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21.
Paul W. Chun 《International journal of quantum chemistry》2001,85(6):697-712
This communication will demonstrate the existence of a thermodynamic molecular switch in the pairwise, sequence‐specific hydrophobic interaction of Ile–Ile, Leu–Ile, Val–Leu, or Ala–Leu over the temperature range of 273–333 K reported by Nemethy and Scheraga in 1962. Based on Chun's development of the Planck–Benzinger methodology, the change in inherent chemical bond energy at 0 K, ΔH°(T0), is 3.0 kcal mol?1 for Ile–Ile, 2.4 for Leu–Ile, 1.8 for Val–Leu, and 1.2 kcal mol?1 for Ala–Leu. The value of ΔH°(T0) decreases as the length of the hydrophobic side chain decreases. It is clear that the strength and stability of the hydrophobic interaction is determined by the packing density of the side chains, with Ala–Leu being the most stable. At 〈Tm〉, the thermal agitation energy, $\int^{T}_{0}\Delta Cp^{\circ}(T)\,dT$, is about five times greater than ΔH°(T0) in each case. Additionally, the thermal agitation energy for the same series, evaluated at 〈Tm〉, decreases in the same order, that is, as the length of the side chain decreases. This pairwise, sequence‐specific hydrophobic interaction is highly similar in its thermodynamic behavior to that of other biological systems, except that the negative Gibbs free energy change minimum at 〈Ts〉 occurs at a considerably higher temperature, 355 K compared to about 300 K. The melting temperature, 〈Tm〉, is also high, 470 K compared to 343 K in a biological system. The implication is that the negative Gibbs free energy minimum at a well‐defined 〈Ts〉 has it origin in the hydrophobic interactions, which are highly dependent on details of molecular structure. In addition to the four specific dipeptide interactions described, we have shown in our unpublished work the existence of a thermodynamic molecular switch in the interactions of 32 dipeptides wherein a change of sign in ΔCp°(T)reaction leads to a true negative minimum in the Gibbs free energy of reaction, and hence, a maximum in the related Keq. Indeed, all interacting biological systems that we have thus far examined using the Planck–Benzinger approach point to the universality of thermodynamic molecular switches. © 2001 John Wiley & Sons, Inc. Int J Quantum Chem, 2001 相似文献
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研究发现, [Ru(phen)2dppz]2+表现出非常强的自聚合倾向, 并显著影响DNA的键合性质, 有关方面的研究应引起科研工作者的足够重视. 相似文献
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设计了开关控制实验,专门对常见的开关特点及使用进行探讨,根据开关特点搭建相应的控制电路,用近似于工程项目的形式锻炼学生对开关的灵活应用,激发了学生实验的兴趣和积极性. 相似文献
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New designed DNA light switch Ruthenium complexes as DNA photocleavers and Topoisomerase I inhibitors
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Xue‐Wen Liu Yang Xiao Wei‐Gen Peng Li‐Jin Zhao You‐Ming Shen Song‐Bai Zhang Ji‐Lin Lu 《应用有机金属化学》2018,32(4)
Two ruthenium complexes containing a new ligand phipz (phipz = 2‐(1,10‐phenanthroline)‐1H‐imidazo[4,5‐b]phenazine) were designed and synthesized. These complexes were found to inhibit the DNA supercoiled relaxation mediated by topoisomerase I (topo I), cleave DNA under irradiation and bind to calf thymus DNA through intercalative mode. Furthermore, complex 2 shows higher photocleavage activity, topo I inhibition activity and DNA affinity than complex 1 . Additionally, introduction of phenazine unit may be the reason that two complexes exhibit DNA ‘light switch’ behavior. The present work shows that two complexes might be potential as new DNA ‘light switches’, DNA photocleavers and topo I inhibitors. 相似文献
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气体开关是脉冲功率系统的关键部件,开关的火花通道阻抗直接影响负载电压的陡度及其能量传输效率。提出一种光谱学诊断方法,通过对火花通道成像光谱的时空分辨测量,获得通道半径及电导率,从而计算时变的火花电阻。光谱测量结果表明,氮气间隙火花放电通道电子温度为2~3eV,通道电导率先增大后减小,最大值约16 000S,随着放电发展,火花通道电阻从绝缘状态快速跌落并趋于稳定值,时变趋势与电学计算结果基本吻合。3~100kPa范围内,随着气压增大,放电通道半径减小,火花通道电阻增大。 相似文献