温度变化导致航天相机光学系统像面位移的研究

温度变化导致的像面位移会影响航天相机光学系统的成像质量。根据高斯光学理论,推导出了温度变化时的相机光学系统的像面位移公式,确定了温度敏感性最低的主、次反射镜的材料及与之相匹配的镜筒材料。最后计算和比较了在不同温度变化时的光学系统的传递函数。     

基于CMOS图像传感器的成像系统设计

以OV 5 116CMOS图像传感器为例 ,讨论了基于CMOS图像传感器的成像系统的电路设计方法及系统设计中应注意的问题 ;并通过对CMOS图像传感器外围电路的优化设计实现了成像系统的微型化和轻量化。     

Low distortion recording of transient low- light-level phenomena

Two types of low-light-level image sensors have been investigated for use in low distortion recording: an SIT-vidicon (Silicon-Intensifier Target), and a sensor consisting of a newvicon and two stage proxifier. The results are compared and discussed. In addition, a triggerable video frame store is described.     

In Vitro–In Vivo Correlation of Tianeptine Sodium Sustained-Release Dual-Layer Tablets

Tianeptine tablets are currently marketed to be designed for immediate-release tablets. The tianeptine has a short half-life, making it difficult to design for sustained-release tablets and achieve bioequivalence with the tianeptine immediate-release tablet (Stablon^®). We established the in vitro–in vivo correlation (IVIVC) of three formulations of tianeptine sustained-release tablets according to their granule size. To evaluate sustained drug release, in vitro tests were performed in pH 1.2 media for 24 h. In vivo pharmacokinetic analysis was performed following oral administration of reference drug and test drug to beagle dogs. The dissolution profile revealed delayed release as the size of the granules increased. The dissolution results were confirmed in pharmacokinetic analysis, showing that the half-life was delayed as granule size increased. The final formulation and reference drug showed an equivalent area under the curve (AUC). Through this, IVIVC was established according to the size of the tianeptine sodium granules, which is the purpose of this study, and was used to predict in vivo pharmacokinetics from the formulation composition. This approach may be useful for determining optimal formulation compositions to achieve the desired pharmacokinetics when developing new formulations.     

基于形态学水线区域的深度图像分割

深度图像分割是基于特征关系图匹配的曲面物体识别中的关键技术之一,针对已有深度图像分割方法存在的问题,提出了一种基于二值形态学的水线区域增长算法对深度图像进行分割。首先用结构元素迭代腐蚀深度图像形成距离图像;然后根据距离图像计算极限腐蚀的集合,提取出目标的种子点;最后用条件粗化从种子点开始生长回到原尺寸但不使各区域相连,完成深度图像的分割。实验证明,算法的分割结果与人的主观视觉感知具有良好的一致性。     

强激光装置中玻璃疵病在线检测的光学系统设计

介绍了一种用于玻璃疵病在线检测的近摄工作距成像光学系统,其光组结构形式采用了光阑后置的准远心结构形式,主要光学参量为f′=14 mm;在物像距为250 mm约束条件下,物方视场达到90 mm（对角线）;F/number=3.56;光谱适应范围为400~800 nm,对应的空间分辨率为100 lp/mm时,调制传递函数大于0.29.     

航天器对接相对位置姿态自主测量方法研究

航天器间相对位置姿态的准确测量是实现自主自动对接的先决条件。将三圆标志靶安装在目标航天器上;追踪航天器用数码相机对靶拍照。设计了亚像素处理方法实时处理数字照片,可精确测定圆心像点位置和特征直径的像长;用其作为基本特征参数,基于透视投影原理,建立了求圆心物空间坐标的公式,求出靶面的平面方程,可用来求两航天器间的相对位置姿态参数和实时标定相机的可变参数。计算机仿真结果表明,测距为2m时,测圆心像点位置的误差小于0.03个像素,测距误差小于1mm,测姿态角的误差小于0.01°。该方法也适用于无人直升飞机定点着陆时自主测量其相对位姿参数。     

基于二代curvelet变换的图像融合研究

曲波(Curvelet)作为一种新的多尺度分析方法比小波更加适合分析二维图像中的曲线或直线状边缘特征,而且具有更高的逼近精度和更好的稀疏表达能力.将curvelet变换引入图像融合,能够更好地提取原始图像的特征,为融合图像提供更多的信息.第二代curvelet理论的提出也使得其理论更易理解和实现.因此,提出了一种基于第二代curvelet变换的图像融合方法,首先将图像进行curvelet变换,然后在相应尺度上利用融合规则将curvelet系数融合,最后进行重构得到融合结果.对多聚焦图像进行了实验,采用均方误差、偏差指数和相关系数对融合结果进行了客观评价,并与基于小波变换的融合进行了比较,实验结果表明该方法除分解2层时与小波性能相当,取其他分解层数时均获得更好的融合效果.     

Exploring the Parallel G-Quadruplex Nucleic Acid World: A Spectroscopic and Computational Investigation on the Binding of the c-myc Oncogene NHE III1 Region by the Phytochemical Polydatin

Trans-polydatin (tPD), the 3-β-D-glucoside of the well-known nutraceutical trans-resveratrol, is a natural polyphenol with documented anti-cancer, anti-inflammatory, cardioprotective, and immunoregulatory effects. Considering the anticancer activity of tPD, in this work, we aimed to explore the binding properties of this natural compound with the G-quadruplex (G4) structure formed by the Pu22 [d(TGAGGGTGGGTAGGGTGGGTAA)] DNA sequence by exploiting CD spectroscopy and molecular docking simulations. Pu22 is a mutated and shorter analog of the G4-forming sequence known as Pu27 located in the promoter of the c-myc oncogene, whose overexpression triggers the metabolic changes responsible for cancer cells transformation. The binding of tPD with the parallel Pu22 G4 was confirmed by CD spectroscopy, which showed significant changes in the CD spectrum of the DNA and a slight thermal stabilization of the G4 structure. To gain a deeper insight into the structural features of the tPD-Pu22 complex, we performed an in silico molecular docking study, which indicated that the interaction of tPD with Pu22 G4 may involve partial end-stacking to the terminal G-quartet and H-bonding interactions between the sugar moiety of the ligand and deoxynucleotides not included in the G-tetrads. Finally, we compared the experimental CD profiles of Pu22 G4 with the corresponding theoretical output obtained using DichroCalc, a web-based server normally used for the prediction of proteins’ CD spectra starting from their “.pdb” file. The results indicated a good agreement between the predicted and the experimental CD spectra in terms of the spectral bands’ profile even if with a slight bathochromic shift in the positive band, suggesting the utility of this predictive tool for G4 DNA CD investigations.     

“东方经济”与中国乡村工业化的社会学机制—重访史国衡的个旧矿城研究

本文对“魁阁”社会学家史国衡1940年代在美访学期间的一部未刊稿《个旧矿城》进行了梳理与讨论。史国衡的个旧研究呈现了一个将产业、民情与治理相结合的综合进路,通过对个旧锡业兴衰的个案分析,揭示了传统“东方经济”模式的独特特征以及决定中国乡村工业化成败的社会学机制,同时也以个旧经验对现代化理论、人际关系学派等当时美国社会科学主流范式提出了反思。《个旧矿城》与另一部更为人所熟知的著作《昆厂劳工》共同构成了史国衡关于中国工业化研究的姊妹篇,“工业化的社会基础”是其中一以贯之的核心线索。对史国衡个旧矿城研究的“再发现”,有助于我们重新认识中国早期社会学的工业研究传统,同时也提示我们,当下的乡村工业化乃至乡村振兴仍然需要重视产业的社会基础,处理好经济转型与社会重组之间的辩证关系。