proliferation with IC₅₀ ranges from 3.67 to 58.30?µM against all the tested cell lines. The remarkable reduction in antiproliferative activity 2’,4’-dimethoxyglabridin and GCHMs compounds with phenolic OH groups protected by methoxy (OCH₃) groups suggested that the free OH groups are essential factor for the antiproliferative activity of glabridin and its derivatives. The Mannich base derivatives of glabridin showed moderate activity IC₅₀ (2.20–>95.78?µM). Furthermore, in silico target identification analysis revealed that AKT1, DECR1 and NOS1 are the potential targets for glabridin and their derivatives.     

Structure-activity relationship of Ca2+ channel blockers: A study using conformational analysis and chemometric methods

Summary A structure-activity relationship study has been done on 8 compounds with the activity known as Ca²⁺ channel blockers. Conformational analysis was carried out using a molecular mechanics method. The 3D-QSAR approach was used and the most polar functional groups present in all the molecules were considered. Eight interatomic distances are necessary to define the relative spatial disposition of these relevant molecular fragments. The structure-activity relationship between interatomic distances and biological activity was performed using statistic and chemometric methods. In particular, with Principal Component Analysis, it was possible to reduce the number of interatomic distances: only six of the eight distances are sufficient to describe the system in a useful way. A classification method was iteratively used to select the most probable conformations linked to the biological activity and to build a model able to classify conformations according to their biological behaviour. Cluster analysis on the active selected conformations subsequently allowed the identification of two different geometrical patterns for the active compounds. Finally the validity of the model was verified by correctly predicting the activity of other molecules not used in the construction of the model but possessing known activity.     

Individual determination of ortho and non-ortho substituted polychlorobiphenyls (PCBs) in sediments by high performance liquid chromatographic pre-separation and gas chromatography/ECD detection

Summary An analytical procedure for the individual determination of ortho and non-ortho PCB congeners in sediments, using high performance liquid chromatography (HPLC) preseparation and gas chromatography/ECD detection, is described. Gas chromatography/FTIR spectrometry (GC/FTIR) and gas chromatography/mass spectrometry (GC/MS) were employed for individual congener identification and determination. Sample extraction, clean-up of extract and selective elution procedures were optimized by using reference certified marine sediment samples. Recovery and precision were typically 83% and 16% respectively at 2 ng/g of total PCB content. The proposed procedure, tested by analyzing real sediment samples, showed a reproducibility better than 20% at 13 ng/g PCB level.     

食用香料甲基2-甲基-3-呋喃基二硫醚的分离提纯及结构鉴定

 用气相色谱法分离提纯食用香料甲基 2 甲基 3 呋喃基二硫醚 ,纯度 (质量分数 )达到 99.5%。分离柱为4%FFAP +1 %H3PO4ChromosorbW /AW DMCS(80目～ 1 0 0目 )不锈钢柱。用红外光谱、气相色谱 /质谱和核磁共振谱进行了结构鉴定。