天然产物Kinsenoside的全合成研究

以5-(R)-[(1R，2S，5R)-孟氧基]-2(5H)-呋喃酮为关键手性合成子，完成了具有抗高血脂活性的天然产物kinsenoside的全合成研究。     

First synthesis of α-aminophosphonates from natural porphyrin derivatives by the Kabachnik—Fields reaction

A preparative procedure is proposed for the synthesis of α-aminophosphonates of natural porphyrins by the microwave-assisted Kabachnik—Fields reaction.__________Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 256–259, January, 2005.     

Ion interaction approach to calculations of volumetric properties of aqueous multiple-solute electrolyte solutions

The ion interaction approach developed by Pitzer was used for the prediction of volumetric properties of mixed electrolyte solutions at 25°C based on parameters calculated from experimental data for single-solute electrolyte solutions. Such an approach was shown to be especially effective for application to the calculation of volumetric properties of natural hypersaline brines and of industrial electrolyte solutions of large complexity. The use of the latest recommended sets of volumetric ion interaction parameters for single electrolyte solutions and symmetrical mixing parameters for Na–K–Cl ion combinations considerably improved the precision of the density calculations of highly concentrated mixed electrolyte solutions and of various natural waters.     

Cs2CO3 Promoted coupling reactions for the preparation of skipped diynes

An improved methodology for the preparation of copper(I) alkynides has been developed using cesium carbonate as base. In the presence of cesium carbonate and CuI various 1-alkynes were converted smoothly to the corresponding copper alkynides which in situ reacted with propargylic halides in order to synthesize skipped diynes.     

Synthesis of jasplakinolide analogues containing a novel omega-amino acid

The synthesis of the omega-amino acid 4 is described utilizing a two-dimensional synthesis strategy combined with an enzymatic differentiation of homotopic ester groups. The amino acid 4 features two non-bonded interactions that result in conformational constraints on a cyclic construct. This amino acid was incorporated into the four macrolactams 17, 22, 31, and 37. The ring in 17 and 22 is 18-membered, whereas 31 and 37 have a 19-membered ring. The pairs with the same ring size differ in a N-methyl group. For the larger macrolactams (31 and 37) conformational analysis showed that the macrocyclic rings are somewhat more rigid than in the natural lead, the depsipeptide jasplakinolide. Nevertheless, their conformations are comparable to the natural product. There are no intramolecular hydrogen bonds, neither is the cis-rotamer populated in the N-methyl compound 37. Due to the increased flexibility of the smaller macrolactams 17 and 22 and signal overlap, a distinct solution structure could not be obtained for these compounds. The amino acid 4 should be useful for restricting the conformation of other small peptides.     

利用分子对称性简化天然有机产物合成设计的策略

本文综述了利用分子对称性简化天然有机产物合成设计的策略,讨论了具有下述四种对称性的分子的合成:一、对称中心和旋转对称轴;二、对称平面;三、潜在的对称性;四、局部的对称性。     

Total synthesis of the polyenoyltetramic acid polycephalin C

The total synthesis of the polyenoyltetramic acid polycephalin C is described. Key steps of the synthesis include a double Swern oxidation, double Takai reaction and a double Stille reaction. In addition, the absolute stereochemistry of the ring junction has been determined by synthesis of both isomers and comparison of their CD spectra with natural polycephalin C.     

A Study of the Hydration of Lime-Pozzolan Binders

DTA/TG and TG/DTG thermal studies and XRD investigations were carried out on pastes of lime-pozzolan binders to examine the relative hydration process. The binders were prepared with two natural pozzolans and hydrated lime, mixed together in different proportions. The main hydrated phases formed in the pastes are calcium silicate hydrate (CSH) and mono-carboaluminate. The growth of CSH was greater for the paste of the pozzolan richer in reactive constituents. For pastes with a higher lime/pozzolan ratio, a slowing of the formation of CSH was observed, while the formation of monocarboaluminate was more intense. The calcium hydroxide contents of the pastes obtained by thermogravimetric analysis made it possible to determine the pozzolanic activities of the two pozzolans under examination. The mortars for the various lime-pozzolan binders displayed characteristic hardening. This revised version was published online in July 2006 with corrections to the Cover Date.     

Configurational analysis of the natural product passifloricin A by quantum mechanical C NMR GIAO chemical shift calculations

Quantum chemical calculations at mPW1PW91 level, with full geometry optimization, using the 6-31g(d) basis set, and GIAO (gauge including atomic orbitals) ¹³C NMR chemical shifts using the 6-31g(d,p) basis set, are here utilized as a support to define the configurational features of the natural product passifloricin A, whose previously proposed relative configuration has been recently shown, by synthetic studies, to be incorrect. This study suggests that the relative stereostructure for passifloricin A corresponds to the δ-lactone of the (5R,7R,9S,11R)-tetrahydroxyhexacos-2-enoic acid.     

Towards the synthesis of [15]-membered stevastelins through the 2,3-epoxy analogues

A synthetic approach to the [15]-membered stevastelins, a novel class of immunosuppressant agents, is reported based on a macrolactamization route to the 2,3-epoxy derivative 6. The synthesis of this compound was achieved via a stereoselective epoxidation of the allylic alcohol 13, followed by a coupling reaction with a variety of peptide derivatives to give the epoxy peptides 7-10. After an extensive study of cyclizations with these precursors, the best result was achieved with the macrolactamization of 8 in the presence of DEPC, to obtain the epoxy cyclic depsipeptide 6 in 42% yield. From this product, an epoxy analogue of stevastelin B, compound 27, was prepared. Finally, the synthesis of the natural product was attempted through the opening of the oxirane ring contained in 6 and 26, with a variety of methyl cuprate reagents, but without success.